Personalized Medicine and the Next Frontier for Movement Disorders
Welcome back to The Caring Neurologist! In this milestone 10th episode, “The Future of Genetic Therapy in Movement Disorders,” the ever-insightful Dr. Sandeep Thakkar unravels the science and hope behind gene therapy for Parkinson’s disease and beyond. They break down what gene therapy really means, going beyond the headlines and “science fiction” buzzwords like CRISPR to explain how this groundbreaking approach aims to address the very root causes of movement disorders.Dr. Thakkar shares the latest updates on clinical trials for therapies targeting genetic mutations like GBA1, and discusses how viral delivery systems and gene editing are shaping the next wave of Parkinson’s treatments. The conversation moves from technical breakthroughs to bigger questions about safety, personalized medicine, real-world challenges, and the immense hope these advances offer for patients and families.Whether you’re living with Parkinson’s, care for someone who is, or are just fascinated by the future of medicine, this episode will leave you feeling both grounded and inspired. Stay tuned for an episode that’s as informative as it is hopeful!00:00 Gene Therapy Advances03:28 Gene Therapy for Parkinson's07:24 Gene Editing: CRISPR Explored12:43 GBA1 Mutation in Parkinson's Disease16:15 Gene Therapy: A Parkinson's Update17:09 Revolutionizing Care in Neurology21:26 Gene Therapy Advancements in Huntington's Disease26:17 Gene Therapy Delivery Challenges29:43 Genetic Insights in Parkinson's Prevention33:23 Understanding Future Changes in Gene Therapy36:16 Balance Excitement and Challenges37:37 Ozzy Osbourne's Impactful LegacyThe Caring Neurologist - Podcast Website - https://thecaringneurologist.com/ Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/ Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/ TopHealth - https://tophealth.care/
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39:24
Feeding the Mind: How Diet and Toxins Shape Brain Health and Prevent Disease
Welcome to another episode of The Caring Neurologist! In today’s insightful conversation, Dr. Sandeep Thakkar's talks about what Diet and Toxins Reveal About Brain Health. As one of the most-heard video podcasts in neurology, this episode tackles the crucial, and often misunderstood links between nutrition, environmental toxins, and brain health, especially for those living with Parkinson’s and movement disorders.Dr. Thakkar explores how what we eat truly acts as medicine for the mind, breaking down the science behind everyday foods, healthy eating patterns, and why your grocery list matters more than ever. They discuss the impact of processed foods, why the “Mediterranean” and “MIND” diets win out, and offer practical advice for anyone feeling overwhelmed by conflicting dietary guidance and environmental health news. Whether you’re looking for clear advice on what to eat, how to minimize exposure to harmful substances, or realistic steps to improve your nutrition, this episode serves as a friendly guide to boosting your brain’s health one bite at a time.Grab your favorite snack (just maybe skip the breakfast pizza), and join us for a relatable, evidence-based conversation designed to empower you on your journey to better brain health!00:00 "Food as Fuel and Medicine"05:00 Supporting Brain Health with Nutrition08:39 Small Changes for Lasting Success12:39 "Foods Harmful to Brain Health"16:29 Pesticides, Farming, and Parkinson's Link19:23 Water Contamination Awareness & Action23:22 Choosing Clean Over Costly Organic26:36 Consistent Healthy Eating Mindset29:53 Sweets Worsen Parkinson's Symptoms32:26 Enhanced Food Label Clarity36:52 "Boost Health with Habits"38:27 Artificial Sweeteners and Health ConcernsThe Caring Neurologist - Podcast Website - https://thecaringneurologist.com/ Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/ Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/ TopHealth - https://tophealth.care/
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40:39
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40:39
Beyond Genetics: Why Environmental Exposures Like Pesticides Matter in Parkinson’s Disease
Welcome to the eighth episode of The Caring Neurologist with Dr. Sandeep Thakar! In this thought-provoking conversation, Dr. Thakkar dives into the alarming links between Parkinson’s disease and environmental toxins, specifically the pesticides used at golf courses and in our own backyards. Inspired by a recent JAMA Neurology study, they unravel how living near manicured greens could impact long-term brain health, what specific chemicals are involved, and why these risks matter far beyond just golfers. Together, they answer pressing questions about real-life risk, discuss practical steps you can take to protect yourself and your loved ones, and challenge us all to advocate for stronger public health measures, without giving in to panic. Whether you’re a concerned parent, a public health enthusiast, or just curious about what’s really in your water, this episode will empower you with knowledge and leave you with actionable advice. Tune in to find out what might be hiding in your backyard, and what you can do about it.00:00 Golf Course Proximity and Parkinson's Risk04:25 Golf Course Pesticide Safety Concerns08:30 Pesticides Cause Nervous System Damage10:44 Pesticide Exposure and Brain Damage15:47 Mindful Awareness of Water Safety17:52 Environmental Safety Concerns in Golf Courses20:22 "Concerns Over Industrial Farming Practices"26:06 Diet, Chemicals, and Antibiotic Concerns29:13 "Evaluating Food Safety and Diets"31:16 Air and Car Pollution ConcernsThe Caring Neurologist - Podcast Website - https://thecaringneurologist.com/ Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/ Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/ TopHealth - https://tophealth.care/
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32:24
From the Gut to the Brain: Understanding Parkinson’s Progression and Research Breakthroughs
Welcome to episode seven of The Caring Neurologist, where hosts Dr. Sandeep Thakkar dives deep into the world of Parkinson’s disease, this time shining a spotlight on the cutting edge of clinical research. In this episode, Dr. Thakkar explains why research and care are inseparable for truly advancing Parkinson’s treatment, and opens up about the most exciting developments shaping the field today.From discussing the importance and process of clinical trials, to breaking down how gene therapy, artificial intelligence, and novel therapies like stem cells are transforming what’s possible for Parkinson’s patients, this conversation is packed with hope and real-world insights. Dr. Thakkar shares his unique perspective as both a hands-on physician and research leader, offering a glimpse into promising new studies and explaining how patients can get involved in shaping the future of care.If you or a loved one are navigating Parkinson’s or just curious about how research becomes real-life treatment breakthroughs, this episode is filled with practical wisdom, encouragement, and a peek at the innovations on the horizon. So grab your notebook and get ready to be inspired by Dr. Thakkar’s passion and expertise, as he remind us why curiosity, partnership, and patient empowerment are the driving forces behind progress.Timestamps:00:00 FDA Clinical Trial Phases07:20 Advancements in Parkinson's Research09:49 AI in Pharma: Molecular Insights12:48 Parkinson's Research Developments17:50 Parkinson’s as a Proteinopathy20:53 Clinical Trial Participation Considerations25:55 Pharma Influence on Politics29:46 Parkinson’s Care and Research Hub32:05 Purpose-Driven Career34:16 Recording End AcknowledgmentThe Caring Neurologist - Podcast Website - https://thecaringneurologist.com/ Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/ Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/ TopHealth - https://tophealth.care/
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34:33
How DBS Restores Quality of Life for Parkinson’s Patients and More
Welcome to episode six of The Caring Neurologist! In this episode, Dr. Sandeep Thakkar dives deep into a truly life-changing topic: Deep Brain Stimulation (DBS). While the phrase might sound futuristic or even a little intimidating, DBS is a reality for thousands of people living with Parkinson’s disease and other neurological conditions. Dr. Thakkar unpacks what DBS really is, how it works, and why it’s become such a promising treatment option for managing symptoms like tremor and stiffness when medications are no longer enough.Dr. Thakkar shares his clinical experiences, the science behind DBS, who might be a candidate, and what patients can expect every step of the way - from evaluation through surgery to life after DBS. With patient stories, practical advice, and a look ahead at new advances like adaptive DBS, this episode sheds light on a therapy that is giving patients and families real hope and renewed quality of life.If you’ve ever wondered what it’s like to consider or live with DBS, or just want to hear about some of the most exciting technology at the intersection of neurology and care, this episode is for you. Tune in to discover how science fiction is becoming science fact -and hear firsthand just how transformative advances in neurological care can be.Timestamps:00:00 Fulfillment in Evolving Medicine04:15 Parkinson's Dopamine and Brain Stimulation07:38 Brain Stimulation Device Programming11:36 Optimal Timing for Deep Brain Stimulation13:41 From Epilepsy to Movement: A Journey16:30 Deep Brain Stimulation Process21:29 Deep Brain Stimulation Overview23:57 Early Intervention in Brain Surgery26:58 Adjustable Facial Stimulation Therapy31:44 Balancing Medication and Well-being35:07 Choosing Parkinson's Care and Trials38:14 Weighing DBS Surgery Risks39:52 "Deep Brain Stimulation Insights"43:19 Deep Brain Stimulation for EpilepsyThe Caring Neurologist - Podcast Website - https://thecaringneurologist.com/ Dr. Sandeep Thakkar - LinkedIn - https://www.linkedin.com/in/sandeep-thakkar-do-798a2499/ Dr. Sandeep Thakkar - Clinic - https://ocparkinsons.com/about-mdpds/our-team/dr-thakkar/ TopHealth - https://tophealth.care/
“The Caring Neurologist" - By Dr. Sandeep Thakkar is a podcast exploring the science, stories, and breakthroughs shaping the lives of those with Parkinson’s and movement disorders. Join Dr. Thakkar as he blends cutting-edge science with compassionate storytelling to empower patients, caregivers, and providers.
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