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SS-31 continues to be one of my favorite peptides of all time, and the more data that comes out on it, the more I think every person over 25 has a use case for it.
In this masterclass, I'm breaking down everything I know about SS-31. We cover what it actually does at the cellular level, why it's the first FDA-approved mitochondrial peptide, and why it works differently than almost every other peptide out there. No receptor binding. It goes inside your cells, binds to cardiolipin, and stabilizes the structure of your mitochondria.
I walk through the three dosing tiers I use with people, my take on cycling, why I run SS-31 before MOTS-c, how to stack it with GLPs, GH peptides, and the healing peptides, and what to actually track when you're on it. I also cover the troubleshooting stuff people ask me about constantly. Why don't I feel anything? Should I cycle? What about the headaches in the first two weeks?
If you're a clinician or just researching for yourself, this is the complete user's guide.
For entertainment purposes only.
Timestamps
00:00 Intro
01:00 What this masterclass covers
03:18 Why SS-31 matters and what makes it different
03:46 FDA approval and the Forzenity brand name
04:50 Peptide foundations and how SS-31 is made
05:52 The SS-31 sequence and the Seto-Schiller naming origin
06:40 Mitochondria 101 and why ATP matters
07:28 Mitochondrial dysfunction across chronic disease
08:34 Cardiolipin, cristae, and Barth syndrome
09:34 Why SS-31 is not a direct antioxidant
10:46 How SS-31 actually works (the upstream Godfather effect)
11:12 Why no receptor means no desensitization
13:36 Who SS-31 is for (mid-30s, athletes, post-illness, metabolic dysfunction)
14:24 Who should skip it
15:34 The three-tier dosing ladder
16:54 The FDA-approved 40mg dose and diminishing returns
19:08 Dosing by goal (longevity, performance, recovery, healing)
19:48 Cycling logic and the 8-12 week framework
20:22 When to dose (morning vs night)
21:24 What to expect and when (week-by-week timeline)
22:20 Why cycle if it doesn't desensitize
24:24 SS-31 before MOTS-c (the structural engineer vs operations manager)
26:18 Reconstitution and injection technique
28:22 What to track (subjective markers and biomarkers)
29:18 Stacking with MOTS-c, Humanin, BPC, GH peptides, and GLPs
31:28 Stacking for cognition and visceral fat
32:26 Troubleshooting "I don't feel anything"
33:54 Injection site reactions
34:36 When to discontinue and the first-two-week headache window
35:52 FAQ (legality, MitoQ comparison, oral routes, intranasal)
36:54 Use cases (weight loss, long COVID, athletic performance, TRT, kids)
37:54 Research grade vs pharmaceutical cost difference
38:22 Future outlook (AMD, sarcopenia, SBT-272, oral bioavailability)
40:30 Final thoughts and where SS-31 sits in the broader picture
42:20 Closing
USA