Over 50 & Flourishing with Dominique Sachse

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In this episode of Over 50 & Flourishing, I sit down with one of the leading minds in longevity science to unpack one of the most talked-about molecules in aging today: NAD.
We’ve all heard the buzz, but what is NAD, and why does it matter so much as we age? From energy and brain function to hormones, skin, and metabolism, this powerful molecule plays a critical role in how our bodies function and declines significantly after our 30s. Dr. Andrew Salzman breaks down the science in a way that actually makes sense, helping us understand what’s really happening inside our cells and how it impacts aging, menopause, and overall vitality.
We also dive into the connection between NAD, inflammation, the microbiome, and cellular energy, and what we can do to better support our bodies as we move through life.
Dr. Andrew Salzman is a Harvard-educated physician and biomedical entrepreneur with more than 30 years of experience in drug discovery. He has published over 170 clinical studies, holds more than 50 patents, and is known for pioneering work in NAD biology, DNA repair, and longevity science. He currently serves as Chief Medical Officer at Wonderfeel, where he focuses on developing science-backed solutions for healthy aging.

Subscribe and save $15 off the one-time price at https://getwonderfeel.com
Custom Promo Code: FLOURISHING
Offer: Customers will receive a travel-size, seven-day Youngr™ NMN pouch with their order
Campaign Duration: April 20–April 27

Keep in Touch:
Website: ⁠⁠⁠⁠⁠⁠⁠https://dominiquesachse.tv/⁠⁠⁠⁠⁠⁠⁠
Book: ⁠⁠⁠⁠⁠⁠⁠https://dominiquesachse.tv/book/
Insta: ⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dominiquesachse/
Facebook: ⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/DominiqueSachse/
TikTok: ⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@dominiquesachse?lang=en
YouTube: ⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@dominiquesachsetv

Have a question for Dominique? Submit it here for a chance to have it answered on the show! https://forms.gle/MpTeWN1oKN8t18pm6

Interested in being featured as a guest? Please email ⁠⁠⁠⁠⁠⁠⁠[email protected]⁠⁠⁠⁠⁠⁠⁠

We want to make the podcast even better. Help us learn how we can: ⁠⁠⁠⁠⁠⁠⁠https://bit.ly/2EcYbu4⁠⁠⁠⁠⁠⁠⁠

Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.

Produced by Dear Media.
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

🎟️ Don’t miss your chance to experience the Behind the Curtain tour LIVE! Grab your tickets now before they’re gone! Get yours here: https://linktr.ee/over50flourishing

In this episode of Over 50 and Flourishing, I sit down with Dr. Maria Sophocles for a conversation about sex, menopause, and the changes that can impact intimacy in midlife.
Dr. Maria Sophocles is a menopause expert, pioneering gynecologist, TED speaker, and passionate advocate for women’s sexual health. Known for her candid, no-shame approach, she’s helping women reclaim their right to pleasure and better understand the physical, emotional, and societal factors that shape intimacy as we age. Her book The Bedroom Gap explores the disconnect between partners’ expectations and experiences, and offers a new framework for improving communication, desire, and connection.
We talk about why so many women feel unprepared for the changes that come with menopause, the truth behind low libido and painful sex, and how hormones, culture, and misinformation have shaped our understanding of intimacy. Dr. Sophocles breaks down the real, practical solutions, from vaginal estrogen and testosterone to simple shifts like scheduling connection and improving communication with your partner.

For more on Dr. Maria, follow her on:
Website: https://mariasophoclesmd.com/
Instagram: https://www.instagram.com/mariasophoclesmd/?hl=en
Watch her TED Talk: https://www.ted.com/speakers/maria_sophocles
Her book, The Bedroom Gap: https://a.co/d/08S80YFo

Thanks to my Sponsors:
Hill House Home: Get 15% off your first order of $100 or more at HillHouseHome.com with code FLOURISHING
O Positiv: Take proactive care of your health and head to OPositiv.com/FLOURISHING or enter FLOURISHING at checkout for 25% off your first purchase
Branch Basics: Get 15% off Branch Basics with the code OVER50 at https://branchbasics.com/OVER50 #branchbasicspod
Leesa: Go to Leesa.com for 20% off PLUS get an extra $50 off with promo code OVER50, exclusive for my listeners
Manukora: Head to MANUKORA.com/FLOURISHING to save up to 31% plus $25 worth of free gifts with the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travelsticks, a wooden spoon, and a guidebook
The Academy of Nutrition and Dietetics: Visit eatright.org/everytable to learn more and find a nutrition and dietetics professional
Gusto: Try Gusto today at gusto.com/OVER50, and get three months free when you run your first payroll. That’s three months of free payroll at gusto.com/OVER50

Keep in Touch:
Website: ⁠⁠⁠⁠⁠⁠⁠https://dominiquesachse.tv/⁠⁠⁠⁠⁠⁠⁠
Book: ⁠⁠⁠⁠⁠⁠⁠https://dominiquesachse.tv/book/
Insta: ⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dominiquesachse/
Facebook: ⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/DominiqueSachse/
TikTok: ⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@dominiquesachse?lang=en
YouTube: ⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@dominiquesachsetv

Have a question for Dominique? Submit it here for a chance to have it answered on the show! https://forms.gle/MpTeWN1oKN8t18pm6

Interested in being featured as a guest? Please email ⁠⁠⁠⁠⁠⁠⁠[email protected]⁠⁠⁠⁠⁠⁠⁠

We want to make the podcast even better. Help us learn how we can: ⁠⁠⁠⁠⁠⁠⁠https://bit.ly/2EcYbu4⁠⁠⁠⁠⁠⁠⁠

Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.

Produced by Dear Media.
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

🎟️ Don’t miss your chance to experience the Behind the Curtain tour LIVE! Grab your tickets now before they’re gone! Get yours here: https://linktr.ee/over50flourishing

In this episode of Over 50 & Flourishing, I’m joined by Courtney for a candid and thoughtful conversation that starts with hair but quickly becomes something much deeper: identity, confidence, and the courage to embrace change. Together, we explore why something as simple as a hairstyle can carry so much meaning, and how many women tie their sense of self to how they look.
From my own experiences with hair transformations to our reflections on fear, judgment, and self-worth, we talk about what it really means to step outside of your comfort zone and redefine beauty on your own terms. We discuss the pressure to stay the same, the freedom that comes with evolving, and how even small changes can spark personal growth. This episode is an honest look at the emotional layers behind change, and a reminder that embracing it can lead you closer to your most authentic and confident self.

Have a question for Dominique? Submit it here for a chance to have it answered on the show! https://forms.gle/MpTeWN1oKN8t18pm6

Thanks to my Sponsors:
Good Ranchers: Get free meat with every order, and $25 off your first order with code OVER50 when you start your plan on GoodRanchers.com
Caraway: Visit Carawayhome.com/OVER or use code OVER at checkout to take an additional 10% off your next purchase.
The Academy of Nutrition & Dietetics: Visit eatright.org/everytable to learn more and find a nutrition and dietetics professional
Honeylove: Save 20% off Honeylove by going to honeylove.com/OVER50 #honeylovepod
Qualia: Go to qualialife.com/FLOURISHING for 50% off and use code FLOURISHING for an additional 15% off your order
Cheers: Take Cheers Restore after your last drink or before going to bed and wake up feeling at least 50% better or your money back. For a limited time my listeners are getting 20% off their entire order at CheersHealth.com/FLOURISHING #Cheers #ad

Keep in Touch:
Website: ⁠⁠⁠⁠⁠⁠⁠https://dominiquesachse.tv/⁠⁠⁠⁠⁠⁠⁠
Book: ⁠⁠⁠⁠⁠⁠⁠https://dominiquesachse.tv/book/
Insta: ⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dominiquesachse/
Facebook: ⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/DominiqueSachse/
TikTok: ⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@dominiquesachse?lang=en
YouTube: ⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@dominiquesachsetv

Interested in being featured as a guest? Please email ⁠⁠⁠⁠⁠⁠⁠[email protected]⁠⁠⁠⁠⁠⁠⁠

We want to make the podcast even better. Help us learn how we can: ⁠⁠⁠⁠⁠⁠⁠https://bit.ly/2EcYbu4⁠⁠⁠⁠⁠⁠⁠

Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.

Produced by Dear Media.
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of Over 50 and Flourishing, I sit down with Gabby Reece for a powerful conversation about identity, resilience, and what it really means to live strong.
Gabby Reece is a former professional beach volleyball player, Nike’s first female signature athlete, and a wellness entrepreneur who has spent decades helping women redefine strength beyond performance. From a childhood marked by instability to building a life rooted in discipline, purpose, and authenticity, Gabby brings both lived experience and hard-earned wisdom to the conversation.
We talk about letting go of guilt and learning to prioritize your own wellbeing, the identity shifts that come with motherhood, and how to maintain a sense of self while raising children. We also explore setting boundaries with family, redefining strength through femininity and emotional awareness, navigating long-term relationships with honesty and respect, and why taking care of yourself first is essential, not selfish.

For more on Gabby, follow her on:
Instagram: https://www.instagram.com/gabbyreece/
Facebook: https://www.facebook.com/OfficialGabrielleReece/
TikTok: https://www.tiktok.com/@gabbyreeceofficial
Watch her podcast, The Gabby Reece Show: https://www.youtube.com/c/gabbyreece
Website: https://gabbyreece.com/

Thanks to my Sponsors:
Hero Bread: Go to hero.co and use code FLOURISHING at checkout for 10% off your order
Hill House Home: Get 15% off your first order of $100 or more at HillHouseHome.com with code FLOURISHING
Ritual: Save 25% on your first month at Ritual.com/OVER50
O Positiv: Head to OPositiv.com/FLOURISHING or enter FLOURISHING at checkout for 25% off your first purchase
Wayfair: Head to Wayfair.com right now to shop all things home
Academy of Nutrition and Dietetics: Visit eatright.org/everytable to learn more and find a nutrition and dietetics professional
Gusto: Try Gusto today at gusto.com/OVER50, and get three months free when you run your first payroll.

Keep in Touch:
Website: ⁠⁠⁠⁠⁠⁠⁠https://dominiquesachse.tv/⁠⁠⁠⁠⁠⁠⁠
Book: ⁠⁠⁠⁠⁠⁠⁠https://dominiquesachse.tv/book/
Insta: ⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dominiquesachse/
Facebook: ⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/DominiqueSachse/
TikTok: ⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@dominiquesachse?lang=en
YouTube: ⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@dominiquesachsetv

Have a question for Dominique? Submit it here for a chance to have it answered on the show! https://forms.gle/MpTeWN1oKN8t18pm6

Interested in being featured as a guest? Please email ⁠⁠⁠⁠⁠⁠⁠[email protected]⁠⁠⁠⁠⁠⁠⁠

We want to make the podcast even better. Help us learn how we can: ⁠⁠⁠⁠⁠⁠⁠https://bit.ly/2EcYbu4⁠⁠⁠⁠⁠⁠⁠

Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.

Produced by Dear Media.
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

🎟️ Don’t miss your chance to experience the Behind the Curtain tour LIVE! Grab your tickets now before they’re gone! Get yours here: https://linktr.ee/over50flourishing

In this episode of Over 50 & Flourishing, I sit down with board-certified plastic and reconstructive surgeon Dr. Terry Dubrow. Many of you may know him from hit TV shows like The Swan and Botched, and today he joined me to discuss the future of aging, from GLP-1 medications and biohacking to the biggest misconceptions about plastic surgery and what actually helps us look and feel our best as we get older.
We dive into everything from facelifts and filler fatigue to why so many procedures go wrong, and what truly makes someone look refreshed rather than overdone. But this conversation goes far beyond aesthetics, we also unpack the explosive role of AI in healthcare, the concept of longevity “escape velocity,” and what it really means to preserve your body so you can take advantage of what’s coming next in medicine.

For more on Dr. Terry Dubrow, follow him on:
Dr. & Mrs. Guinea Pig on YouTube: https://www.youtube.com/@heatherdubrow
Listen to The Between Us Podcast: https://www.instagram.com/betweenusthepodcast/
Instagram: https://www.instagram.com/drdubrow/
Facebook: https://www.facebook.com/DrDubrow

Thanks to my Sponsors:
Save 25% on your first month at Ritual.com/OVER50
Use code OVER50 for 15% off the Premium Starter Kit at BranchBasics.com
Get 10% off your first order sitewide with code FLOURISHING at OSEAMalibu.com
Go to Leesa.com for 20% off mattresses PLUS get an extra $50 off with promo code OVER50, exclusive for my listeners.
Head to Manukora.com/FLOURISHING to save up to 31% plus $25 worth of free gifts with the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travel sticks, a wooden spoon, and a guidebook!
For a limited time, Hollow Socks is having a Buy 2, Get 2 Free Sale. Head to Hollowsocks.com today to check it out. After you purchase, they will ask you where you heard about them. You can support our show and tell them we sent you.
Get $25 off your first order using my exclusive code, OVER50. GoodRanchers.com

Keep in Touch:
Website: ⁠⁠⁠⁠⁠⁠⁠https://dominiquesachse.tv/⁠⁠⁠⁠⁠⁠⁠
Book: ⁠⁠⁠⁠⁠⁠⁠https://dominiquesachse.tv/book/
Insta: ⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dominiquesachse/
Facebook: ⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/DominiqueSachse/
TikTok: ⁠⁠⁠⁠⁠⁠⁠https://www.tiktok.com/@dominiquesachse?lang=en
YouTube: ⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/@dominiquesachsetv

Have a question for Dominique? Submit it here for a chance to have it answered on the show! https://forms.gle/MpTeWN1oKN8t18pm6

Interested in being featured as a guest? Please email ⁠⁠⁠⁠⁠⁠⁠[email protected]⁠⁠⁠⁠⁠⁠⁠

We want to make the podcast even better. Help us learn how we can: ⁠⁠⁠⁠⁠⁠⁠https://bit.ly/2EcYbu4⁠⁠⁠⁠⁠⁠⁠

Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.

Produced by Dear Media
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.