The Dr. Leaf Show

NAD is the molecule in every cell that powers your energy — and there's a kind of exhaustion, the kind a good night's sleep and a weekend off can't fix, that comes from running low on it. If you're a woman in your 40s, 50s, or 60s caring for aging parents while raising kids and running a career — the sandwich generation — that depletion is real, and it's happening at the cellular level.

In this episode, Dr. Caroline Leaf sits down with Mona Rosene, MS, RD, Global Director of Scientific Affairs at Niagen Bioscience, to explore NAD — the coenzyme that powers your mitochondria and fuels over 500 metabolic processes. NAD drops roughly 65% between the ages of 30 and 70, and chronic stress, menopause, poor sleep, and illness deplete it even faster. Mona explains what that means for your energy, brain fog, hormones, and inflammation — and what you can actually do about it.

🔬 What you'll learn:

- Why caregiver exhaustion isn't fixed by sleep — and what's actually being depleted inside your cells

- What NAD+ is, why it powers your mitochondria, and how it fuels over 500 metabolic processes in the body

- How perimenopause, menopause, chronic stress, and aging compound to drain your cellular energy

- Why an unmanaged mind "batters the brain and body" and burns through your NAD+ reserves

- The lifestyle-first approach to rebuilding energy — and when supplementation actually makes sense

- The connection between NAD+, inflammation, PCOS, brain fog, and hormonal health

📚 Resources:

🔗 Tru Niagen (use code DRLEAF20 for 20% off): https://www.truniagen.com

🔗 Guest: Mona Rosene, Niagen Bioscience

🔗 Dr. Leaf's Website: https://drleaf.com

🔗 1:1 Coaching with Dr. Leaf: https://drleaf.com/coaching-1-1

🔗 Neurocycle App: https://theswitch.app

Sponsors helping make this show possible:

• Shopify: Sign up for your one-dollar-per-month trial today at Shopify.com/leaf

• OSEA: Get a spring-worthy glow with clean, clinically tested skincare from OSEA. And right now we have a special discount just for our listeners. Get 10% off your first order sitewide with code LEAF at OSEAMalibu.com

• Air Doctor: Head to AirDoctorPro.com and use promo code DRLEAF to get UP TO $300 off today!

• Veracity Health: So make the switch to GLP-1s the natural way. Head to VeracityHealth.co and use code DRLEAF for up to 60% off your order.

• BetterHelp: Find support and feel lighter in therapy. Sign up and get 10% off at BetterHelp.com/drleaf.

• HelloFresh: Go to HelloFresh.com/drleaf10fm to get 10 free meals plus a FREE Zwilling Knife — a $144.99 value — on your third box. Offer valid while supplies last. Free meals applied as discount on first box, new subscribers only, varies by plan.

🔔 Subscribe so you don't miss the next one — new episodes every Wednesday.

💬 Have you felt the kind of exhaustion that sleep can't fix? Tell me in the comments.

Pick My Brain is Dr. Caroline Leaf's new Q&A series — you send the questions, she answers them with real neuroscience. No fluff, no generic advice. Just honest answers to the things you're actually dealing with.

This week's theme: why adult friendships are dying — and what's happening in your brain when they do.

You have 500 followers and no one to call at 2 AM. The number of Americans with no close friends has quadrupled since 1990. The U.S. Surgeon General has declared loneliness a public health crisis — one that increases your risk of premature death by more than 60%. And yet no one talks about it honestly.

In this episode, Dr. Leaf takes real listener questions on the loneliness epidemic: why friend breakups hurt worse than divorce, why your husband's silence might literally be killing him, what happens in your brain when a friendship turns toxic, and whether it's actually possible to make real friends after 40.

🔬 What you'll learn:

Why a "like" doesn't trigger the same oxytocin response as eye contact — and what your brain actually needs

The neuroscience of friend grief: why losing a friendship activates the same pain centers as physical injury

Why male loneliness is now a public health crisis — and what's happening neurologically when men stop maintaining friendships

How toxic friendships create the same addiction loop as substances — and why leaving one feels like withdrawal

The 9-week rule for rebuilding friendship circuitry in your brain and nervous system

Why jealousy of a friend's success is data, not a character flaw

The science-backed path to making friends after 40 — even when everyone already seems to "have their people"

Resources mentioned: 

Dr. Leaf's Website: https://drleaf.com 

1:1 Coaching: https://drleaf.com/coaching-1-1 

21 Day Brain Detox Course: https://drleaf.com/courses 

Neurocycle App: https://theswitch.app

Sponsors helping make this show possible:

• Shopify: Sign up for your one-dollar-per-month trial today at Shopify.com/leaf

• OSEA: Get a spring-worthy glow with clean, clinically tested skincare from OSEA. And right now we have a special discount just for our listeners. Get 10% off your first order sitewide with code LEAF at OSEAMalibu.com

• Air Doctor: Head to AirDoctorPro.com and use promo code DRLEAF to get UP TO $300 off today!

• Veracity Health: So make the switch to GLP-1s the natural way. Head to VeracityHealth.co and use code DRLEAF for up to 60% off your order.

• BetterHelp: Find support and feel lighter in therapy. Sign up and get 10% off at BetterHelp.com/drleaf.

• HelloFresh: Go to HelloFresh.com/drleaf10fm to get 10 free meals plus a FREE Zwilling Knife — a $144.99 value — on your third box. Offer valid while supplies last. Free meals applied as discount on first box, new subscribers only, varies by plan.

🔔 New episodes every Wednesday. 💬 Got a question for the next Pick My Brain? Drop it in the comments.

Most people would rather shock themselves than sit alone with their own thoughts. In a University of Virginia study, 67% of participants chose physical pain over 15 minutes of silence. That's not a personality flaw — it's a skill most of us were never taught.

In this episode, Dr. Caroline Leaf explains why solitude isn't a luxury or a wellness trend — it's a neurological requirement your brain depends on to function. Drawing on neuroscience, she breaks down what happens when you fill every quiet moment with podcasts, notifications, and noise, and what you're actually losing when you do.

You'll learn the difference between chosen solitude and forced isolation, how the brain's default mode network drives creativity, memory, and emotional regulation — and why shutting it down constantly has real cognitive consequences. You'll also get a simple 15-minute practice to start rebuilding the capacity right now.

If you struggle to be alone with yourself — or you've never thought about it — this episode will change how you think about silence.

Resources mentioned: 

Dr. Leaf's Website: https://drleaf.com 

1:1 Coaching: https://drleaf.com/coaching-1-1 

21 Day Brain Detox Course: https://drleaf.com/courses 

Neurocycle App: https://theswitch.app

Sponsors helping make this show possible:

• Shopify: Sign up for your one-dollar-per-month trial today at Shopify.com/leaf

• OSEA: Get a spring-worthy glow with clean, clinically tested skincare from OSEA. And right now we have a special discount just for our listeners. Get 10% off your first order sitewide with code LEAF at OSEAMalibu.com

• Air Doctor: Head to AirDoctorPro.com and use promo code DRLEAF to get UP TO $300 off today!

• Veracity Health: So make the switch to GLP-1s the natural way. Head to VeracityHealth.co and use code DRLEAF for up to 60% off your order.

• BetterHelp: Find support and feel lighter in therapy. Sign up and get 10% off at BetterHelp.com/drleaf.

• HelloFresh: Go to HelloFresh.com/drleaf10fm to get 10 free meals plus a FREE Zwilling Knife — a $144.99 value — on your third box. Offer valid while supplies last. Free meals applied as discount on first box, new subscribers only, varies by plan.

Tracking apps promise peace of mind — but the neuroscience tells a different story.

About half of U.S. parents now use location-tracking apps like Life360, Find My, and Google Family Link to monitor their kids. A 2024 study found that frequent checking correlates with lower self-esteem in teens and higher parental hostility into the college years. The safety you're buying may be costing you more than you know.

In this episode, neuroscientist Dr. Caroline Leaf breaks down the hidden neuroscience of family surveillance: why every "just checking" reinforces hypervigilance, how tracking apps hijack the same reward circuits as slot machines, and how to rebuild trust without abandoning safety.

You'll learn why your brain reads constant location monitoring as a low-level emergency, how "I just want to know they're safe" gradually trains your nervous system to equate vigilance with love — and why that erodes trust in both directions. Dr. Leaf unpacks the four myths that make surveillance feel like care, and walks through her 5-step Trust Neurocycle: a practical tool to break the checking loop and move from monitoring to mentorship.

Resources mentioned: 

Dr. Leaf's Website: https://drleaf.com 

1:1 Coaching: https://drleaf.com/coaching-1-1 

21 Day Brain Detox Course: https://drleaf.com/courses 

Neurocycle App: https://theswitch.app

Sponsors helping make this show possible:

Shopify: Sign up for your one-dollar-per-month trial today at Shopify.com/leaf

OSEA: Get a spring-worthy glow with clean, clinically tested skincare from OSEA. And right now we have a special discount just for our listeners. Get 10% off your first order sitewide with code LEAF at OSEAMalibu.com

Air Doctor: Head to AirDoctorPro.com and use promo code DRLEAF to get UP TO $300 off today!

Veracity Health: So make the switch to GLP-1s the natural way. Head to VeracityHealth.co and use code DRLEAF for up to 60% off your order.

BetterHelp: Find support and feel lighter in therapy. Sign up and get 10% off at BetterHelp.com/drleaf.

HelloFresh: Go to HelloFresh.com/drleaf10fm to get 10 free meals plus a FREE Zwilling Knife — a $144.99 value — on your third box. Offer valid while supplies last. Free meals applied as discount on first box, new subscribers only, varies by plan.

What if prayer isn’t just spiritual—but neurological?

In this powerful conversation, Dr. Caroline Leaf sits down with Craig Groeschel—founder of Life.Church and New York Times bestselling author—to explore the science of prayer, the reality of burnout, and the mental health crisis many leaders quietly face.

Craig opens up about the moment anxiety hit him like a “40-pound weight” on his chest—and why, after decades of resilience, he suddenly found himself depleted, not just tired. Together, they unpack what neuroscience now confirms: prayer can calm the brain, strengthen emotional regulation, and rewire how we respond to stress.

This episode challenges the idea that faith and mental health are separate—and offers a new framework for understanding prayer not as something you do, but as a state of ongoing awareness that transforms your mind.

You’ll learn:

How prayer impacts the brain, including the prefrontal cortex and amygdala

Why “praying without ceasing” is about awareness, not constant words

The critical difference between being tired and being truly depleted

Why rest alone doesn’t fix burnout—and what actually does

How identity becomes fragile when it’s built on performance

Why doing something uncomfortable or new can reset your nervous system

This is a conversation about faith, science, identity, and what it really takes to heal your mind.

Get Craig's new book, Heal Your Hurting Mind, here: https://www.craiggroeschel.com/books/heal-your-hurting-mind

📚 Resources:

🔗 Dr. Leaf's Website: https://drleaf.com

🔗 1:1 Coaching with Dr. Leaf: https://drleaf.com/coaching-1-1

🔗 Help in a Hurry Course: https://drleaf.com/courses

🔗 Neurocycle App: https://theswitch.app

🔔 Subscribe so you don't miss the next one — new episodes every Wednesday.

Sponsors making this show possible:

BETTERHELP: Find support and feel lighter in therapy. Sign up and get 10% off at BetterHelp.com/drleaf.

SHOPIFY: Sign up for your one-dollar-per-month trial today at Shopify.com/leaf

BROOKLYN BEDDING: Get 30% OFF with code DRLEAF at Brooklynbedding.com

VERACITY: So make the switch to GLP-1s the natural way. Head to VeracityHealth.co and use code DRLEAF for up to 60% off your order.

HELLOFRESH: Go to HelloFresh.com/drleaf10fm to get 10 free meals plus a FREE Zwilling Knife — a $144.99 value — on your third box. Offer valid while supplies last. Free meals applied as discount on first box, new subscribers only, varies by plan.