Skip to content
Radio Logo
PodcastsTechnologyThis Week in AI

This Week in AI

Jason Calacanis
Latest episode

41 episodes

  • This Week in AI

    Alex Finn: Anthropic has the best model, Grok has the best harness | TWiAI 39

    11/12/2026 | 1h 10 mins.
    Thanks to our partner, @Paypal! Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at http://paypal.launch.co/

    Today’s show:
    Anthropic shipped Claude Fable 5.2. Panelist Alex Finn calls it a breakthrough on intelligence, speed, and cost at once, while noting that it’s still best to actually build things in Grok Bot, “by far the best harness on Planet Earth.” He actually asked Grok Bot, Claude Duet and ChatGPT Dots to send a $1,000 PayPal. Only Grok Bot got it done.
    TWiAI 39’s all star panel also includes Sara Hooker (co-founder & CEO of Adaption Labs) and Manu Sharma (co-founder & CEO of Labelbox). They’re discussing whether the model or harness matters more, and Sara observes that the entire Fable 5.2 roll-out is “almost entirely a story about cost.” Anthropic wants to own both the model and the harness so switching feels more painful.
    Manu explains why enterprises tend to remain locked in once IT wires up all their integrations… but Jason still feels his team drifting from Claude over to Grok Bot. So who wins in the end?
    PLUS: Anthropic sets its IPO range and drops new Claude office apps, Nvidia’s still investigating whether its CEO unethically sent extra chips to China, and are shadowy overseas interests behind the anti-data center push? The panel has some theories…
    Guests
    Sara Hooker on X: https://x.com/sarahookr
    Adaption Labs: https://adaptionlabs.ai/
    Manu Sharma on X: https://x.com/manuaero
    Labelbox: https://labelbox.com/
    Alex Finn on X: https://x.com/AlexFinn
    Henry Intelligent Machines: https://meethenry.ai/
    Relevant Links
    Anthropic releases Claude Fable 5.2 and Claude Mythos 5.2 ahead of IPO (CNBC): https://www.cnbc.com/2026/11/09/anthropic-claude-fable-5-2-mythos-5-2.html
    Claude's launch post: https://x.com/claudeai/status/2119867114450268322
    OpenAI launches GPT-6 Cyber with a higher API price than Anthropic and Google (VentureBeat): https://venturebeat.com/technology/openai-launches-gpt-6-cyber-with-stronger-exploit-research-and-higher-api-price-than-anthropic-and-google
    Grok Bot turns agents into persistent digital coworkers (VentureBeat): https://venturebeat.com/ai/spacexais-grok-bot-turns-agents-into-persistent-digital-coworkers-that-can-operate-your-apps-for-120-per-month/
    Hermes Agent (Nous Research): https://github.com/NousResearch/hermes-agent
    Anthropic sets IPO price range of $70 to $78 a share (TechCrunch): https://techcrunch.com/2026/11/10/anthropic-sets-ipo-price-range-of-70-to-78-per-share-to-reach-an-implied-valuation-of-1-404-trillion/
    Nvidia will investigate Jensen Huang's relationship with a possible Chinese spy (TechCrunch): https://techcrunch.com/2026/11/08/nvidia-says-its-investigating-ceo-jensen-huangs-relationship-with-possible-chinese-spy/
    Report: Alice Huang helped move $7.5B in Nvidia chips into China (Tom's Hardware): https://www.tomshardware.com/tech-industry/policy/alice-huang-reportedly-instrumental-in-securing-over-usd7-5-billion-of-nvidia-ai-gpu-imports-during-three-year-relationship-with-jensen-huang-helped-move-240-000-banned-chips-into-china-mostly-h100-and-h200
    An unexpected activist emerged to help block a $5 billion data center in Maryland (NPR): https://www.npr.org/2026/11/07/nx-s1-6007770/data-centers-activist-moratorium

    Timestamps:
    0:00 "Anthropic clearly has had a breakthrough"
    0:31 PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at https://paypal.launch.co
    9:41 Frontier models vs. smaller workhorse models
    11:18 Alex's PayPal agent test
    15:03 Enterprise lock-in and managed IT integrations
    20:39 Is Claude commoditizing SaaS?
    26:53 The $7.5B Nvidia chip report
    39:01 Do Chinese labs even need chips on the mainland?
    49:29 How export controls are like the War on Drugs
    58:51 How should data centers win Americans back?
    1:04:50 Attackers have the edge for now
  • This Week in AI

    Would you pay $1000/month for your agents? | TWiAI E38

    11/05/2026 | 1h 17 mins.
    Thanks to our partner, @Paypal! Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at http://paypal.launch.co/
    Today’s show:
    Grok Bot users maxed out their weekly limits over Halloween Weekend, and SpaceX now says that serving compute to all Bot-heads is financially unsustainable. So how much does AI have to cost for the math to actually line up? And is there anyone actually willing to pay?
    Jason says he’d spend about $1000/month for his personal bots, and the panel mostly aligns. (One outlier? Code Metal CEO Peter Morales, who just had a fight with his CTO over dropping $100K in tokens in just a few weeks.)
    On TWiAI Ep 38, our expert panel showcases their favorite recent AI builds and designs, plus breaks down more of the week’s biggest AI news and trends, including the chip stock selloff and debt squeeze on neoclouds, the AI advancements that are making mathematicians cry, and where LLMs actually get their news updates about major elections.
    Guests
    Peter Morales on X: https://x.com/PeterMoralesX
    Code Metal: https://www.codemetal.ai/
    Nick Harris on X: https://x.com/theanalognick
    Lightmatter: https://lightmatter.com/
    Mark Jeffrey on X: https://x.com/markjeffrey
    Stillcore Capital: https://stillcorecapital.com/
    Relevant Links
    Elon Musk throttles Grok Bot limits over "unsustainably high" costs (TechCrunch): https://techcrunch.com/2026/11/02/elon-musk-throttles-grok-bot-limits-due-to-unsustainably-high-costs/
    Elon's post on Grok Bot costs: https://x.com/elonmusk/status/2116992258520064397
    Goldman Sachs pulls AI coding tools from traders and bankers (The Decoder): https://the-decoder.com/goldman-sachs-pulls-ai-coding-tools-from-traders-and-bankers/
    Garry Tan spends up to $200K a year on tokens (TechCrunch): https://techcrunch.com/2026/11/02/y-combinators-garry-tan-uses-ai-agents-so-much-he-spends-up-to-200k-a-year-on-tokens/
    Jason's post: "< $40k a year on tokens… getting $2m+ in value": https://x.com/Jason/status/2117126320962351277
    Lovable: https://lovable.dev
    Notion: https://www.notion.com
    ElevenLabs: https://elevenlabs.io
    Bittensor: https://bittensor.com
    Tao Bubbles: https://taobubbles.net/
    Engy (subnet 53): https://subnetalpha.ai/subnet/engy/
    Athena, Jason's assistant service: https://athenawow.com
    Jason's "Unsponsored" Chrome extension for Amazon: https://x.com/Jason/status/2116380861167714594
    Sam Altman hates local AI models (Futurism): https://futurism.com/artificial-intelligence/sam-altman-hates-local-ai-models-computers
    Steven Strogatz on The Daily, "When A.I. Comes for Your Purpose in Life" (NYT): https://www.nytimes.com/2026/10/13/podcasts/the-daily/mathematicians-problem-ai-jobs.html
    Abbott halts data center approvals until audits are done (NBC DFW): https://www.nbcdfw.com/news/local/texas-news/data-center-approvals-in-texas-halted-until-audits-completed-gov-greg-abbott-says/4058445/
    How an obscure website became a force in America's election information machine (Washington Post): https://www.washingtonpost.com/technology/2026/10/30/how-an-obscure-website-became-force-americas-election-information-machine
    Google restricts Gemini from answering 2024 election questions (Quartz): https://qz.com/goggle-gemini-ai-chatbot-india-us-election-1851330306

    Timestamps:
    1:16 PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at https://paypal.launch.co
    3:00 How much should a company spend on AI?
    8:40 Engy, Lium, and the road to cheaper inference
    14:57 So what's the most you'd pay per month for your agents?
    22:06 How unmetered inference changes the way you work
    25:33 AI Agent Show & Tell
    38:57 Chip stocks sink, lenders pull back from neoclouds
    45:02 Dreaming of an agentic Christmas
    49:46 Sam Altman hates that you have DRAM
    55:01 Leaving math and science's Age of Heroes
    1:04:23 Where do the LLMs get election info?
    1:15:59 Subscribe to the TWiAI newsletter!
  • This Week in AI

    Anthropic’s Money Machine, “Slop” Degrees & the Meat Proxy | TWiAI Ep 37

    10/29/2026 | 1h 8 mins.
    This Week In Startups is made possible by:
    PayPal: https://paypal.launch.co
    Today’s show:
    Anthropic’s S-1 is finally out and it’s a beast: $16.3 billion in revenue in the first half of this year, up from $1.2 billion in 2025. Plus a $1.6 billion adjusted operating profit!
    Anthropic’s already at the front of a very fast-moving train, but Runlayer CEO Andy Berman points out that this journey’s just getting started. Only 2-3% of major enterprises are using AI as much as you’d think (at least, if you listen to this podcast), and everyone’s dragging their heels on connecting models to the kind of real-world business data that’s needed to truly super-charge results.
    Andy and Norm Ai founder John Nay join Jason and Lon to break down the filing, the agent explosion coming just over the horizon, and what happens to entry-level jobs and recent grads when intelligence is on tap?
    PLUS how to avoid becoming a “meat proxy,” why Andy suggests browser use is already solved, and why Reddit’s r/opensource community banned not just AI projects but non-native English speakers.
    Guests
    John Nay on X: https://x.com/johnjnay
    Norm Ai: https://www.norm.ai/
    Andy Berman on X: https://x.com/berman66
    Runlayer: https://www.runlayer.com/
    Relevant Links:
    Anthropic's S-1 (SEC): https://www.sec.gov/Archives/edgar/data/2130357/000162828026067168/anthropicpbc-sx1.htm
    Anthropic's risk factors include a "catastrophic AI-related incident" (WSJ): https://www.wsj.com/livecoverage/stock-market-today-dow-sp-500-nasdaq-10-26-2026/card/anthropic-s-risk-factors-include-catastrophic-ai-related-incident--aAwPiJrvIG5OHdQGAo1n
    Gallup's AI indicator: https://www.gallup.com/699797/indicator-artificial-intelligence.aspx
    Microsoft offers voluntary buyouts to 60,000 employees (CNBC): https://www.cnbc.com/2026/10/26/microsoft-msft-voluntary-buyouts.html
    Students at an A.I. School Were Supposed to Learn Faster. Many Aren't. (NYT): https://www.nytimes.com/2026/10/23/us/alpha-school-ai-education-parents.html?unlocked_article_code=1.K1E.IcJn.2l4XIQK5gQsl
    Meat Proxy: https://meatproxy.me/
    r/opensource just banned AI, non-English speakers, and more (The Verge): https://www.theverge.com/ai-artificial-intelligence/1018217/reddit-opensource-ai-ban
    When AI comes for your purpose in life, with Steven Strogatz (NYT): https://www.nytimes.com/2026/10/13/podcasts/the-daily/mathematicians-problem-ai-jobs.html
    Peter Thiel says AI will be "worse" for math people than word people (Fortune): https://fortune.com/2026/03/07/peter-thiel-ai-math-vs-word-skills-banks-smaller-headcounts/
    Timestamps:
    0:00 PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at https://paypal.launch.co
    1:43 What we learned from Anthropic's S-1
    9:30 Why only 2-3% of companies are really using AI
    18:03 Jason's "reverse to-do list" agent
    23:23 Will AI labs evolve beyond charging per token?
    32:36 Browser use is basically solved
    41:24 Are colleges giving performative "slop" degrees?
    53:00 Why r/opensource banned AI projects
    59:39 So what happens to the junior lawyers and analysts?
    1:06:01 Peter Thiel's "math people vs. word people" binary
    Subscribe to our newsletters on Substack:
    TWiST: https://twistartups.substack.com/
    TWiAI: https://www.thisweekinai.ai/
    TWiVC: https://thisweekinvc.substack.com/
    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp
    Follow Lon:
    X: https://x.com/lons
    Follow Jason:
    X: https://twitter.com/Jason
    LinkedIn: https://www.linkedin.com/in/jasoncalacanis
    Check out all our partner offers: https://partners.launch.co/
    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland
    Follow TWiST:
    Twitter: https://twitter.com/TWiStartups
    YouTube: https://www.youtube.com/thisweekin
    Instagram: https://www.instagram.com/thisweekinstartups
    TikTok: https://www.tiktok.com/@thisweekinstartups
    Substack: https://twistartups.substack.com
  • This Week in AI

    No One Likes Any of Sam Altman’s 3 AI Endgames | TWiAI E36

    10/22/2026 | 1h 13 mins.
    This Week In AI is made possible by PayPal: http://paypal.launch.co

    Today’s show:
    Sam Altman told OpenAI staff that there are only three ways for AI regulation to go: an international watchdog, every lab merging into one CERN-style entity, or one company getting so powerful that they “melt everyone else’s GPUs.”
    Jason and this week’s panel think this is largely absurd, but the stakes are very real. Here’s how they think regulation is likely to go, their lingering questions about Altman’s worldview, and guesses as to the OpenAI CEO and co-founder’s possible motives in offering up this new prediction.
    Plus:
    The US Government banned DeepSeek from every federal computer… What has them so spooked, and how does this impact US companies?
    Did ElevenLabs steal a YouTuber’s voice or is it all a misunderstanding.
    Why Chinese labs are ordering more chips than Nvidia can even produce.
    And more!

    Guests
    Jaleh Rezaei on X: https://x.com/jalehr
    Mutiny: https://www.mutinyhq.com/
    Alex Cheema on X: https://x.com/alexocheema
    EXO Labs: https://exolabs.net/

    Relevant Links
    DHS order banning DeepSeek (Federal Register): https://www.federalregister.gov/documents/2026/10/20/2026-21447/notice-of-order-regarding-exclusion-and-removal-of-deepseek-products-from-federal-civilian-executive
    DeepSeek’s DeepInfer on GitHub: https://github.com/deepseek-ai/DeepInfer
    Sam Altman’s 3 AI Endgames (The Information): https://www.theinformation.com/articles/altman-describes-three-endgames-ai-including-one-single-firm-melts-everyone-elses-gpus
    Chris Williamson’s ElevenLabs allegation (YouTube): https://www.youtube.com/watch?v=lxDNHLgWInU
    Archer voice actor response (YouTube): https://www.youtube.com/watch?v=C33AWhQwL1I
    Databricks CEO Ali Ghodsi on recursive self improvement (a16z): https://a16z.com/podcast/databricks-ceo-on-ai-pacing-cyber-risk-and-the-enterprise/
    Looking for backdoors in Jane Street LLMs (LessWrong): https://www.lesswrong.com/posts/a98MFPmqH54J2ayBn/looking-for-backdoors-in-jane-street-llms-1
    Exo turns 4 Mac Studios into a 4.8TB/s AI cluster (AlphaSignal): https://alphasignal.ai/news/exo-turns-four-mac-studios-into-a-4-8tb-s-ai-cluster

    Timestamps:
    0:00 Cold Open / Show Intro
    0:58 PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at https://paypal.launch.co
    2:56 How much hardware it takes to run local AI models
    4:32 DHS orders DeepSeek out of federal systems
    5:53 Why enterprise clients are uneasy about Chinese models
    9:47 Could an open-source model "phone home" to Beijing?
    14:10 Why enterprises are much more price sensitive about AI tools
    16:39 Are Sam Altman's AI endgame theories "deranged"?
    25:45 Why the major labs want more regulations
    26:28 The ElevenLabs Archer controversy continues
    34:30 Who actually owns the rights to your voice?
    45:17 "Substack for AI Models"
    46:20 China needs more chips than Nvidia can make
    52:40 Are enterprises running more local models?

    Subscribe to our newsletters on Substack:
    TWiST: https://twistartups.substack.com/
    TWiAI: https://www.thisweekinai.ai/
    TWiVC: https://thisweekinvc.substack.com/

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp
    Follow Lon:
    X: https://x.com/lons
    Follow Jason:
    X: https://twitter.com/Jason
    LinkedIn: https://www.linkedin.com/in/jasoncalacanis
    Check out all our partner offers: https://partners.launch.co/
    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

    Follow TWiST:
    Twitter: https://twitter.com/TWiStartups
    YouTube: https://www.youtube.com/thisweekin
    Instagram: https://www.instagram.com/thisweekinstartups
    TikTok: https://www.tiktok.com/@thisweekinstartups
    Substack: https://twistartups.substack.com
  • This Week in AI

    Why Fortune 500 Companies Are Quietly Switching to Open Models

    10/15/2026 | 49 mins.
    This Week In AI is made possible by:
    PayPal: http://paypal.launch.co

    Today’s show:
    Companies are spending $1 million on AI in a single month, but can’t always point directly to any resulting revenue. Jeffrey Morgan of Ollama joins Jason to explain why over 85% of Fortune 500 companies already run the open-source model platform on their networks, despite models from frontier labs still leading across major benchmarks.
    Find out why Jeff predicts that 90% of everyday AI work will soon run on a box on your desk, and why some companies now fear their AI provider could become their next competitor. Is AI alive? Jeff doesn’t think so. But that doesn’t mean there’s nothing to worry about.

    Guests:
    Jeffrey Morgan on X: https://x.com/jmorgan
    Ollama: https://ollama.com

    Relevant Links:
    Ollama, the easiest way to run open models locally and in the cloud → https://ollama.com
    Kimi K3 from Moonshot AI, the trillion-plus parameter open model Jeff mentioned → https://huggingface.co/moonshotai/Kimi-K3
    Reflection AI, the US open model lab Jeff is excited about → https://reflection.ai
    NVIDIA and Microsoft bring RTX Spark and DGX Station for Windows to the desktop (NVIDIA) → https://blogs.nvidia.com/blog/local-ai-rtx-spark-microsoft-windows-event/
    Introducing System One models and Jev, the decision model Jeff and Jason discuss (TypeSafe) → https://typesafe.ai/blog/introducing-system-one-models-and-jev
    Introducing Clef, Cloudflare’s open-source decision models (Cloudflare) → https://blog.cloudflare.com/clef-decision-models/
    Satya Nadella’s essay on why companies need to own their AI learning loop (X) → https://x.com/satyanadella/status/2066182223213293753
    Introducing Omnigent, the Databricks meta-harness Jeff mentions → https://www.databricks.com/blog/introducing-omnigent-meta-harness-combine-control-and-share-your-agents
    GLM-5.3 and the spread of advanced cyber capabilities (Anthropic) → https://www.anthropic.com/research/glm-5-3-and-the-spread-of-advanced-cyber-capabilities
    The Hugging Face incident and the road ahead (OpenAI) → https://openai.com/index/hugging-face-incident-and-the-road-ahead/

    Timestamps:
    0:43 PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at https://paypal.launch.co
    3:11 Why enterprises are getting token shock
    4:23 Can you trust the frontier labs with your data
    7:06 Why companies want to own their AI stack
    8:56 How close are open models to the frontier?
    11:57 Running real AI work on your own desk
    15:14 The Goldilocks zone and unmetered AI
    25:12 Decision models that replace code
    29:32 Who makes money when everything gets commoditized
    33:19 Why every enterprise is building its own router
    35:56 Can you depend on the frontier labs
    42:37 Sentient being or powerful software
    43:57 Open models, security, and the Hugging Face hack

    Subscribe to our newsletters on Substack:
    TWiST: https://twistartups.substack.com/
    TWiAI: https://www.thisweekinai.ai/
    TWiVC: https://thisweekinvc.substack.com/
    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

    Follow Jason:
    X: https://twitter.com/Jason
    LinkedIn: https://www.linkedin.com/in/jasoncalacanis

    Check out all our partner offers: https://partners.launch.co/

    Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

    Follow TWiST:
    Twitter: https://twitter.com/TWiStartups
    YouTube: https://www.youtube.com/thisweekin
    Instagram: https://www.instagram.com/thisweekinstartups
    TikTok: https://www.tiktok.com/@thisweekinstartups
    Substack: https://twistartups.substack.com
More Technology podcasts
About This Week in AI
An experts-only AI podcast: Think the 'All In' podcast for AI. Jason + 3 CEO-level experts breaking down the news & trends.
Podcast website

Listen to This Week in AI, The AI Daily Brief: Artificial Intelligence News and Analysis and many other podcasts from around the world with the radio.net app

Get the free radio.net app

  • Stations and podcasts to bookmark
  • Stream via Wi-Fi or Bluetooth
  • Supports Carplay & Android Auto
  • Many other app features
This Week in AI: Podcasts in Family