GLP-1 Hub: Support, Community, and Weight Loss

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Most people think of a GLP-1 as a weight loss medication, but for your heart, the story starts before the scale moves much at all. Board-certified cardiologist and lipidologist Dr. Sirisha Vadali explains what the research shows about GLP-1s and cardiovascular risk, the simple routine she starts her patients on, and what she monitors along the way. You'll also hear why she doesn't recommend a GLP-1 for family history alone, and about one genetic cholesterol marker that diet and exercise can't change, a lab she says everyone should have checked once in their lifetime.

**IN THIS EPISODE**

- How GLP-1s went from diabetes drugs to heart protection, with or without diabetes
- Why some heart benefit appears before major weight loss, and why no one knows exactly how yet
- Who GLP-1s are currently indicated for in cardiovascular risk reduction, and why semaglutide (Wegovy) is the one with outcomes data so far
- Why muscle mass, protein, and strength training belong in every GLP-1 plan
- Dr. Vadali's simple phase one: 100 grams of protein (30 to 40 grams in the morning), 25 grams of fiber, water, and strength training twice a week at home
- Watching blood pressure, heart rate, hydration, and kidney function on a GLP-1
- Fatigue and low motivation after the shot: what to rule out first
- Whether family history alone is a reason to start a GLP-1
- The heart labs she checks, including Lp(a), ApoB, hs-CRP, and a coronary calcium score
- What Lp(a) is, why it's a one-time lifetime screening, and the treatments expected in the next few years
- A word of caution on buying unapproved triple agonists online
- Simple longevity habits: sleep, stress, walking after meals, and the 80/20 approach
- Why hunger coming back isn't a reason to panic

**ABOUT THE GUEST**

Dr. Sirisha Vadali, MD, is a board-certified cardiologist and advanced lipidologist specializing in prevention, cardiometabolic medicine, and women's heart health. She is program director for HonorHealth's Cardiometabolic Program in Scottsdale, Arizona, and a member of the HonorHealth Women's Heart Health team. Dr. Vadali focuses on prevention-forward care, using advanced lipid testing, coronary calcium scoring, and lifestyle medicine to help patients lower cardiovascular risk and build sustainable, healthy habits.

**CONNECT WITH DR. SIRISHA VADALI**

Website: https://www.sirishavadali.com
Instagram: https://www.instagram.com/vadalimd/
HonorHealth Cardiometabolic Program: https://www.honorhealth.com/physicians/sirisha-vadali

**SPONSORS**

This episode is brought to you by Timeline. When you buy a one-month supply of Mitopure Gummies, you'll get a free Discovery Size Mitopure Firming Serum, an $85 value. Go to https://www.timeline.com/glp1bundle to claim yours.

This episode is also brought to you by Tyde Wellness, the GLP-1 provider Ana uses, with nutrition guidance built for GLP-1s, independent licensed providers, and a care team that answers when something comes up. Go to https://tydewellness.com/GLP1Hub and use code GLP1Hub50 for $50 off your first month.

**CHAPTERS**

00:00 Preview: why wait for a heart attack?
00:12 What's in this episode
01:07 Welcome, Dr. Sirisha Vadali
02:11 How GLP-1s went from diabetes drugs to heart protection
03:35 How GLP-1s protect the heart, even before weight loss
05:35 Semaglutide vs. tirzepatide: which she uses and why
06:17 What lower obesity rates could mean for heart health
08:44 Lower BMI and high risk: lifestyle first, then a low dose
10:26 Her simple phase one routine and at-home strength training
13:23 Kidneys, hydration, and how often to check blood pressure
14:33 Fatigue and low motivation after the shot
15:59 Sponsor: Timeline
16:53 Is family history a reason to start a GLP-1?
18:31 The heart lab panel she recommends
20:10 New Lp(a) treatments on the way
21:08 What Lp(a) is and why it matters
23:25 A caution on unapproved triple agonists
26:41 Sponsor: Tyde Wellness
27:42 Longevity basics: sleep, stress, walks, and 80/20
30:29 Quick fixes, food noise, and when hunger comes back
32:09 Where to find Dr. Vadali

MORE FROM GLP-1 HUB
📬 Get The Steady State, Ana's weekly newsletter with GLP-1 guidance from a dietitian who's on one: http://join.glp-1hub.com

🎙 Subscribe wherever you listen to podcasts, and if this episode helped, leave a quick review on Apple Podcasts or Spotify - it's the single best way to help more people find the show.

🌐 Shop GLP-1 essentials, meal plans, and recipes: https://shop.glp-1hub.com
📷 Follow on Instagram: @glp1hub
📺 Watch on YouTube: https://www.youtube.com/@GLP-1hub
*Some of the links shared are affiliate links. When you make a purchase, I will receive a small commission at no cost to you. Thank you for supporting the show.
*The content of this show is for informational purposes only and does not constitute medical advice. The goal of this show is to provide various points of view about GLP-1 Medications. The personal and professional opinion of the guests and their content does not necessarily reflect the opinion of Ana Reisdorf or GLP-1 Hub.

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A daily GLP-1 pill sounds like an easy way to maintain your weight loss, but what happens when it doesn't work like the shot did? Registered dietitian Whitney Black, who lives with type 1 diabetes, shares what happened when she switched from Zepbound to Foundayo (orforglipron) for maintenance, and why she went back after two months. You'll hear how her fullness cues, blood sugar, and insulin needs changed, and what she tells clients about weight regain. The surprise wasn't the food noise. It was a different signal that quietly went missing. This is one person's experience, not a verdict on how the pill will work for everyone.

IN THIS EPISODE

- Whitney's path to Zepbound with type 1 diabetes, Hashimoto's, and PCOS
- Why hunger and fullness dysregulation is biology, not a personal failing
- Where GLP-1s stand for type 1 diabetes, and why insulin changes need your care team
- What Foundayo is (an oral GLP-1 from Eli Lilly, not tirzepatide) and how its dosing differs
- How her fullness cues and blood sugar changed on Foundayo, and the roughly 15 pounds she regained in two months
- Cost versus effectiveness when choosing a maintenance option
- Switching back to Zepbound and slowly titrating up again
- Practical and mental strategies when weight comes back after a break in medication

ABOUT THE GUEST

Whitney Black, MBA, MS, RD, LD, LMNT, is a registered dietitian specializing in weight management and practical nutrition for individuals using GLP-1 medications. Through her private practice and online education, she helps people navigate nutrition, weight management, and metabolic health with an evidence-based, realistic approach. Whitney also brings her own lived experience with weight management and GLP-1 medications to her work, allowing her to connect clinical expertise with the real-life experience of navigating these treatments. She is also the author of an upcoming GLP-1-focused cookbook with Fair Winds Press.

CONNECT WITH WHITNEY BLACK

Instagram: https://www.instagram.com/whitney.the.dietitian/
Work with Whitney (Nourish): https://signup.nourish.com/providers/whitney-black

SPONSORS

This episode is brought to you by Timeline. When you buy a one-month supply of Mitopure Gummies, you'll get a free Discovery Size Mitopure Firming Serum, an $85 value. Go to https://www.timeline.com/glp1bundle to claim yours.

This episode is also brought to you by Tyde Wellness, the GLP-1 provider Ana uses, with nutrition guidance built for GLP-1s, independent licensed providers, and a care team that answers when something comes up. Go to https://tydewellness.com/GLP1Hub and use code GLP1Hub50 for $50 off your first month.

CHAPTERS

00:00 Preview: why the pill appealed to her
00:21 Introduction
01:04 Welcome, Whitney Black
02:17 Life before GLP-1s with type 1 diabetes, Hashimoto's, and PCOS
04:54 Starting Zepbound as a dietitian
06:53 Fullness cues: it's biology, not willpower
08:38 GLP-1s and type 1 diabetes today
12:29 Maintenance, dosing, and why she tried Foundayo
12:57 What Foundayo is (and isn't)
14:29 Sponsor: Timeline
15:23 Foundayo dosing and the first weeks
16:44 Losing the fullness signal
18:53 Rising blood sugar and insulin resistance
19:26 Cost versus effectiveness
21:40 Back on Zepbound
24:00 Advice when weight comes back after a break
26:14 Sponsor: Tyde Wellness
27:14 Why it's not just an appetite suppressant
30:08 Where to find Whitney
31:26 Closing

MORE FROM GLP-1 HUB
📬 Get The Steady State, Ana's weekly newsletter with GLP-1 guidance from a dietitian who's on one: http://join.glp-1hub.com

🎙 Subscribe wherever you listen to podcasts, and if this episode helped, leave a quick review on Apple Podcasts or Spotify - it's the single best way to help more people find the show.

🌐 Shop GLP-1 essentials, meal plans, and recipes: https://shop.glp-1hub.com
📷 Follow on Instagram: @glp1hub
📺 Watch on YouTube: https://www.youtube.com/@GLP-1hub
*Some of the links shared are affiliate links. When you make a purchase, I will receive a small commission at no cost to you. Thank you for supporting the show.
*The content of this show is for informational purposes only and does not constitute medical advice. The goal of this show is to provide various points of view about GLP-1 Medications. The personal and professional opinion of the guests and their content does not necessarily reflect the opinion of Ana Reisdorf or GLP-1 Hub.

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If you're taking a GLP-1, headlines about sudden vision loss can leave you wondering whether the medication helping you lose weight is putting your eyesight at risk. Ana Reisdorf talks with Dr. Luke Sorrell about NAION, a rare optic nerve condition, and the semaglutide research behind those headlines. You'll learn how to put "double the risk" into perspective, what questions to bring to your doctor, and why your health history matters to the conversation.

**IN THIS EPISODE**

- What NAION is and how it can affect vision
- What semaglutide studies suggest, and the limits of observational research
- Why relative risk and absolute risk tell different parts of the story
- How diabetes, sleep apnea, cardiovascular health, and optic nerve anatomy fit into the discussion
- Blood pressure changes, dehydration, and rapid blood sugar changes as possible contributing factors
- Questions to ask your prescriber and eye care professional about your individual risk
- What remains uncertain about tirzepatide and other GLP-1 medications
- Weighing potential eye risks alongside the benefits of GLP-1 treatment

**ABOUT THE GUEST**

Dr. Luke Sorrell is a board-certified internal medicine physician, Fellow of the American College of Physicians, and founder of Sorrell MD, a concierge longevity and precision telemedicine practice based in Dallas-Fort Worth, Texas, serving patients across the U.S. He trained at UT Houston McGovern Medical School and completed his residency at Baylor University Medical Center in Dallas. His career has spanned hospital medicine, primary care, and longevity medicine. Today, he works with high-performing and health-conscious individuals across the country, using tools like cardiac CT angiography, VO2 max and metabolic testing, DEXA, genomics, and advanced hormone and lipid panels to identify health risks earlier. He also advises health tech companies building the next generation of care.

**CONNECT WITH DR. LUKE SORRELL**

Website: https://www.sorrell-md.com
LinkedIn: https://www.linkedin.com/in/luke-sorrell-md/
Instagram: https://www.instagram.com/sorrellmd/
Facebook: https://www.facebook.com/SorrellMD
Substack: https://substack.com/@sorrellmd

**SPONSOR**

Tyde Wellness offers GLP-1 care with licensed providers, nutrition guidance, and ongoing support. Use code GLP1Hub50 for $50 off your first month.
https://tydewellness.com/GLP1Hub

**CHAPTERS**

00:00 GLP-1s and NAION: The "double risk" headline
01:42 Meet Dr. Luke Sorrell
02:52 What is NAION?
05:10 How rare is NAION?
06:13 Diabetes, sleep apnea, and other risk factors
07:50 What the studies show and their limitations
10:49 Relative risk versus absolute risk
11:58 Sponsor: Tyde Wellness
13:22 Semaglutide, tirzepatide, and unanswered questions
14:22 Possible mechanisms: Blood pressure, oxygen, and hydration
19:05 Eye exams, optic nerve anatomy, and rapid A1C changes
22:15 Questions to bring to your doctor
24:54 Ana's Plateau Breakthrough Playbook
26:15 Staying grounded when health headlines spread
27:20 Retatrutide and the future of GLP-1 treatment
29:31 Connect with Dr. Sorrell
30:01 Weighing eye concerns against cardiovascular benefits
31:25 Closing thoughts and podcast reviews

MORE FROM GLP-1 HUB
📬 Get The Steady State, Ana's weekly newsletter with GLP-1 guidance from a dietitian who's on one: http://join.glp-1hub.com

🎙 Subscribe wherever you listen to podcasts, and if this episode helped, leave a quick review on Apple Podcasts or Spotify - it's the single best way to help more people find the show.

🌐 Shop GLP-1 essentials, meal plans, and recipes: https://shop.glp-1hub.com
📷 Follow on Instagram: @glp1hub
📺 Watch on YouTube: https://www.youtube.com/@GLP-1hub
*Some of the links shared are affiliate links. When you make a purchase, I will receive a small commission at no cost to you. Thank you for supporting the show.
*The content of this show is for informational purposes only and does not constitute medical advice. The goal of this show is to provide various points of view about GLP-1 Medications. The personal and professional opinion of the guests and their content does not necessarily reflect the opinion of Ana Reisdorf or GLP-1 Hub.

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If breast cancer runs in your family, you may be wondering whether you're getting the right screening and what else you can do to lower your risk. Ana Reisdorf talks with Dr. Anne Peled about how GLP-1s may shift the balance, what everyday habits you should build, and why weight can become harder to manage during and after treatment. You'll learn which questions to bring to your care team, how to protect your nutrition, and what emerging GLP-1 research still hasn't answered.

**IN THIS EPISODE**

- How family history and breast density can shape your screening conversation
- Exercise, alcohol, and food choices in the discussion about lowering breast cancer risk
- Why weight, inflammation, and cancer risk are more complicated than a single cause
- What early GLP-1 research suggests, and why prevention questions remain unanswered
- Why hormone-blocking medications and other cancer treatments can affect weight
- Protecting protein and nutrient intake while coordinating weight management with cancer care
- Personalized treatment, emerging research, and advocating for yourself

**ABOUT THE GUEST**

Dr. Anne Peled is a breast cancer and reconstructive surgeon in San Francisco and a two-time breast cancer survivor. She earned her medical degree at Harvard Medical School and completed plastic and reconstructive surgery training and a breast surgical oncology fellowship at UCSF. She is co-director of the Breast Care Center of Excellence at Sutter Health California Pacific Medical Center. Her work focuses on improving breast surgery and reconstruction outcomes, and she brings both a surgeon's and a patient's perspective to care.

**CONNECT WITH DR. ANNE PELED**

Website: https://www.annepeledmd.com
Instagram: https://www.instagram.com/drannepeled/

**SPONSOR**

Tyde Wellness offers GLP-1 care with licensed providers, nutrition guidance, and ongoing support. Use code GLP1Hub50 for $50 off your first month.
https://tydewellness.com/GLP1Hub

**CHAPTERS**

00:00 Body fat, estrogen, and breast cancer risk
00:24 Ana's personal connection and the questions this episode explores
01:33 Meet Dr. Anne Peled
03:29 Early detection, family history, and breast density
05:59 Mammograms and questions about additional scans
07:33 Exercise, alcohol, and nutrition
10:05 Weight, inflammation, and emerging GLP-1 research
11:18 GLP-1s for prevention: What we still don't know
13:39 Sponsor: Tyde Wellness
15:05 GLP-1 cancer concerns and unanswered questions
16:30 Why breast cancer treatment can affect weight
18:58 Discussing GLP-1 treatment with your care team
20:12 Protecting nutrition during cancer treatment
22:53 Survivorship and personalized treatment
25:12 Emerging microbiome research
26:44 Beyond the Shot guide
27:46 Genetics and the future of personalized screening
31:03 Self-advocacy, second opinions, and everyday movement
32:46 Connect with Dr. Peled

MORE FROM GLP-1 HUB
📬 Get The Steady State, Ana's weekly newsletter with GLP-1 guidance from a dietitian who's on one: http://join.glp-1hub.com

🎙 Subscribe wherever you listen to podcasts, and if this episode helped, leave a quick review on Apple Podcasts or Spotify - it's the single best way to help more people find the show.

🌐 Shop GLP-1 essentials, meal plans, and recipes: https://shop.glp-1hub.com
📷 Follow on Instagram: @glp1hub
📺 Watch on YouTube: https://www.youtube.com/@GLP-1hub
*Some of the links shared are affiliate links. When you make a purchase, I will receive a small commission at no cost to you. Thank you for supporting the show.
*The content of this show is for informational purposes only and does not constitute medical advice. The goal of this show is to provide various points of view about GLP-1 Medications. The personal and professional opinion of the guests and their content does not necessarily reflect the opinion of Ana Reisdorf or GLP-1 Hub.

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How are GLP-1 type medications and weight control changing the landscape of heart health? If you're using a GLP-1 for weight or blood sugar, which habits and risk factors still deserve attention? Ana Reisdorf talks with Dr. Melanie Icard about stress, sleep, muscle, food choices, and questions to bring to your healthcare team when heart disease runs in the family.

Dr. Icard shares how her experience with prediabetes shaped her practice and why she asks patients, "What are you doing to relax?" Ana brings the GLP-1 user's perspective: how to eat well with a smaller appetite and make strength work realistic when life is already full. They also discuss what Ana's family history has prompted her to ask about lab markers and heart imaging.

**IN THIS EPISODE**

- Why stress and sleep belong in a conversation about heart and metabolic health
- What it can look like to make room for real rest during a busy week
- How strength work and everyday movement fit into GLP-1 weight loss
- Choosing nourishing meals when your appetite is smaller
- Questions to ask your clinician about family history, lab markers, and heart imaging
- Building habits you can keep up as your health goals change

**ABOUT THE GUEST**

Dr. Melanie Icard, NMD, is a naturopathic and regenerative medicine physician with 24 years of clinical experience, including 11 years in hospital medicine. She leads Dr. Mel Holistic, a cardiovascular and metabolic medicine practice in Scottsdale and Sedona, Arizona, with a national virtual practice. Her Biohacked Heart Blueprint™ examines how chronic stress and HPA axis dysregulation (changes in the body's stress response) may relate to cardiovascular and metabolic health. She teaches the framework to medical professionals nationally.

**CONNECT WITH DR. MELANIE ICARD**

Website: https://www.drmelanieicard.com/
Instagram: https://www.instagram.com/drmelholistic/
YouTube: https://www.youtube.com/@Itsdrmel

**SPONSORS**

Tyde Wellness offers GLP-1 care with licensed providers, nutrition guidance, and ongoing support. Use code GLP1Hub50 for $50 off your first month.
https://tydewellness.com/GLP1Hub

**CHAPTERS**

00:00 What are you doing to relax?
00:18 Ana's family history and heart health beyond the scale
01:11 Meet Dr. Melanie Icard
06:23 Family history, calcium scoring, and prevention
07:09 Stress and sleep in the heart health conversation
08:44 Heart imaging and risk questions
12:58 Finding time to truly relax
15:42 Sponsor: Tyde Wellness
17:19 Stress, blood sugar, and GLP-1 goals
20:41 Meal habits and nutrient dense choices
23:54 Lab markers, imaging, and family risk
26:53 GLP-1s and preserving muscle
28:09 Making relaxation realistic
29:23 Beyond the Shot guide
30:24 Workload, boundaries, and healthy habits
32:10 Who Dr. Icard works with
33:42 Connect with Dr. Icard

MORE FROM GLP-1 HUB
📬 Get The Steady State, Ana's weekly newsletter with GLP-1 guidance from a dietitian who's on one: http://join.glp-1hub.com

🎙 Subscribe wherever you listen to podcasts, and if this episode helped, leave a quick review on Apple Podcasts or Spotify - it's the single best way to help more people find the show.

🌐 Shop GLP-1 essentials, meal plans, and recipes: https://shop.glp-1hub.com
📷 Follow on Instagram: @glp1hub
📺 Watch on YouTube: https://www.youtube.com/@GLP-1hub
*Some of the links shared are affiliate links. When you make a purchase, I will receive a small commission at no cost to you. Thank you for supporting the show.
*The content of this show is for informational purposes only and does not constitute medical advice. The goal of this show is to provide various points of view about GLP-1 Medications. The personal and professional opinion of the guests and their content does not necessarily reflect the opinion of Ana Reisdorf or GLP-1 Hub.