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This Week in Startups

Podcast This Week in Startups
Jason Calacanis
Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, ...

Available Episodes

5 of 1208
  • Coreweave IPO, AVRide & Digg is Back! | E2093
    This Week in Startups is brought to you by…Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twistHoratio. Visit https://www.hirehoratio.com/twist and get $2,000 off your initial set up.Today’s show: Jason and Alex cover CoreWeave’s filing for a $35 billion IPO after explosive revenue growth. But with 77% of its revenue coming from just two customers, is it built to last? Meanwhile, AVRide is bringing autonomous Hyundai robotaxis to Uber in Dallas, pushing the self-driving revolution forward as Waymo scales to 200,000 weekly rides. And finally, Digg is back! Kevin Rose and Alexis Ohanian are reviving the iconic social news platform, using AI-powered moderation to tackle Reddit’s biggest challenge. Tune in as Jason and Alex break it all down!Timestamps:(0:00) Episode teaser(1:34) Jason's South by Southwest appearances & All In fan meetups(4:17) Digg relaunch, history, and Kevin Rose's AI strategy(10:05) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(11:43) Jason’s involvement with Digg’s revival and lessons learned(15:02) Using Reddit for startup communities(20:00) Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(22:07) Kevin Rose's journey and ketamine therapy(24:18) CoreWeave's public filing, clients, and revenue growth(29:52) Horatio. Visit https://www.hirehoratio.com/twist and get $2,000 off your initial set up.(34:22) CoreWeave's potential acquisition and investor IRR(40:45) Using LLMs for financial analysis and political funding discussion(46:19) CoreWeave data centers and AV Ride partnership with Uber(50:18) Challenges in electric bikes and healthcare startups(53:10) Novo Nordisk's direct-to-consumer strategy with Wegovy(57:28) Future of healthcare and Brian Johnson's health regimen(1:05:52) Challenges and excitement in the autonomous vehicle industryLinks from episode:Check out digg: https://digg.com/Check out AVRide: https://www.avride.ai/robotCheck out the Mozi app: https://www.mozi.app/Check out Nerd Crawler: https://www.nerdcrawler.com/Check out article about Novo Nordisk and Wegovy: https://www.cnbc.com/2025/03/05/novo-nordisk-goes-direct-to-consumer-with-wegovy-what-it-means-for-obesity-rival-eli-lilly.htmlSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:05) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!(20:00) Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(29:52) Horatio. Visit https://www.hirehoratio.com/twist and get $2,000 off your initial set up.Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank SlootmanCheck out Jason’s suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.comSubscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916
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  • AI Agents & the Future of Work with LangChain’s Harrison Chase | AI Basics with Google Cloud
    In this episode: Jason sits down with Harrison Chase, CEO of LangChain, to explore how AI-powered agents are transforming the way startups operate. They discuss the shift from traditional entry-level roles to AI-driven automation, the importance of human-in-the-loop systems, and the future of AI-powered assistants in business. Harrison shares insights on how companies like Replit, Klarna, and GitLab are leveraging AI agents to streamline operations, plus a look ahead at what's next for AI-driven workflows. Brought to you in partnership with Google Cloud.*Timestamps:(0:00) Introduction to Startup Basics series & Importance of AI in startups(2:04) Partnership with Google Cloud & Introducing Harrison Chase from Langchain(4:38) Evolution of entry-level jobs & Examples of AI agents in startups(8:00) Challenges & Future of AI agents in startups(14:24) AI agents in collaborative spaces & Non-developers creating AI agents(18:40) Closing remarks and where to learn more*Uncover more valuable insights from AI leaders in Google Cloud's 'Future of AI: Perspectives for Startups' report. Discover what 23 AI industry leaders think about the future of AI—and how it impacts your business. Read their perspectives here: https://goo.gle/futureofai*Check out all of the Startup Basics episodes here: https://thisweekinstartups.com/basicsCheck out Google Cloud: https://cloud.google.com/Check out LangChain: https://www.langchain.com/*Follow Harrison:LinkedIn: https://www.linkedin.com/in/harrison-chase-961287118/X: https://x.com/hwchase17*Follow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanis*Follow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com
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  • US Crypto Reserve Bombshell, Ramp’s $13B Climb, & more | E2092
    Today’s show: Trump just floated the idea of a U.S. Crypto Reserve, suggesting a 10 bips transaction tax and naming unexpected altcoins like XRP, Solana, and Cardano. Jason and Alex break down what this means for crypto markets, regulation, and startups—plus the legal and political fallout. Is this a game-changer or just another pump-and-dump controversy?*Timestamps:(0:00) Alex and Jason kick of the show!(1:48) Trump's crypto policy and PR strategy(7:14) Analysis of Trump's proposed US crypto reserve(10:21) Gusto. Get three months free when you run your first payroll at http://gusto.com/twist(11:32) Predictions on legal challenges to Trump's crypto proposal(12:08) Industry reactions to the crypto tax proposal(20:27) OpenPhone. Get 20% off your first six months at https://www.openphone.com/twist⁠(22:26) Crypto report around market hours and Eric Trump's tweet(24:13) Predictions on Trump's future crypto policies and inflation impact(27:10) Trump's Truth Social and Crypto Investments dynamics(30:48) LinkedIn Jobs. Post your first job for free at https://www.linkedin.com/twist(31:05) Jason's alternative idea for a crypto tax(36:40) Ramp's funding and fintech sector growth(41:02) Discussion on investment performance and Jason's ETF idea(46:42) Challenges companies face with public offerings and market fairness(50:14) Potential CoreWeave IPO and high CapEx costs(54:39) Founder Hack from Matt Turck(57:12) Exploring hybrid business models*Links from the episode:Check out Angel University: https://www.angel.university/Check out the JCal Case Study at Stanford Business: https://www.gsb.stanford.edu/faculty-research/case-studies/jason-calacanis-case-study-creating-resourcesCheck out Arduino: https://www.arduino.cc/Check out Ramp: https://ramp.com/Check out Coreweave: https://www.coreweave.com/*Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcp*Follow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm*Follow Lon:X: https://x.com/LonsLinkedIn: https://www.linkedin.com/in/lonharris*Follow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanis*Thank you to our partners:(10:21) Gusto. Get three months free when you run your first payroll at http://gusto.com/twist(20:27) OpenPhone. Get 20% off your first six months at https://www.openphone.com/twist⁠(30:48) LinkedIn Jobs. Post your first job for free at https://www.linkedin.com/twist*Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland*Check out Jason’s suite of newsletters: https://substack.com/@calacanis*Follow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com*Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916
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  • Board Talk Empire with GRIN's Brandon Brown, Founder Hacks & SEC Memecoin Clarity? | E2091
    Today’s show: Jason and Alex break down the latest head-scratching SEC ruling on meme coins—did they just legalize pump-and-dumps to protect Trump’s token? Plus, they dive into why venture debt can destroy startups, the rise of AI-driven companies, and how Tesla is gearing up to challenge Waymo in the self-driving car race. Then, Brandon Brown from GRIN joins the show to talk about scaling to 8-figure revenue, surviving brutal market corrections, and why he’s stepping down as CEO after a decade. This one’s packed with insights for founders, investors, and anyone watching the future of crypto, startups, and AI unfold.*Timestamps:(0:00) Jason and Alex kick off the show!(1:39) Palmer Luckey feud, and supporting Trump in Silicon Valley(9:36) AI's impact on startup growth and job displacement(10:11) Paddle. Go to https://www.paddle.com/twist to get started with your exclusive listener fee-free period.(12:20) Product market fit and Salesforce productivity(15:01) Howey Test and its application to cryptocurrencies(20:07) LinkedIn Ads. Get a $100 LinkedIn ad credit at http://www.linkedin.com/thisweekinstartups(26:13) Jason's libertarian views on meme coins(31:13) Hubspot for Startups. Get up to 75% off plus 3 months of Perplexity AI for free. Go to https://www.hubspot.com/startups(32:16) Meme coin regulation and political implications(37:22) GRIN's Brandon Brown interview and company evolution(46:10) Leadership changes and challenges at GRIN(53:28) Venture debt risks and business cycle preparedness(59:00) Leadership skills and defining reality(1:04:13) Updates on Waymo and autonomous rides(1:09:06) Tesla and the global autonomous vehicle market*Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcp*Check out GRIN: https://grin.co/Checkout Angel University with Jason Calacanis & Mike Savino: https://www.angel.university/Check out the Founder Friday City Competition: https://www.founderfridays.tech/city-competition*Follow BrandonX: https://x.com/Brandon_BrownLinkedIn: https://www.linkedin.com/in/brandon-brown-0898731/*Follow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm*Follow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanis*Thank you to our partners:(10:11) Paddle. Go to https://www.paddle.com/twist to get started with your exclusive listener fee-free period.(20:07) LinkedIn Ads. Get a $100 LinkedIn ad credit at http://www.linkedin.com/thisweekinstartups(31:13) Hubspot for Startups. Get up to 75% off plus 3 months of Perplexity AI for free. Go to https://www.hubspot.com/startups*Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland*Check out Jason’s suite of newsletters: https://substack.com/@calacanis*Follow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com*Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916
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  • The Incredible Double Interview: Superhuman and Robinhood | E2090
    Today’s show: Jason interviews Rahul Vohra, CEO and founder of Superhuman, and Vlad Tenev, CEO and co-founder of Robinhood. This is a packed episode featuring founder tips, fun stories about how Superhuman and Robinhood got their start and much more!Timestamps:(0:00) Episode teaser(2:13) Product market fit and founder journeys(3:25) Jason's investment in Superhuman and market positioning(5:14) AI's role and features in Superhuman(10:25) Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(14:37) Targeting users and competitive advantages(22:23) Evolution and new features of Superhuman(20:52) Northwest Registered Agent. Get more privacy, more options, and more done—visit northwestregisteredagent.com/twist today!(24:37) Tackling spam with Superhuman's AI(27:05) Custom auto labels and email classification(29:47) Vapi. Go to Vapi.ai and use code Twist200 to get $200 in credits(32:03) Superhuman's auto reminders and drafts(34:14) Vlad Tenev and the origins of Robinhood(39:31) Product design philosophies of Robinhood and Superhuman(49:29) Scaling design principles and investment decisions(52:31) Subjectivity in product design(55:14) Customer feedback in product development(1:00:00) Superhuman's subscription model and customer acquisition(1:05:11) PR strategies and news hijacking(1:12:06) Investment experiences with Robinhood(1:13:35) Navigating company valuation fluctuations(1:15:03) Influences on Vlad Tenev and new Robinhood desktop product(1:22:02) Company resilience and employee reorganization(1:25:52) Crypto regulation and startup mentality(1:30:05) Investment trends among Robinhood users(1:31:12) Retail benefits for startups and capital raising challenges(1:34:04) Accreditation for private investing and solutionsSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpLinks from this episode:Check out Superhuman: https://superhuman.com/Check out Superhuman’s blog post that details all of the new features Rahul went over in the demo: https://blog.superhuman.com/the-next-superhuman-ai/. Check out Robinhood Legend: https://robinhood.com/us/en/legend/Article “How Superhuman Built an Engine to Find Product Market Fit”: https://review.firstround.com/how-superhuman-built-an-engine-to-find-product-market-fit/Check out Rick Rubin’s book: https://www.amazon.ca/Creative-Act-Way-Being/dp/0593652886Article on Bezos and Washington Post: https://www.newsweek.com/bezos-makes-big-change-washington-post-opinion-focus-endorsed-musk-2036618Media Bias Chart: https://www.allsides.com/media-bias/media-bias-chartCheck out “Working Backwards” book about Amazon insights: https://www.amazon.ca/Working-Backwards-Insights-Stories-Secrets/dp/1250267595Check out Rahul’s article on acquisition: https://www.linkedin.com/pulse/rip-mailbox-founders-how-stop-worrying-love-being-acquired-vohra/Follow Rahul:X: https://x.com/rahulvohraLinkedIn: https://www.linkedin.com/in/rahulvohra/Follow Vlad:X: https://x.com/vladtenevLinkedIn: https://www.linkedin.com/in/vlad-tenev-7037591b/Follow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisThank you to our partners:(10:25) Lemon.io. Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist(20:52) Northwest Registered Agent. Get more privacy, more options, and more done—visit northwestregisteredagent.com/twist today!(29:47) Vapi. Go to Vapi.ai and use code Twist200 to get $200 in credits
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About This Week in Startups

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.
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