Treating periodontitis to improve overall health with Filippo Graziani
In the latest episode of the Next ReGeneration podcast, hosts Anina and Elena welcome Filippo Graziani, Professor of Periodontology at the University of Pisa, Italy. Together, they take you on a journey into the connection between oral and overall health, exploring how a healthy mouth can influence the entire body.
Graziani discusses research showing that periodontal therapy can significantly support glycaemic control in diabetic patients. He also highlights findings of oral bacteria in atheromatous plaques, illustrating the potential connection between periodontitis and cardiovascular disease.
Periodontitis can furthermore trigger systemic inflammation, thereby aggravating diabetes and increasing heart disease risk. In fact, 57 systemic diseases have already been associated with periodontitis, says Graziani.
As such, periodontal therapy not only improves patients’ quality of life — it may even support cognitive functions.
How far can periodontal treatment go in shaping general health outcomes?
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30:27
The role of epigenetics in oral regeneration with Farah Asa'ad
In the latest episode of the Next ReGeneration podcast, hosts Anina and Elena welcome Farah Asa'ad, an expert in epigenetics from the Sahlgrenska Academy at the University of Gothenburg, Sweden. Together they take you on a journey into epigenetics—the science of how lifestyle and external factors influence gene activity. From her award-winning research to the role of epigenetics in periodontitis and peri-implantitis, Asa'ad unpacks complex mechanisms in a way that’s easy to understand.
She explains how bacteria can alter the epigenetic profile of key immune genes, potentially leading to chronic inflammation and tissue destruction. Additionally, she discusses how epigenetic therapies, such as targeted drugs, could one day help restore oral health at a molecular level.
Could this be the future of personalised dentistry?
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27:45
Perio-Prostho synergy with Nadja Nänni
For the latest episode of the Next ReGeneration podcast hosts Anina and Elena welcome Nadja Nänni, a specialist in reconstructive dentistry from the University of Zurich in Switzerland. Together they explore the intricate relationship between periodontology and prosthodontics.
Nänni shares her perspective on removable versus fixed prostheses for periodontitis patients, and her hopes for future advancements in diagnosis and treatment. From optimising implant positioning and treatment planning to weighing up the pros and cons of screw-retained versus cement-retained restorations, this discussion is packed with valuable clinical insights.
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29:04
Oral health and elite sport performance with Ian Needleman
In the latest episode of the Next ReGeneration podcast, hosts Anina and Elena welcome Ian Needleman, Professor of Periodontology and Healthcare Research at UCL Eastman Dental Institute in London, UK. A passionate runner himself, Needleman has devoted substantial research to exploring the oral health of athletes and its impact on their performance and overall well-being.
Needleman shares fascinating insights from his assessments of athletes' oral health during the London 2012 Olympic Games. His studies consistently reveal that elite athletes frequently suffer from poor oral health, a phenomenon observed across both developing and developed nations. Although the exact mechanisms linking oral health to sports performance are not yet fully understood, inflammation seems to be a key factor. Needleman's research underscores that enhancing oral health can significantly boost athletic performance.
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36:35
The era of minimal invasiveness in tissue regeneration with Leonardo Trombelli
For the latest episode of the Next ReGeneration podcast in 2024 hosts Anina and Elena are joined by Leonardo Trombelli. He shares his unique perspective on how periodontal treatments and implant surgery have evolved throughout the years to become less invasive for patients.
Trombelli looks back on the serendipity moment when he came up with the idea of the single flap approach, that can be used to properly access many periodontal defects. He elaborates on taking advantage of the periosteum in peri-implant regenerative procedures and shares insights on how he came up with the Sub-periosteal peri-implant augmented layer (SPAL) technique to finally highlight his most recent idea of the pedicle periosteal flap.
The connective tissue of Trombelli’s career as a researcher and clinicians is his lifelong mission on making surgical procedures less complex and more accessible to clinicians of various skill levels, while at the same time reducing the invasiveness of the interventions for the patients.
Welcome to the “Next Re-Generation Podcast” by the Osteology Foundation. We feature hot topics and novel perspectives - always with relevance to the dental career and practice. Join our hosts Anina and Elena and as they speak with new guests from around the world each month, and learn more about what’s important for the next generation in oral regeneration.
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