PodcastsHealth & WellnessPeptide of The Week

Peptide of The Week

JD Denham and Will Haas
Peptide of The Week
Latest episode

54 episodes

  • Peptide of The Week

    Peptide of the Week: Industry Update – Retatrutide, GLP-1s & FDA Moves Explained

    12/22/2025 | 23 mins.

    Welcome back, warriors! In this week’s special episode of Peptide of the Week, JD Denham and William T. Haas are joined by peptide researcher and clinical expert Paul Bakhtiar to break down the biggest developments shaking up the entire peptide industry.From FDA crackdowns to the future of GLP-1s like Retatrutide, this episode gives you the real insider breakdown of what’s happening, why it matters, and what you should do right now if you’re using or selling peptides.We cover:⚠️ Retatrutide: What’s changing & when– Big Pharma is moving fast to monopolize Retatrutide via FDA approval– Once approved, it will no longer be available through research-use sites– Access will be limited to prescription only via 503A/503B pharmacies & telehealth– Expect price increases of 50–100% compared to current availability💉 What does this mean for GLP-1 users?– Stock up NOW if you’re using Retatrutide (powder can last 2+ years unreconstituted)– Semaglutide & Tirzepatide may still be available for a time, but not forever– New rules are expected by Q1 2026, if not sooner– Telehealth will become the main legal route for GLP-1s and other “controlled” peptides📉 What about other peptides (BPC-157, TB-500, MOTC, etc.)?– The FDA is quietly reclassifying peptides as “biologics” to open them up for patents– 25–40 peptides are expected to become FDA approved in the next 12–18 months– Research-use availability will continue for now, but eventually move to doctor-prescribed only💣 Why this proves peptides are the real deal– Peptides work that’s why Big Pharma is jumping in– The move to medicalize & retailize peptides is proof they’re not fringe they’re the future– Good news: this also removes bad actors & fake COAs from the market📌 Whether you’re a casual user or deep in the industry this episode is a must-listen for truth over headlines and clarity over fear.💬 Got questions? Drop them in the comments and we’ll keep unpacking this in future episodes.📺 Subscribe for weekly deep dives into the truth about performance, healing, and longevity. No fluff. No fear. Just facts.Stay Connected & Follow Us!JD's Instagram: https://www.instagram.com/jd_denham_fitJD's Facebook: https://www.facebook.com/people/JD-Denham/61563578940850/Wills Instagram: https://www.instagram.com/williamthaas/Paul Bakhtiar's Instagram: https://www.instagram.com/paulbakhtiar/

  • Peptide of The Week

    Peptide Q&A #20 – Bikini Prep Stacks, 2026 Peptide Restrictions, TRT Cycles & Long-Term Peptide Use

    12/18/2025 | 1h 5 mins.

    Welcome back, warriors! In this week’s Peptide Q&A, JD Denham and William T. Haas break down real-world protocols, competition prep, hormone optimization, longevity stacks, and what may be coming next for the peptide industry. No fluff. No scripts. Just straight talk from experience.We cover:💪 Bikini Competitor Fat Loss: RETA dosing, Tesamorelin, SLU-PP-332, NAD+, glutathione, and how to tighten up without steroids🩸 PCOS & Cycle Changes: Why RETA may help restore menstrual cycles and improve skin quality in female athletes🔥 Getting Leaner on Prep: When to increase RETA, add 5-Amino-1-MQ, L-Carnitine alternatives, and why AOD matters⚠️ 2026 Peptide Restrictions: What may change with GLPs and peptides, why prices may rise, and why stocking now could matter🏋️ TRT + Cycle Planning: Deca vs NPP, cutter compounds, growth hormone dosing, and why long-term low-dose HGH wins🧠 Sub-Q vs IM Testosterone: Aromatization, injection frequency, and real-world pros and cons🧬 Bioregulators Explained: How bioregulators differ from peptides, gene signaling vs stimulation, and examples like Epitalon👵 56-Year-Old Longevity Stack: RETA titration, MOTS-C, SS-31, NAD+, inflammation control, and safe fat-loss additions⚖️ Cancer History & Peptides: What to avoid, what’s safer, and how to approach healing without over-stimulation🏃 Athlete Recovery & Energy: Wolverine stack, secretagogues, HGH, and staying mobile past 40🔥 RETA Cycling: How long to run it, tapering vs stopping cold turkey, and when it “works again” after a break🥗 Plateaus After GLP-1/2: Why GLP-3 may be the answer when hunger never shuts off and fat loss stalls🧠 Mental Clarity Stacks: MOTS-C, SS-31, NAD+, C-Lanx, C-Max, and energy for high-output professionals🦠 Chronic UTIs & Sepsis: Thymosin Alpha-1, BPC-157, TB-500, KPV, gut repair, and immune balance🔁 Long-Term Peptide Use: Can you stay on peptides forever, when to cycle, and avoiding diminishing returns💡 Peptides are tools not shortcuts. Stack them with training, protein, sleep, and discipline for results that stick.👉 Drop your questions below for next week’s Q&A.📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results.You’re a warrior. Act like one.

  • Peptide of The Week

    Peptide of the Week: Tesofensine & Methylene Blue – Mood, Focus & Appetite Control

    12/15/2025 | 38 mins.

    Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas explore two powerful compounds that aren’t technically peptides but absolutely belong in the conversation for cognitive enhancement, mood regulation, appetite control, and metabolic support.Whether you’re struggling with cravings, brain fog, or just looking to feel sharper and more in control as you head into 2026 this episode breaks it all down with real-world experience and science-backed discussion.We cover:🧠 Tesofensine The dopamine-driven mood & motivation booster– Triple monoamine reuptake inhibitor (serotonin, dopamine, norepinephrine)– Designed to elevate mood, focus, and contentment without artificial spikes– Powerfully reduces cravings by making the brain feel “satiated”– Used off-label as an antidepressant alternative and appetite suppressant– Known to enhance decision-making and reduce impulsive behaviors⚠️ May not be for everyone JD shares his experience of feeling foggy and unmotivated, while Will thrives on it daily🧪 Methylene Blue The mitochondrial optimizer– Originally developed as a medical dye, now used for brain and blood health– Enhances oxygen transport and mitochondrial efficiency– Boosts NAD and glutathione levels for detox, brain clarity, and energy– Shown to help stabilize emotions, mood, and neuroinflammation– May support cognitive function, memory retention, and aging brain cells💡 Best taken on its own do not stack with Tesofensine or SSRIs due to serotonin overload risk👀 Real Talk:– JD and Will explain the massive differences in personal reactions to both compounds– Why you should treat your body as a science experiment: test, track, and pivot– The surprising link between sugar cravings and reduced sex drive– Why Tesofensine may be a better entry point than GLP-1s for appetite control💊 Dosing Recap:– Tesofensine: Start at 250mcg daily, titrate up to 500–1000mcg if well tolerated– Methylene Blue: Use solo, preferably after cycling off other mood regulators📌 Whether you’re trying to reduce nighttime cravings, sharpen your brain, or protect long-term mental health this duo offers next-gen tools for performance and well-being.💬 Got questions or want us to break down other non-peptide cognitive stacks? Drop a comment below.📺 Subscribe for more deep dives no fluff, just real-world feedback.

  • Peptide of The Week

    Peptide Q&A #19 – Stacking Smart, Cycling Safely, and Real-World Protocols

    12/11/2025 | 56 mins.

    Welcome back, warriors! In this week’s Peptide Q&A, JD Denham and William T. Haas sit down together in their brand-new podcast studio for the very first time. From faith to hard work to peptide science, this episode blends real-life transformation with practical guidance on stacking, cycling, and optimizing results.We cover:🔥 The New Studio Reveal: JD & Will talk about building their own podcast space, sobriety, faith, and the unseen grind behind every success story.💪 Cycling Peptides 101: How long to stay on RETA, AOD, MOTS-C, and TESSA and when to rotate or stack for the best results.⚡ Women’s Protocol Breakdown: Real-world fat-loss stack for a 44-year-old female using RETA, 5-Amino-1-MQ, AOD, MOTS-C, and more what’s too much and what’s working.🧬 Melanotan 1 vs 2: The difference between the two tanning peptides, side effects, and how to avoid the “cherry-red” look.💉 Testosterone Shortage Explained: What’s really happening with TRT vials, how to substitute safely, and why dosing math matters.💊 Heart-Rate Variability & RETA: Why HRV drops on GLP-1s, how to recover faster, and which calming stacks (C-Link, C-Max, Oxytocin) actually work.🏋️ Bulking for Builders: JD’s favorite MK-677 + IGF-1 LR3 combo, with Will’s insights on testosterone thresholds, protein timing, and nutrient partitioning.🧠 Post-Surgery Healing Stack: JD shares the “Wolverine Protocol” that rebuilt his spine recovery BPC-157 + TB-500 dosing for faster healing.🔥 Fat-Loss Tweaks for Athletes: RETA + MOTS-C + AOD + SLU-PP-332 how to shred the last 10 lbs without losing muscle.⚔️ Peripheral Neuropathy Fix: Why BPC + TB + KPV is a must for nerve repair and inflammation control.🙏 Faith, Sobriety, & Gratitude: The promises of hard work, staying sober, and giving God the glory for every win.💡 Peptides are tools not shortcuts. Stack them with training, protein, recovery, and faith for results that last.👉 Drop your questions below for next week’s Q&A.📌 Subscribe for weekly no-fluff education, real-world protocols, and lived experience from JD and Will.You’re a warrior. Act like one.

  • Peptide of The Week

    Peptide of the Week: Peptides 101 – What They Are, How They Work & Why They Matter

    12/08/2025 | 47 mins.

    Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas go back to basics with a no-fluff guide to understanding peptides what they are, how they work, and what every beginner needs to know before starting.Whether you’re completely new to peptides or want a deeper understanding of dosing, safety, and how they differ from hormones and supplements, this episode is your Peptides 101 masterclass.We cover:🧬 What are peptides, really?– Chains of 2–50 amino acids that signal natural processes in the body– How they differ from proteins, hormones, and steroids– Why they enhance your body’s natural functions without shutting anything down🔍 Are peptides safe?– No deaths, no overdoses, no hormonal shutdown– Biggest risk? Buying low-quality peptides from shady sources– The importance of sourcing clean, tested compounds and starting slow⚖️ Peptides vs Hormones– Peptides signal your body to act they don’t replace or override hormones– Hormones like testosterone can suppress natural function peptides support it– Why side effects are minimal, and how to avoid histamine or allergic reactions💉 How to take them & how they work– 4 main methods: injectable, oral, intranasal, transdermal– Which routes are best for which peptides (GHK-Cu, KPV, PT-141, etc.)– Injection tips, handling storage, and why bacteriostatic water matters– Travel tips, reconstitution advice, and how to stay safe while dosing on the go🔥 When peptides actually work best– Why hormone optimization comes first– The real value of dialing in your diet, training, sleep, and lifestyle– How peptides act like rocket fuel but only if your engine is tuned📋 Use Cases & RecommendationsMitochondrial Support & Energy– MOTS-c, SS-31, NAD+, EpitalonInflammation & Gut Health– TA-1, BPC-157, TB-500, KPV, VIP, LL-37Injury Recovery & Pain– Wolverine Stack (BPC-157 + TB-500), Tri-Heal, Glow– Tendons: BPC | Muscles: TB-500 | Skin: GHK-Cu | Gut: KPVFat Loss & Body Composition– AOD-9604, SLUPP-332, Tesamorelin, 5-Amino-1MQ, RetatrutideCognition & Brain Function– Dihexa, CMAX, C-Lank, Semax, PE-22-28Skin, Hair & Anti-Aging– GHK-Cu, Epitalon, NAD+, HGH Secretagogues (Tesa, CJC, IPA)Sleep, Mood & Recovery– Tesamorelin, CJC-1295, PT-141, Oxytocin, GH blends💡 Whether you're brand new to peptides or looking to elevate your current stack this episode gives you the real-world, experience-backed blueprint to understand how these compounds can truly change your life.🧪 This isn’t hype it’s science, experimentation, and years of hands-on testing with clients, coaches, and doctors.💬 Got questions or peptide topics you want broken down? Drop a comment below.📺 Subscribe for more no-fluff, real science weekly.

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About Peptide of The Week

Hosted by JD Denham and Will Haas, The Peptide of The Week Podcastis your no-BS guide to peptides, performance, and total body optimization. Whether you’re an athlete, a high performer, or just hungry to feel better, move better, and live stronger this show’s for you. JD and Will dive deep into real-world protocols, hard-earned lessons, and the science behind what actually works. With expert guests and raw conversations, you’ll get everything from cutting-edge peptide talk to diet, training, recovery, and mindset. No fluff. No filters. Just the tools to rebuild your body and upgrade your life.
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