Core Memory

Treating cancer remains a crude practice. We cut, burn and poison tumors, and we do all this with relatively little precision around both the initial treatment and our ongoing monitoring of how effective the treatment is. You show up for scans now and again and hope that whatever you’ve been doing has been working.
Ben Woodington - who is an absolute unit - and the team at Coherence have come up with a new way to monitor and treat tumors. They’ve built an implant that, as the name suggests, gets placed inside the body to keep a constant watch on a tumor’s behavior. The chip also brings with it the ability to deliver electrical signals that may blunt a tumor’s growth. We’re talking constant monitoring of a tumor to see if treatments are working and the ability to read and write electrical signals as part of a totally novel bio-tech device.
In this episode, Ben explains how this technology works and, more broadly, he walks us through the emerging field of neuro-oncology or cancer neuroscience. We have a look at Coherence’s device, which is reminiscent of Neuralink’s implant, and rival technology.
Since we recorded this episode, Coherence has begun a study in Australia where its device is being used to record and stimulate brain activity in patients having brain tumors removed. The company has also put out a paper detailing some of its work and has brought on Neuralink’s neurosurgery lead Matthew MacDougall as an advisor and investor.
This episode was a treat for me because I had no idea this type of technology even existed, and because Coherence seems to have made a remarkable amount of progress on its hardware in a short time.
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OUR SPONSORS
SendCutSend
You know who else makes stuff for America? That would be SendCutSend. If you want to celebrate our great nation by building a metal part, then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.
Brex
The Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did.
We run on Brex and so should you. Learn more about Brex right here.
Timestamps (they link out to YouTube)
0:00 Intro3:54 Cut It, Poison It, Burn It. Is There a Fourth Way?6:16 Your Tumor Is Rewiring Your Brain8:29 The Clunky Device That Somehow Already Works11:35 Why Patients Take It Off15:12 Inside the Implant: A Neuralink for Tumors20:32 Could a Chip Replace the MRI?27:13 What the Mice Are Already Telling Them31:38 First Humans, and Why It's Always Australia35:36 "They Should Have Hired a Few Apple Engineers"43:24 Neuralink vs ONWARD: Who's Right About the Spine?47:09 The Idea Nobody Else in Neurotech Had1:01:45 Cut One Nerve and the Cancer Stops Spreading1:06:12 A Cancer Sensor Inside All of Us?1:09:12 Do Cancer Drugs Work Better Before 11 a.m.?1:14:59 If AI Ran Medicine, It Would Build This



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Running a media business is hard. You’re competing for people’s attention. You must produce a relentless stream of new things that are good and different. And you’re often dependent on the ever-changing whims of the public and advertisers.
John Coogan and Jordi Hays somehow made all of this look easy when they started TBPN in late 2024. The daily tech ne…

Prineha Narang is one of the rising stars of science and the field of quantum technology.
She earned her PhD in applied physics at Caltech, taught materials science at Harvard and now has her own lab at UCLA. The lab focuses on quantum materials, non-equilibrium dynamics, photonics, quantum information science and other easily digestible areas. Beyond her academic career, Narang is a science advisor to the government and a venture capitalist at DCVC.
As you might imagine, we get into quantum computing and quantum technology in this episode. Quantum vs. AI, the US vs. China, when quantum tech will break encryption, quantum sensing and whether or not quantum technology actually has a bright future. The quantum sensing portion of the chat was all new to me and rather astonishing.
Since Narang is also a competitive runner and mountaineer, we provide some top tips on gear because that is just the kind of all-purpose podcast that we deliver.
And, if you can’t get enough quantum computing, come check out our video episode on PsiQuantum building the largest quantum machine in history.
Enjoy!
OUR SPONSORS
SendCutSend
You know who else makes stuff for America? That would be SendCutSend. If you want to celebrate our great nation by building a metal part, then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you!
Brex
The Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did.
We run on Brex and so should you. Learn more about Brex right here.
Narang Lab at UCLA:
https://naranglab.ucla.edu
DCVC:
https://www.dcvc.com
Oratomic (the Caltech neutral atom spinout):
https://www.oratomic.com
Atom Computing:
https://atom-computing.com
Mesa Quantum:
https://mesaquantum.com
Google's work on the cost of quantum factoring: https://blog.google/security/tracking...NIST Post-Quantum Cryptography: https://csrc.nist.gov/projects/post-q...DARPA Quantum Benchmarking Initiative: https://www.darpa.mil/research/progra...Hyperlite Mountain Gear (the Dyneema packs Prineha swears by):
https://www.hyperlitemountaingear.com
Timestamps (they link out to YouTube)
00:00 Intro02:17 The Physicist Who Almost Became a Pro Runner13:39 A Cold Email, a Full Ride, and the Road to Caltech26:15 How Video Game Chips Quietly Took Over Science31:56 Is Quantum Losing the Spotlight to AI?40:50 "I Still Don't Believe in Quantum": Answering the Skeptics46:28 The Google Result That Could Break Encryption53:44 Is It Time to Panic About Q-Day?1:06:48 Quantum Sensing and the Case of Who Sneezed1:17:30 Does Consciousness Run on Quantum Rules?1:22:28 The Advice She Gives Terrified Students1:30:20 So When Does Quantum Actually Get Real?



This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

A few years ago, I was lunching with a young Australian man who told me he hoped to modernize manufacturing in America. This man seemed enthusiastic and ambitious, but I must confess to holding some serious doubts about the dramatic scope of his plans and his ability to pull them off.
This man was Chris Power, and, well, he did the thing. He’s the founder and CEO of Hadrian, which has a growing empire of mega factories packed full of machines that cut, bend and weld metal. Hadrian has become a workhorse for defense and aerospace and other big industries. It has used software to make it easier for people to control many machines at once and to keep track of the manufacturing process in a bid to add more quality control to industry.
Power has become one of the main players in the Reindustrialization movement and one of its more direct and critical voices.
We did this interview at Hadrian’s headquarters in Los Angeles with factories humming behind us, and we’ll have a video with all the machines soon on our YouTube channel. Chris and I get into his history, Hadrian’s history and the state of American manufacturing.
To celebrate AMERICAN MANUFACTURING and AMERICA and THE WORLD CUP and BEING SUBJECTED TO A BROKEN HEALTH INSURANCE SYSTEM, we’re offering a magnificent 4th of July merch SALE, SALE, SALE. Come get 30 percent off Core Memory’s hats, shirts and hoodies by using the promo code AMERICAAA right here.
OUR SPONSORS
SendCutSend
You know who else makes stuff for America? That would be SendCutSend. If you want to celebrate our great nation by building a metal part, then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.
Brex
The Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did.
We run on Brex and so should you. Learn more about Brex right here.
Timestamps (they link out to YouTube)
00:00 Intro
04:07 From Melbourne to a California Factory Floor
07:37 The Thesis He’d Work On for the Rest of His Life
10:00 How America Gave the Whole Farm Away
14:46 Why We Can’t Rebuild Our Own Missiles
19:08 Can You Really Put a Master Machinist Into Software?
24:38 From Missile Parts to the Entire Missile
29:19 The China Problem Nobody Wants to Say Out Loud
33:40 How Far Behind Is America Really?
41:45 “You Can’t Automate This.” Answering the Critics
45:22 Why Can’t Anyone Else Copy Tesla and SpaceX?
53:03 Can America Actually Build Its Own Shenzhen?



This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

If you spend any time inside a company that actually makes things in the U.S., then you’ll hear about SendCutSend.
Started in 2018, SendCutSend has become an American manufacturing phenomenon. The company makes metal parts for more than 300,000 customers, ranging from giants of aerospace and defense to hobbyists working on their cars. You ship SendCutSend a computer file of what you want built, and it often arrives at your house or factory the next day.
Jim Belosic started the company because he always had hardware side projects running in the background and wanted something like SendCutSend to exist. He spent $750,000 on his first metal cutting machine and then soon discovered that there were lots of other people like him who also wanted something like SendCutSend to exist.
The company has since evolved into one of the few homegrown options that can compete with China in terms of getting metal parts to customers quickly and at a reasonable price.
SendCutSend had been flying under the radar of the wider public for years with Belosic building the business largely with his own money and some smaller investments. Recently, though, SendCutSend raised $110 million from Sequoia, Paradigm, and Stripe founders Patrick and John Collison is now valued at $1 billion.
Our interview with Jim was conducted at SendCutSend’s headquarters in Reno and covers his history, the company’s history and the state of manufacturing in the U.S.
Full Disclosure: SendCutSend is a sponsor of the Core Memory podcast. This interview, for what it’s worth, took place before the company came on as a sponsor when my brain and soul were still objective.
Jim and I subsequently found a lot of overlap in what we care about and how we go about things. Our readers and viewers will know that we’re rather into folks who make things, and so is SendCutSend, so it’s quite the natural fit.
OUR SPONSORS
SendCutSend
Do you make stuff? Do you need metal parts fast and believe in truth and justice? Then head on over to SendCutSend where you’ll get a 15 percent discount thanks to Core Memory on whatever you’re trying to build. We believe in you.
Brex
The Core Memory podcast is also sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
Did we go to Texas, find a telescope ranch and then obtain an entire nebula in Brex’s honor? Oh yes, we did.
We run on Brex and so should you. Learn more about Brex right here.
Timestamps (Links head to YouTube)
00:00 Intro
04:09 What Does SendCutSend Actually Do?
06:01 The Black Market for One-Off Parts
08:31 The $750,000 Bet That Started It All
11:22 From Facebook Software to Cutting Metal
18:02 What on Earth Is a Teslonda?
24:31 The One Thing Nobody Else Tried
30:28 300,000 Customers, From Rockets to His Mom
35:23 Is Reindustrializing America Just Theater?
42:20 Why “Software First” Is a VC Trap
50:22 Is U.S. Manufacturing Stronger Than We Think?
1:03:42 Anodizing, Nevada, and What They Can Build Now
1:13:29 The One Competitor That Scares Him



This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe