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189 episodes
The Startup Run by AI Agents
2/12/2026 | 54 mins.Evan Ratliff co-founded a publishing startup in 2011. Now he hosts a podcast called Shell Game. In the latest season of the show, Evan creates a company run by AI agents. The project is absurdly funny – Evan calls it an office satire – but it also illuminates the power and limits of AI agents.
See omnystudio.com/listener for privacy information.Can AI Help Solve Alzheimer’s?
2/05/2026 | 33 mins.Patrick Hsu is the co-founder of Arc Institute, which is integrating AI models and biological research. Patrick’s problem is this: How can you use AI to make biological research more efficient – and ultimately to find cures for Alzheimer’s and other complex diseases?
See omnystudio.com/listener for privacy information.The New Science of Preventing Heart Attacks
1/29/2026 | 32 mins.In recent decades, medical research has fundamentally changed how we think about heart disease. This fresh understanding has opened up new ways to prevent heart attacks. Eric Topol is a cardiologist and the founder of the Scripps Research Translational Institute in San Diego. Eric’s problem is this: How can doctors use recent technological developments to do a better job at preventing heart attacks?
See omnystudio.com/listener for privacy information.From Solar Pumps to Everything: Building a Market from Scratch
1/22/2026 | 40 mins.Samir Ibrahim is the co-founder and CEO of SunCulture. When he started the company, he thought he was solving a simple problem: How do you sell solar-powered pumps to help poor farmers irrigate their land? It turned out, he was working on something much bigger: How do you help poor farmers get richer, and create a giant new market from scratch?
See omnystudio.com/listener for privacy information.Mass-Producing Stem Cells to Cure Disease
1/15/2026 | 34 mins.Nabiha Saklayen is the co-founder and CEO of Cellino. Nabiha’s problem is this: How can you make personalized stem cell therapies quickly and cheaply?
 Induced pluripotent stem cells, or IPSCs, have shown tremendous promise as treatments for illnesses like Parkinson’s, leukemia, and heart disease.
On today’s show, Nabiha explains why IPSC manufacturing is still mostly done by hand, how her background in physics and lasers led her into biology, and what it takes to try and build tiny, automated cell factories.
See omnystudio.com/listener for privacy information.
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About What's Your Problem?
Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with entrepreneurs and engineers tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better.
iHeartMedia is the exclusive podcast partner of Pushkin Industries.
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