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What's Your Problem?

iHeartPodcasts and Pushkin Industries

Business Technology

Latest episode

190 episodes

The Killer We Refused to See
2/19/2026 | 39 mins.
After bacteria were discovered, it took scientists 200 years to figure out that they cause disease. If scientists had made the link sooner, hundreds of millions of lives could have been saved.
In his recent book So Very Small, Tom Levenson, a professor of science writing at MIT, tells the amazing story of germ theory, and argues that our worldview can prevent us from seeing what is right in front of us – even when lives are at stake.
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The Startup Run by AI Agents
2/12/2026 | 54 mins.
Evan Ratliff co-founded a publishing startup in 2011. Now he hosts a podcast called Shell Game. In the latest season of the show, Evan creates a company run by AI agents. The project is absurdly funny – Evan calls it an office satire – but it also illuminates the power and limits of AI agents.
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Can AI Help Solve Alzheimer’s?
2/05/2026 | 33 mins.
Patrick Hsu is the co-founder of Arc Institute, which is integrating AI models and biological research. Patrick’s problem is this: How can you use AI to make biological research more efficient – and ultimately to find cures for Alzheimer’s and other complex diseases?
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The New Science of Preventing Heart Attacks
1/29/2026 | 32 mins.
In recent decades, medical research has fundamentally changed how we think about heart disease. This fresh understanding has opened up new ways to prevent heart attacks. Eric Topol is a cardiologist and the founder of the Scripps Research Translational Institute in San Diego. Eric’s problem is this: How can doctors use recent technological developments to do a better job at preventing heart attacks?
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From Solar Pumps to Everything: Building a Market from Scratch
1/22/2026 | 40 mins.
Samir Ibrahim is the co-founder and CEO of SunCulture. When he started the company, he thought he was solving a simple problem: How do you sell solar-powered pumps to help poor farmers irrigate their land? It turned out, he was working on something much bigger: How do you help poor farmers get richer, and create a giant new market from scratch?
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About What's Your Problem?

Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with entrepreneurs and engineers tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better. iHeartMedia is the exclusive podcast partner of Pushkin Industries.

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Business Technology Entrepreneurship