The Sepsis Spectrum

• What's Next in Sepsis? | Season 2 Coming Soon!

  Season 2 is just around the corner for The Sepsis Spectrum! In this special bonus episode, Nicole Kupchik reflects on what we learned last season, how cancer can’t keep her away, and what’s next for the pod. Joining Nicole is Grady Health System Critical Care Clinical Nurse Specialist, Barbara McLean. Together, they have an honest, open conversation about sepsis, survivorship, and Season 2 which is all about sepsis and Multi Organ Dysfunction Syndrome (MODS). Plus, we’re calling for YOUR stories! Share real world cases and lived experiences with MODS to be featured in season two. To submit, visit: www.human-content.com/sepsis— Get in Touch: [email protected] Or Visit Us At: SepsisPodcast.org Connect with Nicole on Socials: @nicolekupchik Connect with Sepsis Alliance on Socials: @sepsisalliance To Learn More About Sepsis, Visit EndSuperbugs.org Produced by: Human Content and Sepsis Alliance

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• Are We Failing Sepsis Survivors Who Need Us Most?

  What you don’t track, you can’t fix, and too often, we’re not even looking. Nicole is joined by sepsis survivors Dr. Hilary Spangler and Jackie Duda, along with pediatric ICU nurse-scientist Dr. Mallory Perry-Eaddy, for a raw conversation about what happens after survival. From missed red flags in special populations to long-term trauma and broken feedback loops, this episode is a wake-up call for teams ready to see the full picture of sepsis care. Featured Guests: Hillary Spangler, MD (@http://linkedin.com/in/hillary-spangler): Internal medicine physician and health systems innovator focused on hospital quality, sepsis diagnostics, and patient-centered care. Mallory Perry-Eaddy, PhD, RN, CCRN (@ https://www.linkedin.com/in/mallory-perry/): Critical care nurse scientist and sepsis researcher studying ICU survivorship, racial disparities, and long-term recovery. Jackie Duda, Sepsis Survivor and Advocate (@jackiesjourney4): Sepsis survivor and advocate raising awareness of post-sepsis challenges and the vital role of caregiver voices in healthcare transformation. Key Takeaways: Understand why patients living with chronic disease (such as pediatrics, older adults, and the immunocompromised) need tailored approaches for infection prevention, AMR, and sepsis care. Recognize age- and population-specific pathogens—and why empiric antibiotic decisions carry different risks for different groups. Learn how antimicrobial stewardship can help protect vulnerable patients long-term by preserving their microbiome and slowing resistance. Explore how vaccination and proactive prevention strategies can play a frontline role in managing AMR and sepsis—especially in high-risk groups. Dive into the lasting impacts of AMR and sepsis in specialty populations and how those outcomes shape clinical decisions, recovery, and future risk. — Get in Touch: [email protected] Or Visit Us At: SepsisPodcast.org Connect with Nicole on Socials: @nicolekupchik Connect with Sepsis Alliance on Socials: @sepsisalliance To Learn More About Sepsis, Visit EndSuperbugs.org Produced by: Human Content and Sepsis Alliance

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• Can We Humanize Post-Sepsis Care?

  When crisis hits every layer of care, how do you keep patients feeling human? Nicole is joined by Dr. Mark Mikkelsen and sepsis survivor Katy Grainger for a raw and powerful conversation for a raw and powerful conversation on how sepsis survival is only the beginning of a long and often difficult journey. This episode takes a closer look at the physical, mental, and emotional challenges that many sepsis survivors face after leaving the hospital—struggles that can persist for months or even years. They'll examine current discharge and follow-up practices and envision a more connected, survivor-centered model of post-sepsis care; one that recognizes how AMR and readmission can complicate recovery, and how personalized recovery planning can make all the difference. Featured Guests: Mark Mikkelsen, MD, MSCE (@MarkMikkelsenMD): Pulmonary and critical care physician leading national work on sepsis definitions, data science, and care improvement strategies. Katy Grainger, Sepsis Survivor and Advocate (@Katysepsisamputee): Sepsis survivor and double amputee advocating for prevention, public awareness, and equitable care. Key Takeaways: Take a closer look at the physical, mental, and emotional hurdles sepsis survivors often face after hospital discharge. Understand how antimicrobial resistance can complicate recovery, especially for patients with long-term infections or limited access to follow-up care. Examine whether today’s discharge and follow-up practices are meeting the long-term needs of survivors or leaving them behind. Explore what a more connected post-sepsis care model could look like with better communication, structured check-ins, and survivor-centered planning. — Get in Touch: [email protected] Or Visit Us At: SepsisPodcast.org Connect with Nicole on Socials: @nicolekupchik Connect with Sepsis Alliance on Socials: @sepsisalliance To Learn More About Sepsis, Visit EndSuperbugs.org Produced by: Human Content and Sepsis Alliance

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• Can Patient Harm Drive Better Sepsis Prevention?

  Sometimes what we call prevention is really just harm repackaged. Nicole, Dr. Hudson Garrett, and Armando Nahum dig into the paradoxes of infection control, where well-meaning efforts can produce unseen consequences. They explore the culture of blame, AMR and sepsis awareness pitfalls, and the need to refocus on patient experience. A provocative discussion for infection preventionists and frontline clinicians and leaders alike. Featured Guests: Hudson Garrett, PhD, MSN, MPH, FNP-BC, IP-BC, CPPS, AS-BC, VA-BC, NCEE, FACDONA, DICO-C, CFER, FAAPM (https://www.linkedin.com/in/drhudsongarrett/)Infection prevention expert and healthcare epidemiologist focused on policy, implementation science, and safety culture. Website | X | Facebook Armando Nahum (https://www.linkedin.com/in/armandonahum/): National patient advocate and health equity leader who transformed personal tragedy into systemic change in hospital-acquired infection prevention, becoming the Co-Founder and President of the Safe Care Campaign https://www.safecarecampaign.org/ Key Takeaways: Understand how system failures in infection prevention and QI contribute to missed HAIs and hospital-onset sepsis. Identify safety blind spots like delayed recognition, antibiotic overuse, and communication breakdowns and why they persist. Explore how antimicrobial stewardship protects not just populations, but individual patients at their most vulnerable. Learn why real sepsis prevention takes more than protocols; it takes visibility, accountability, and leadership. — Get in Touch: [email protected] Or Visit Us At: SepsisPodcast.org Connect with Nicole on Socials: @nicolekupchik Connect with Sepsis Alliance on Socials: @sepsisalliance To Learn More About Sepsis, Visit EndSuperbugs.org Produced by: Human Content and Sepsis Alliance

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• Are Sepsis Protocols Ready for AI?

  How can we diagnose what we haven’t yet defined? Nicole welcomes Dr. Shamim Nemati and Dr. Gabriel Wardi to explore how artificial intelligence (AI) is reshaping sepsis detection. They dig into why existing definitions fall short, how data-driven tools can outperform traditional alerts, and where AI could take us next, from smarter antimicrobial stewardship to real-time clinical support. A conversation for anyone rethinking how we recognize and respond to sepsis. Featured Guests: Gabriel Wardi, MD, MPH, FACEP ( @WardiGabriel on X): Emergency medicine and critical care physician at UC San Diego focused on improving sepsis pathways, triage systems, and early intervention in acute care. Shamim Nemati, PhD (@ShamimNemati on X): Biomedical informatics researcher and AI scientist specializing in predictive analytics, machine learning, and sepsis risk modeling in real-time clinical settings. Key Takeaways: Clarify how artificial intelligence, machine learning, and traditional decision tools differ and how each is evolving to improve sepsis detection and antimicrobial stewardship. Explore how cutting-edge AI/ML models are helping close gaps in infection prevention, early sepsis detection, diagnostics, and resistance forecasting. Learn how these tools are being applied to risk prediction, therapy selection, and alert refinement across hospital workflows. Walk away with real-world examples and design insights to help improve diagnostic precision and clinical decision support in your own system. — Get in Touch: [email protected] Or Visit Us At: SepsisPodcast.org Connect with Nicole on Socials: @nicolekupchik Connect with Sepsis Alliance on Socials: @sepsisalliance To Learn More About Sepsis, Visit EndSuperbugs.org Produced by: Human Content and Sepsis Alliance

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