In this episode, Professor Peter McCaffery joins Dr. Buck Joffrey to discuss the multifaceted role of Vitamin A in brain health, particularly its function as a signaling molecule that influences neuroplasticity and cognitive functions. He elaborates on the challenges of Vitamin A supplementation, especially in aging populations, and the implications of retinoic acid signaling in neurodegenerative diseases like Alzheimer's. The discussion also touches on the importance of skin health in the context of systemic aging and the potential for targeted therapies to enhance Vitamin A signaling without the risks associated with traditional supplementation. Learn more about Professor Peter McCaffery: https://www.abdn.ac.uk/people/peter.mccaffery - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/
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36:34
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36:34
151: Does Astaxanthin Increase Longevity?
In this episode, Dave Watumull joins Dr. Buck Joffrey to discuss the benefits and mechanisms of astaxanthin, a powerful antioxidant and anti-inflammatory compound. He explains its role in longevity, particularly through the Interventions Testing Program (ITP), where astaxanthin was shown to extend lifespan in male mice by 12%. The discussion also covers the safety profile, bioavailability, and clinical studies demonstrating cardiovascular benefits. Gender differences in efficacy are explored, along with practical advice on dosage and where to find astaxanthin products. Learn more about AX3: https://ax3.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/
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41:48
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41:48
150: The Microbiome’s Role in Aging and Healthspan
Dr. Sean Gibbons joins Dr. Buck Joffrey to discuss the complexities of the gut microbiome, its evolution, and its significant role in health and longevity. He explains how our microbiome is established at birth, how it changes throughout life, and the impact of diet and lifestyle on its composition. The discussion also covers the challenges of modifying the microbiome, the potential of precision nutrition, and the emerging field of fecal transplants. Dr. Gibbons emphasizes the importance of butyrate, a beneficial short-chain fatty acid produced by gut bacteria, and the future of microbiome research in developing targeted interventions for health improvement. Learn more about Dr. Sean Gibbons: https://isbscience.org/people/sean-gibbons-phd/?tab=biography - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/
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40:14
149: How Dental Health Impacts Longevity
Dr. Ellie Phillips, DDS, joins Dr. Buck Joffrey to explain how oral pathogens contribute to chronic inflammation and conditions such as cardiovascular disease, Alzheimer’s, and adverse pregnancy outcomes. She shares the science behind xylitol, saliva-driven remineralization, and practical strategies for supporting a healthy oral microbiome to reduce systemic risk. Learn more about Dr. Ellie Phillips: https://drellie.com/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/
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148: Dr. Kevin J. Tracey - Stimulating the Vagus Nerve to Reduce Inflammation and Improve Healthspan
Dr. Kevin J. Tracey, neurosurgeon, immunologist, and pioneer in bioelectronic medicine, discusses the discovery of the inflammatory reflex and how vagus nerve stimulation can precisely regulate immune activity without immunosuppression. He explains its clinical application in rheumatoid arthritis, potential use in Crohn’s disease, multiple sclerosis, and metabolic disorders, and its implications for extending healthspan. Watch the full episode to explore how targeting neural circuits could redefine the treatment of inflammation. Get Dr. Kevin J. Tracey's book, The Great Nerve: https://www.penguinrandomhouse.com/books/746339/the-great-nerve-by-kevin-j-tracey-md/ Learn more about Dr. Tracey: https://feinstein.northwell.edu/institutes-researchers/our-researchers/kevin-j-tracey-md - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/
Dr. Buck Joffrey sits down with leading scientists in the field of longevity to explore cutting-edge research, emerging therapies, and what it really takes to live longer—healthier.
USA