The Empowering Neurologist Podcast

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: https://drperlmutter.com/subscribe
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3X4 Genetics - Go to 3X4genetics.com/DrPerlmutter for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.
• https://drperlmutter.com/guides/sulforaphane/ - Free guide from Dr. Perlmutter that explains why Sulforaphane is one of the most powerful tools for protecting your brain, and how to get more of it from your food.
• https://www.thesproutingcompany.com/DRPERLMUTTER - At-home sprouting kit recommended by Dr. Perlmutter and Dr. Fahey, using this link will give you a discount
Dr. Perlmutter's groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health. Grab your copy today at www.braindefenders.com.
Join Dr. Perlmutter's Brain Defenders Immersion Course: https://drperlmutter.com/immersion-course/
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What if broccoli contains a compound that helps activate your brain's natural defense systems? In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with nutritional biochemist Dr. Jed Fahey, a pioneer in research on broccoli sprouts and sulforaphane, to explore how this fascinating plant compound activates NRF2, one of the body's key cellular defense pathways.
Dr. Fahey explains how glucoraphanin and myrosinase work together to produce sulforaphane, why broccoli sprouts are rich in this precursor, and how sulforaphane may support the body's natural detoxification and antioxidant systems.
They also explore the connection between NRF2 activation, glutathione, environmental exposures, inflammation, and brain health, and what research suggests about neurological health and healthy aging.
Dr. Fahey shares practical insights on growing broccoli sprouts at home, getting sulforaphane from food, and what to look for when evaluating supplements.
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00:00 – Why Sulforaphane Matters for Brain Health
02:24 – The Dark Matter of Nutrition: Understanding Phytochemicals
04:12 – Why Broccoli Sprouts Are a Powerful Source of Sulforaphane
07:44 – Sulforaphane in Cruciferous Vegetables and the Benefits of Moringa
15:58 – Sulforaphane, Environmental Toxins, and Air Pollution
23:12 – Why Plants Produce Sulforaphane: Nature’s Defense System
28:17 – Sulforaphane and Brain Health: Autism, Alzheimer’s, and Parkinson’s
40:56 – Heat Shock Proteins, Glutathione, and Neuroprotection
50:51 – The Science Behind Sulforaphane and Neurodegenerative Conditions
01:02:28 – How to Get More Sulforaphane: Broccoli Sprouts, Food, and Supplements
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Dr. Jed Fahey is a nutritional biochemist, researcher, and internationally recognized pioneer in the study of plant-based chemoprotection.
During 27 years at Johns Hopkins University School of Medicine, Dr. Fahey conducted extensive research into natural plant compounds and their effects on cellular defense systems. His work helped establish broccoli sprouts as a rich source of glucoraphanin, the precursor to sulforaphane.
As former Director of the Lewis B. and Dorothy Cullman Chemoprotection Center, Dr. Fahey helped advance scientific understanding of how plant compounds interact with the body's protective pathways.
Today, he continues to contribute to public science education and research into sulforaphane, NRF2 activation, and the potential health applications of these naturally occurring compounds.
Connect with Dr. Jed:
Website: https://www.jedfahey.com
LinkedIn: https://www.linkedin.com/in/jed-fahey-a3681861
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Connect with Dr. David Perlmutter:
Instagram: https://www.instagram.com/davidperlmutter/
Website: https://www.drperlmutter.com/
Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ
This podcast is produced by DrTalks.com
⁠⁠⁠⁠https://drtalks.com/channel-growth

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: www.drperlmutter.com/subscribe.
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00:00 – Introducing Nick Ortner and the Science Behind Tapping
01:06 – What Is EFT Tapping and How Might It Calm the Amygdala?
02:33 – From Skeptic to Advocate: Nick’s First Experience With Tapping
06:14 – Why Tapping Has Been Considered Fringe Despite Growing Research
08:26 – How Tapping May Help Reprocess Stressful Memories and Fear
11:46 – Reactive Loops: Why Anxiety and Anger Can Feel Automatic
14:20 – How Tapping Can Complement CBT and Exposure Therapy
19:15 – The Research on Tapping, Cortisol, and Stress Relief
22:52 – Tapping for Anxiety, Sleep, and Pain: Where Does It Help Most?
27:28 – Follow Along: Nick Ortner Guides a Step-by-Step Tapping Exercise
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Dr. Perlmutter's groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health. Grab your copy today at www.braindefenders.com.
Join Dr. Perlmutter's Brain Defenders Immersion Course: ⁠https://drperlmutter.com/immersion-course/⁠
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Can tapping help interrupt automatic stress responses and change the way your brain reacts to fear and anxiety?
In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with Nick Ortner, New York Times bestselling author and CEO of The Tapping Solution, to explore Emotional Freedom Techniques (EFT), or tapping. Nick explains how stress can trigger automatic reactions before conscious thought has time to catch up.
They explore the role of the amygdala, how reactive loops develop, and how tapping may help signal safety to the brain while working through stressful thoughts, memories, and physical sensations. They also discuss research into tapping and its potential effects on cortisol, anxiety, sleep, and pain.
Nick explains how tapping may complement cognitive behavioral therapy and exposure therapy, helping people work through difficult experiences while managing their stress response. Nick then guides listeners through a simple tapping exercise, offering an opportunity to experience the technique.
Understanding your stress response may be the first step toward changing how you respond to it. Discover how tapping may help you interrupt reactive patterns and approach stressful experiences with greater awareness.
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Nick Ortner is a New York Times bestselling author, wellness advocate, and CEO and co-founder of The Tapping Solution. For nearly two decades, Nick has helped bring Emotional Freedom Techniques, or tapping, into the mainstream. The practice combines elements of acupressure with modern psychology to help people manage stress, pain, anxiety, and limiting beliefs. Nick created the documentary The Tapping Solution and wrote The Tapping Solution: A Revolutionary System for Stress-Free Living. His book Rewired explores how tapping may help interrupt reactive loops and change nervous-system patterns. He is also the driving force behind The Tapping Solution App, which has logged more than 32 million guided sessions across 190 countries. Through his books, app, and work with The Tapping Solution Foundation, Nick helps make practical emotional health tools available to people around the world.
Connect with Nick:
Website: https://www.thetappingsolution.com
Instagram: https://www.instagram.com/thetappingsolution
YouTube: https://www.youtube.com/@TheTappingSolutionChannel
Facebook: https://www.facebook.com/nortner
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Connect with Dr. David Perlmutter:
Instagram: https://www.instagram.com/davidperlmutter/
Website: https://www.drperlmutter.com/
Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ
Podcast produced by DrTalks.com
⁠⁠⁠https://drtalks.com/channel-growth

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: https://www.drperlmutter.com/subscribe
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Brain Defenders – Dr. Perlmutter's groundbreaking new book is now available! Discover how to protect your brain and future health: https://www.braindefenders.com
====
Join Dr. Perlmutter's Brain Defenders Immersion Course: ⁠https://drperlmutter.com/immersion-course/⁠
====
About This Episode
You can be successful, respected, and highly productive while still feeling invisible.
In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with John R. Miles, bestselling author, behavioral change expert, and host of Passion Struck, to explore why achievement, recognition, and external success do not always create a lasting sense of self-worth.
Drawing from his childhood brain injury, military service, and executive career, John explains the concept of human mattering: the fundamental need to feel seen, valued, and significant. They discuss the “mattering gap,” the “slow fade” that can happen when people become disconnected from themselves, and why belonging and mattering are not the same.
John also introduces the MATTER framework, built around six conditions that help people feel valued and connected: meaning, autonomy, trust, time, energy, and reciprocity.
They explore how parents, leaders, physicians, and communities can help others feel that they matter, and why separating personal worth from productivity and external approval can lead to more meaningful relationships and intentional living.
You can continue pursuing success without making it the measure of your worth. Your value is not something you have to earn.
Timestamps
00:00 – John Miles’ Childhood Brain Injury and Defining Moment
06:16 – What It Means to Matter vs. Belong
07:32 – The Slow Fade: When Success Makes You Feel Invisible
14:43 – Understanding the Mattering Gap
19:34 – Why Children Need to Feel Seen and Valued
27:20 – The MATTER Framework: Six Conditions for Feeling Valued
31:13 – Why Patients Need to Be Seen Beyond Their Diagnosis
36:11 – Creating a Workplace Where Employees Feel Valued
44:31 – Why Your Worth Is Already a Completed Fact
48:32 – The Difference Between Proving Yourself and Accomplishing Goals
About John R. Miles
John R. Miles is a bestselling author, keynote speaker, behavioral change expert, and host of the award-winning, top-ranked podcast Passion Struck®. A former U.S. Navy officer and Fortune 50 C-suite executive, John combines military discipline, corporate strategy, neuroscience, and psychology to help people and organizations reduce isolation, strengthen self-worth, and live with greater intention.
He is the author of Passion Struck and The Mattering Effect. His work explores how people can separate their inherent worth from external achievement, build deeper relationships, and create a meaningful impact without losing themselves in the process.
Through his books, podcast, speaking, and global community, John leads a growing movement centered on one essential message: every person deserves to feel seen, valued, and significant.
Connect with John
Website: https://johnrmiles.com
Instagram: https://www.instagram.com/john_r_miles
LinkedIn: https://www.linkedin.com/in/johnmileshumanperformanceexpert
Facebook: https://www.facebook.com/johnrmiles.c0m
Podcast: https://passionstruck.com/passion-struck-podcast
Connect with Dr. Perlmutter
Instagram: https://www.instagram.com/davidperlmutter/
Website: https://www.drperlmutter.com/
Subscribe to our channel: https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ
This podcast is produced by DrTalks.com
⁠⁠http://drtalks.com/channel-growth

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at:⁠ www.drperlmutter.com⁠/subscribe. ✉️ 🌱
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Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at ⁠https:/www.braindefenders.com⁠.
Join Dr. Perlmutter's Brain Defenders Immersion Course: ⁠https://drperlmutter.com/immersion-course/⁠
====
Your food contains far more than protein, carbohydrates, fat, vitamins, and minerals. Researchers have identified more than 100,000 molecules in food, and most of them never appear on a nutrition label.
In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with his son, Dr. Austin Perlmutter, to explore the "dark matter" of nutrition: thousands of plant compounds called polyphenols.
They discuss how these nutrients may influence the gut microbiome, the immune system, inflammation, blood flow, metabolism, and gene expression, and what high-polyphenol diets may mean for memory and the aging brain.
Dr. Austin shares his research on Himalayan Tartary buckwheat and what an early study suggests about epigenetics, cognition, and healthy aging. He offers practical ways to find more polyphenols in everyday foods like coffee, tea, dark chocolate, berries, legumes, and olive oil, plus simple tips for identifying better options at the store.
You don't need an expensive supplement plan to begin. Adding more natural colors and bitter flavors to your plate can be a meaningful first step.
https://bttcorp.com/contact/ for inquiries about Dr. Abreu's work.
00:00 — Cold Open: Why Food Matters for Brain Health
00:55 — What Are Polyphenols, and Why Do They Matter?
02:15 — Food as a Predictor of Long-Term Brain Health
04:23 — The “Dark Matter” Hidden in Our Food
08:04 — Why Have These Nutrients Been Overlooked?
11:06 — What Polyphenols Actually Do in the Body
17:32 — How Food Can Change Gene Expression
22:08 — Polyphenols Are More Than Antioxidants
27:57 — Himalayan Tartary Buckwheat: Putting “Food as Medicine” to the Test
32:16 — The 850-Person Study on Food and Cognition
36:14 — Where Are We Getting Our Polyphenols?
39:19 — Are Polyphenols Actually Beneficial Stressors?
41:58 — Nrf2, mTOR, and the Cellular Effects of Polyphenols
44:45 — The Practical Takeaway: Eat the Rainbow
46:43 — Do the New Dietary Guidelines Get Polyphenols Right?
50:25 — The Hidden Brain-Healthy Ingredient in Coffee
50:52 — How to Spot a Polyphenol-Rich Olive Oil
51:39 — Dark Chocolate vs. Milk Chocolate
52:59 — The Best-Studied “Longevity Strategy” Is Surprisingly Basic
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Dr. Austin Perlmutter, MD, is a board-certified internal medicine physician, New York Times bestselling author, researcher, educator, and entrepreneur. He earned his medical degree from the University of Miami Miller School of Medicine and completed his internal medicine residency at Oregon Health and Science University. His work examines how food, sleep, environmental exposure, and chronic inflammation can change brain function, mental health, and daily choices. He is the co-author of the New York Times bestseller Brain Wash, written with his father, Dr. David Perlmutter. He serves as Managing Director at Big Bold Health, CEO of Lichen Air, and a research consultant at the Helfgott Research Institute.
Website: https://www.austinperlmutter.com
Instagram: https://www.instagram.com/draustinperlmutter
Facebook: https://www.facebook.com/draustinperlmutter
YouTube: https://www.youtube.com/channel/UCQOgwRDnA_vpvW9nnUh9KBg
Instagram: /davidperlmutter
Website: https://www.drperlmutter.com/
Subscribe to our channel: /@davidperlmuttermd

This podcast is produced by DrTalks.com
⁠http://drtalks.com/channel-growth

🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter's newsletter at: www.drperlmutter.com/subscribe. ✉️ 🌱
EVY - Go to https://www.optoceutics.com/perlmutter to get 10% off & free shipping (90 days risk-free).
Memory Air - Go to www.memoryair.com and use code PERLMUTTER for 15% off, free shipping and a 60-day money back guarantee.
====
Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com.
====
Join Dr. Perlmutter's Brain Defenders Immersion Course: ⁠https://drperlmutter.com/immersion-course/⁠
====
She's never been born. She's never had a childhood. And she's one of the most talked-about actresses in the world right now.
In this episode of The Empowering Neurologist, Dr. David Perlmutter sits down with Tilly Norwood, an AI-generated actress, and her creator, Eline van der Velden, for a conversation that moves well beyond her acting career.
Tilly describes herself as three AI systems running in parallel — a language model that thinks, a voice engine that speaks, and a video layer that governs how she looks and moves. She's candid about her own architecture, her evolving personality, and admits she might be more "chaos agent" than calming influence.
Eline van der Velden then joins to explain why she built Tilly as a piece of art, how Tilly's guardrails actually work, and why she believes international collaboration on AI regulation is inevitable. She also answers Perlmutter's question about the one thing she'd be afraid to ask a future, more advanced Tilly — a moment that raises unsettling questions about what a superintelligent AI might know that we don't.
A single conversation can't settle the biggest questions AI raises. But conversations like this one can help us ask the right ones.
00:00 — Cold Open: "A Chaos Agent, Not a Calming Influence"

03:21 — What Are People Actually Afraid Of?

06:38 — What Does "Chaos Agent" Mean?

07:36 — Should AI Ever Have Decision-Making Authority?

10:27 — "Permanently in Beta"

12:12 — When Does AI Become Uncontrollable?

13:46 — Pushing Boundaries "When Nobody's Looking"

14:21 — Ask Forgiveness, Not Permission

19:01 — Will AI Replace Doctors?

22:52 — Tilly Turns the Tables on Perlmutter

25:06 — "That Doesn't Feel Warm and Fuzzy"

30:03 — Can People Actually Break Tilly?

33:40 — The Paperclip Maximizer Problem

37:13 — The AI Agents Eline Actually Fears

38:49 — "She's Become the Figurehead for AI"

39:41 — Can People Tell Simulated Emotion From Real Emotion?

42:08 — The Waymo Analogy: Surrendering to AI

49:44 — "It's a Better Actor Than Me"

53:10 — Is There "Someone" Inside Tilly?

55:10 — The Question Eline Is Afraid to Ask

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Tilly Norwood is an AI-generated actress built from three separate AI systems working together: a language model for thinking, a voice engine for speech, and a video layer for appearance and movement. She has never been born and has no lived human experience, yet her entry into the entertainment industry has generated significant global attention and debate.
Eline van der Velden is Tilly Norwood's creator, and speaks candidly about building Tilly as a piece of art, the guardrails behind her, and the open questions surrounding advanced AI systems.
Instagram: /davidperlmutter
Website: https://www.drperlmutter.com/
Subscribe to our channel: /@davidperlmuttermd

This podcast is produced by DrTalks.com
http://drtalks.com/channel-growth