Longevity Roadmap

• 164: Young Blood Can Rejuvenate Old Brains with Dr. Tony Wyss-Coray

  In this episode, we are joined by Dr. Tony Wyss-Coray to discuss his groundbreaking research on brain resilience and aging. He explains how systemic factors, particularly proteins in the blood, influence cognitive function and the aging process. The discussion covers the role of proteomics, machine learning, and the potential of parabiosis and plasma infusions in developing therapies for age-related diseases like Alzheimer's. Dr. Wyss-Coray emphasizes the importance of understanding the biological markers of aging and resilience to create targeted interventions for healthier aging. Learn more about Dr. Wyss-Coray:  https://brainresilience.stanford.edu/  https://www.verobioscience.com/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

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• 163: How Mitochondrial Decline Drives Brain Aging with Dr. Francisco Gonzalez-Lima

  In this episode, we are joined by Dr. Francisco González-Lima to delve into the metabolic mechanisms that drive brain aging and cognitive decline. He begins by outlining how reductions in cytochrome oxidase activity, disruptions in oxidative phosphorylation, and the accumulation of mitochondrial mutations progressively impair neuronal energy metabolism. These metabolic deficits, he explains, often emerge long before the structural abnormalities associated with Alzheimer's disease. Building on this foundation, the conversation examines how reactive oxygen species, mitochondrial inefficiency, and altered cortical oxygen utilization contribute to diminished cognitive resilience over time. Dr. González-Lima highlights why these metabolic disturbances provide a more coherent explanation for geriatric dementia than traditional protein-centric models. The discussion then shifts to emerging therapeutic strategies. Dr. González-Lima reviews evidence for low-dose methylene blue and 1064 nm transcranial photobiomodulation, both of which appear to enhance mitochondrial respiration and support prefrontal function by directly targeting cytochrome oxidase activity. He concludes by emphasizing the need for metabolism-focused interventions, improved cerebral perfusion, and more precise energy-based frameworks to guide the future of brain-aging therapeutics. Learn more about Dr. Francisco González-Lima: https://liberalarts.utexas.edu/psychology/faculty/fg - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

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• 162: The Habits of Healthy Aging with Dr. Kate Wolin

  We are joined by behavioral epidemiologist Dr. Kate Wolin to unpack why so many health interventions collapse outside the lab—and what actually drives lasting change in the real world. From frictionless habit design and daily self-monitoring to movement, sleep, and the muscle-preserving realities of GLP-1s, she reveals the behavioral strategies that truly move the needle on long-term metabolic and overall health. Watch the full episode to learn how evidence-based behavior science can transform your healthspan. Learn more about Dr. Kate Wolin: https://drkatewolin.com/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

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• 161: The Future of Tissue Regeneration with Dr. Jennifer Elisseeff

  In this episode, we are joined by Dr. Jennifer Elisseeff to discuss the evolving field of tissue engineering and its applications in regenerative medicine. She explains the shift from using stem cells to focusing on immune cells for tissue repair, the challenges of regenerating cartilage, and the importance of vascularity in tissue health. The discussion also covers the impact of aging on tissue repair, the role of senescent cells, and the future of personalized medicine in tissue engineering. Dr. Elisseeff emphasizes the need for innovative approaches and the integration of immunotherapies to enhance tissue repair processes. Learn more about Dr. Jennifer Elisseeff: https://www.bme.jhu.edu/people/faculty/jennifer-h-elisseeff/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

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• 160: Molecular Secrets of Aging Told Through Worms with Dr. Heidi Tissenbaum

  Dr. Heidi Tissenbaum, a molecular geneticist at UMass Chan Medical School, joins Dr. Buck Joffrey to explore what C. elegans worms have revealed about the biology of aging. She explains how these simple organisms helped uncover key longevity pathways—like insulin/IGF-1 signaling and sirtuins—that also exist in humans. The conversation dives into the balance between stress and resilience, the role of IGF-1 in muscle health and lifespan, and why she believes true longevity breakthroughs will require understanding how the body's systems communicate as a whole. Learn more about Dr. Heidi Tissenbaum: https://profiles.umassmed.edu/display/133231 - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com

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