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Core Memory

Ashlee Vance
Core Memory
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  • The New Era of Consumer DNA Tests
    This week’s guest is Kian Sadeghi, the founder and CEO of Nucleus. Sadeghi has everything you want in a controversialish bio-tech CEO. He’s a college dropout, a Thiel Fellow and a “wild child,” as one Nucleus investor told me. He’s also trying to uplevel the consumer DNA testing game by poring over entire human genomes with every test instead of just looking at snippets of DNA as companies like 23andMe and Ancestry have done for many years.Nucleus charges about $500 for its mainstream health test aimed at adults. It promises to give you insights about a wide variety of health conditions, including your likely disposition toward things like mental health issues, cancers and rare genetic diseases. You can use the information to inform your lifestyle choices and to compare your DNA traits with those of your potential baby making partner to see if you’re a good baby making fit. (You can go here to see how Sadeghi uses this information on dates.)The company also has a new, far more expensive service ($5,000) aimed at parents going through the IVF process to help them select embryos with certain traits. This type of service is quickly becoming all the rage, as we noted in our recent video on Orchid, which you should absolutely watch because it’s awesome. (Orchid contends that it does a much deeper dive on the embryo DNA than does Nucleus. I gave Sadeghi a chance to respond to some of this in the podcast.)Sadeghi has been controversialish because he’s made big claims about Nucleus’s ability to discern things like someone’s IQ from DNA and because he’s been an aggressive marketer in a bio-tech field that tends more toward conservatism - lest one become the next jailed blood testing start-up CEO. He’s also been way more outspoken about the rather obvious direction we’re heading toward where people will be picking the desired traits of their future kids and where sex may well just become a purely recreational event as society moves toward IVF and artificial wombs for the majority of its new human production.What’s clear enough is that the first wave of consumer genetic testing companies arrived many years ago when DNA tests were rarer and more expensive, and we’re now seeing them be usurped by a new crop of services that really take advantage of the massive decreases in sequencing costs. In short, we can test more of your DNA more cheaply than ever before, and we have much better data and software to analyze the DNA now.Sadeghi and I get into all of this on the podcast.The show was made possible by the fine people at E1 Ventures. No cap table is complete without E1, or at least that’s what I tell my kids.Enjoy! This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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  • An AI Engineer Is Here, and It Might Redesign the Physical World
    The news here is that Paul Eremenko has a new start-up called P-1 AI.Eremenko is billing P-1 as one of the first stabs at building an AI engineer. The company’s “Archie” AI can help with day-to-day engineering tasks today, and, if all goes according to plan, will be designing buildings, planes and rockets in the future. We, of course, getting into what Archie can do today and what it might do in the years to come in the pod. Spoiler alert: Eremenko thinks we get MUCH better spaceships. Most of our time, though, was spent discussing Eremenko’s rather incredible life and career.Born in Ukraine, Eremenko came to the US at 11 and went on to get aeronautics degrees from MIT and Caltech and then – just to show off - a law degree from Georgetown. He’s worked at DARPA and Google and as CTO of both Airbus and United Technologies. He also tried to turn hydrogen into a mainstream fuel source for commercial planes at Universal Hydrogen, although that venture did not pan out.And so, we got into Eremenko’s life, aerospace and where AI is possibly taking us a species.Eremenko’s dog Li made a special guest appearance and picked me as his favorite podcast host by the end of the show.As ever, we thank the wonderful people at E1 Ventures for their support with the podcastEnjoy! This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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  • The Future of Money
    More than a decade ago, someone I respect told me to go meet these young, Irish brothers - Patrick and John Collison. The brothers had started a small company called Stripe, and my friend assured me they were primed to accomplish big things. The Collisons were working on payments, and I had no interest in payments, so my attention waned a bit as they described how Stripe functioned and what it would one day do. What was very clear, though, was that the brothers were bright - as in exceptionally bright - and focused and determined. I interview start-up founders for a living, and there’s been a handful of times where I knew for certain that the people in front of me would succeed at whatever they chose to do. This was one of those times. This is a long way of saying that I have the utmost respect for the Collisons and try to take particular note when they and/or Stripe make big bets. They tend to have a pretty accurate window into the future. Last year, Stripe bought Bridge for $1.1 billion. Bridge was a two-year-old start-up that had started out doing some NFT nonsense and then pivoted almost right away into stablecoins. Going off the premise that the Collisons must have spent $1 billion on a very, very, very young company for a reason, we asked Bridge CEO Zach Abrams to come on the podcast to explain what Bridge does, what the hell stablecoins are and where the future of money is heading. Abrams, thankfully, did not disappoint. The short of it is that Bridge has made it much easier for companies and governments to move money internationally. SpaceX, for example, relies on Bridge to collect and process payments for its Starlink internet service in far off lands. The same goes for people sending and receiving remittances, which happens to be a massive part of our global economy. We discuss all this in the show and then get weird. Abrams talks about AIs using credit cards to accomplish tasks out in the world and a future where an AI might end up as the wealthiest being on the planet and what that could mean for us humans and the economy. This podcast was made possible with support from the fine people at E1 Ventures. Enjoy! This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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  • Exclusive: Palmer Luckey and Meta Make Peace to Make War Together
    Palmer Luckey has come on the Core Memory podcast today to deliver some full-on shocking news. (And top tips on raising children as well.)As you’ll hear on the show, Luckey’s company Anduril has partnered with Meta to create a product for the U.S. military dubbed “Eagle Eye.” At its core, this product is meant to become the sci-fi style military helmet that you see depicted in movies but that does not actually exist in real life. It will have displays that place all kinds of information in front of soldiers’ faces by tapping into virtual and augmented reality technology and data feeds that will be pumped into the device.Microsoft once owned the contract to make this type of product for the U.S. Army but had been struggling terribly to deliver anything useful. Anduril took over the $22 billion project earlier this year and will now pair its defense and tech expertise with Meta’s headset and VR/AR expertise to try and give the Army what it desires and modernize the U.S. military in the process. We go into “Eagle Eye,” the technology behind it and how and where it will be made in gory detail on the podcast.This is all shocking for a bunch of reasons, but the lead shocker is that Luckey has agreed to work with Meta and Zuck at all.Some context.In 2014, Facebook acquired Luckey’s Oculus VR for $2 billion. In 2016, Facebook then fired Luckey more or less for being a Republican in public.In the runup to the 2016 election, Luckey gave $9,000 to a group that put up a billboard depicting Hillary Clinton’s face – with an extra-large forehead – and the words “Too Big To Jail” underneath the face. This was during the Clinton e-mail controversy and came at a time when much of Silicon Valley had gone apoplectic about the idea of Donald Trump possibly becoming president.Once the mainstream press figured out that Luckey had paid for the billboard, it went full hysteria mode and portrayed Luckey as some kind of hate-filled, fascist meme lord set on destroying the moral fabric of, er, politics and possibly the American Way of Life. Facebook decided it could not stomach the PR hit and pushed Luckey out of the company. Lawsuits and much vitriol between the two parties followed.For Luckey, the whole incident was well beyond personal. Oculus and VR tech had been his life. Facebook stripped him of his true love, and the press and others turned Luckey into a pariah. The saga is captured wonderfully in Blake Harris’s The History of the Future where hindsight allows us to see how something relatively trivial – the billboard – morphed into an absurdist drama acted out by reporters and Facebook executives.Luckey also made his feelings on the incident very clear in this historic performance in which he eviscerated professional remora Jason Calacanis.But, you know, times change. Zuck and others in Silicon Valley have discovered their inner patriots and want to work on defense tech now. Luckey being buddies with Trump and Republicans is so okay that he can appear in a Meta press release. Public apologies have been made. And now, perhaps, soldiers can have their fancy helmets.We spent two hours chatting with Luckey, and the Anduril/Meta deal is only a fraction of the discussion that also gets into Anduril’s manufacturing expansion, China (of course), AI and a host of other topics.For more Core Memory pods, head here. The episode was made possible by support from E1 Ventures.Enjoy! This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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  • Peter Beck on Rockets, Dinner with Elon and the Future of Space
    The facts are these: Peter Beck is the founder and CEO of Rocket Lab, and Rocket Lab is an absolute beast in the aerospace world. It has launched more than 60 times from spaceports in New Zealand and the US and is in the midst of creating a bigger, more powerful rocket to help it earn more business and compete more directly against SpaceX and others.Beck and Rocket Lab also happen to be near and dear to my heart. I wrote a book about them and made a movie about them.Beck has an incredible life story. He’s a self-taught rocket engineer who built a commercial space giant in New Zealand. None of this should really be possible. You’re supposed to have a PhD in aerospace and/or billions of dollars to be successful in the rocket game, and you’re supposed to build rockets in places that have some experience building rockets. Nonetheless, here we are. Rocket Lab sits alongside SpaceX as the obvious winners to date in the commercial rocket and commercial space games.We’re thrilled that Beck gave us some time as he crunches away on preparing the Neutron rocket for its first launch.This episode was made possible by the fine people at E1 Ventures. We thank them for their support.Enjoy!For more podcasts and the finest in sci-tech reporting, subscribe here. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe
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About Core Memory

Core Memory is a podcast about science and technology hosted by best-selling author and filmmaker Ashlee Vance. Vance has spent the past two decades chronicling advances in science and tech for publications like The Economist, The New York Times and Bloomberg Businessweek. Along with the stories, he's written best-selling books like Elon Musk’s biography, made an Emmy-nominated tech TV show watched by millions and produced films for HBO and Netflix. The goal has always been to bring the tales of complex technology and compelling people to the public and give them a path into exceptional and unusual worlds they would not normally have a chance to experience. www.corememory.com
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