The Human Upgrade with Dave Asprey

• Military Tech Goes Public: Think 30% Faster with This Brain Hack | Geoffrey Woo : 1282

  Your brain runs slow when it’s running on the wrong fuel. In this episode of The Human Upgrade, Dave Asprey sits down with Geoffrey Woo, Stanford-trained computer scientist and founder of Ketone-IQ, to reveal the high-performance brain fuel once reserved for Special Forces and elite athletes. Discover how ketones helped operators in combat zones sharpen focus, recover faster, and boost reaction speed by up to 30%. Learn why glucose falls short, how to hack your mitochondria for better cognition, and what it takes to unlock rapid-fire thinking on demand. This is brain energy for people who want to win, at life, work, and everything in between. Whether you’re fasting, flying, or facing real pressure, ketones flip the switch. You’ll Learn: • Why ketones beat glucose for focus, speed, and mental clarity • How Special Forces use ketones to recover brain function under stress • The truth about esters, salts, and the new wave of ketone diols • How ketones support faster thinking, emotional control, and clean energy • What makes Ketone-IQ different, and how Dave stacks it for peak performance • The best ways to combine ketones with fasting, workouts, and meditation • Why your metabolism controls your mood, reaction time, and resilience Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Ketone-IQ Website – https://ketone.com/pages/dave-asprey?utm_source=partners&utm_medium=referral&utm_campaign=DAVE • Geoffrey's Website: https://www.geoffreywoo.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 02:00 – Intro • 02:12 – Ketosis & brain performance • 02:53 – Geoffrey’s background • 03:52 – Ketone supplement evolution • 04:41 – What makes Ketone-IQ different • 07:18 – Manufacturing breakthroughs • 13:53 – Entrepreneur mindset • 18:58 – Future of biohacking • 45:59 – Why classics still matter • 46:23 – Cultural decline • 47:04 – Decentralization • 48:25 – Info overload & mental clarity • 49:38 – Ketones & consciousness • 57:49 – Religion & belief systems • 01:03:32 – Key biohacking biomarkers • 01:12:47 – Brain data & future upgrades • 01:26:34 – Listener offer See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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• The Anti-Aging Chamber That Rewinds Your Biological Clock|Dr. Jason Sonners : 1281

  Your cells are starving. Not for food—but for oxygen. In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Jason Sonners, world-renowned hyperbaric expert and regenerative medicine pioneer, to reveal how controlled oxygen under pressure is becoming one of the most powerful tools in anti-aging and performance science. You’ll learn how hyperbaric oxygen therapy (HBOT) triggers stem cell activation, rewires your epigenome, boosts mitochondrial energy, and reverses biological aging—if you use it the right way. Jason shares breakthrough findings from his latest PhD research comparing low- and high-pressure chambers, with surprising results on inflammation, telomeres, cognitive performance, and recovery speed. This is next-gen longevity—measurable, stackable, and customizable. From sleep upgrades and HRV boosts to stacking HBOT with fasting, methylene blue, or red light, this episode dives into what it takes to oxygenate your biology at the deepest level. You’ll Learn: • How hyperbaric oxygen therapy (HBOT) triggers stem cell regeneration and cellular repair • Why mild-pressure chambers may be more powerful than you think• What HBOT does to inflammation, brain fog, and biological aging markers • How to stack HBOT with fasting, red light, and methylene blue for amplified results • What Dr. Sonners’ PhD research reveals about oxygen pressure and genetic expression • The truth about oxygen toxicity—and how to avoid the common mistakes • How elite performers use HBOT for brain optimization, recovery, and resilience ** Get 30% of yourr tickets to the Biohacking conference by going to https://biohackingconference.com/2025 and use code ‘OXYHEALTH’ ** Thank you to our sponsors! -Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Jason's Website – www.hbotusa.com • OxyHealth Website: https://www.oxyhealth.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:59 Intro • 03:14 New research on aging and oxygen • 05:39 Mild vs. hard-shell chambers • 13:05 HBOT for longevity and stem cells • 16:43 How to optimize your sessions • 22:35 Best therapies to stack with HBOT • 25:40 Oxygen delivery and safety • 26:43 Altitude and chamber effects • 30:01 Key benefits of hyperbaric therapy • 34:22 Supplement synergy and timing • 37:25 Pressure and oxygenation findings • 39:27 Medical vs. welding oxygen • 44:57 Safety myths and toxicity risks • 47:39 Future of biohacking with oxygen See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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• The New Science Behind Psychedelics, Exotic Shrooms, & Daily Flow-States | Matt Zemon : 1280

  Your brain has a gear you’ve never touched. Psychedelics can shift you into it. In this episode of The Human Upgrade, Dave Asprey uncovers how high-performance psychedelic mushrooms help you access flow states, rewire your brain, and enhance clarity, energy, and emotional resilience. This is next-level biohacking rooted in real science. You will learn how to use psychedelics with intention. When to microdose. When to go deep. How to stack them with nootropics for even stronger results. Dave breaks down the latest research on psilocybin, brain plasticity, trauma release, and how to turn ancient compounds into modern performance tools. What You Will Learn in This Episode: • How psychedelic shrooms unlock flow, focus, and creative power • Why psilocybin boosts neuroplasticity, mood, and emotional healing • Microdosing vs. full-dose: what works, when, and how • How to stack psychedelics with nootropics and other biohacks • The newest research on brain optimization and long-term benefits • How to use psychedelics safely, strategically, and for real results • Why shrooms may be the strongest mental upgrade in your toolkit Thank you to our sponsors! -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Matt’s Website – https://mattzemon.com/ • Matt's Instagram - https://www.instagram.com/matt.zemon/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 01:00 – Intro • 06:01 – Personal Psychedelic Journeys • 07:39 – Psychedelics and Self-Discovery • 11:59 – Safe Use and Smart Navigation • 29:09 – Psychedelics and Society • 36:40 – Building Trust in the Process • 37:14 – Facing Inner Fear • 37:38 – Choice and Healing • 37:51 – Diet and Conscious Decisions • 38:55 – Judgment and Relationships • 39:29 – Spirituality and Psychedelics • 40:07 – The Entheogenic Reformation • 41:29 – Past Lives and Expanded States • 43:44 – Where Science Meets Spirituality • 49:59 – Gratitude and Compassion in Healing • 01:01:47 – The Power of Apologies • 01:04:56 – Psychedelics in Therapy • 01:08:57 – Final Thoughts on Psychedelics and Culture See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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• Why Oral Testosterone Is the Ultimate Upgrade for Energy, Mood and Longevity (Men AND Women) | Shalin Shah : 1279

  Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it. In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before. You will discover why testosterone is essential for dopamine, brain function, sleep, muscle, libido, and mitochondrial health. Fixing your levels can reverse fatigue, brain fog, poor motivation, and slow aging itself. Shalin reveals how new oral testosterone technology (Kyzatrex®) overcomes the dangers of old therapies and restores natural hormone rhythms without needles, creams, or dangerous side effects. What You Will Learn in This Episode: • Why testosterone matters for men and women at every age • The real causes of the global testosterone crash • Why diet, sleep, and exercise cannot fully fix low testosterone • How testosterone drives dopamine, motivation, and longevity • The breakthrough that makes oral testosterone safe and effective • How Kyzatrex® lowers SHBG and boosts free testosterone naturally • Why maintaining youthful testosterone levels protects brain, muscle, libido, and lifespan • How to safely use testosterone therapy without suppressing fertility or causing side effects ** Visit livethrive.co/asprey to get a discount on your first month's supply! ** Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Purchase Kyzatrex® – https://livethrive.co/?utm_campaign=11813552-Asprey• Shalin’s Instagram - https://www.instagram.com/themetabolicceo/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: 00:00 Trailer 00:52 Introduction 01:29 Global Decline in Testosterone Levels 02:27 Symptoms of Low Testosterone 03:48 Personal Journey with Testosterone Therapy 05:06 The Role of Testosterone in Overall Health 06:18 Testosterone Levels in Men and Women 08:48 Challenges and Innovations in Testosterone Delivery 16:25 The Importance of Circadian Rhythm in Testosterone Therapy 19:19 The Future of Testosterone Therapy 32:00 Investment and Development in Testosterone Therapy 34:57 Introduction to FDA and Hormone Replacement 35:31 FDA’s Impact on Women’s Health 36:10 Testosterone and Cardiovascular Risk 39:05 Testosterone and Depression 40:30 Testosterone Testing and Misconceptions 44:58 The Testosterone Project and Female Hormone Therapy 47:51 Testosterone’s Role in Longevity and Health 55:37 Cost and Accessibility of Testosterone Therapy 01:04:03 Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  1:05:01
• The Deadliest Room in Your House — And How to Detox It for Better Health | Aly Cohen MD : 1278

  Your environment is rewiring your hormones, fertility, and long-term health without your consent. In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Aly Cohen, board-certified rheumatologist, integrative medicine specialist, and environmental health educator. Together they expose how common toxins in plastics, pesticides, drinking water, personal care products, and food packaging are hijacking your biology. Dr. Cohen explains how daily chemical exposures contribute to autoimmune disease, thyroid dysfunction, hormone imbalance, infertility, obesity, cancer, and accelerated aging. You will learn how to identify hidden endocrine disruptors, spot surprising sources of microplastics and PFAS (“forever chemicals”), and apply science-backed detox strategies to protect your hormones, fertility, metabolism, and longevity. What You’ll Learn in This Episode: • How chemicals in household, cleaning, and beauty products disrupt hormones • The link between environmental toxins, autoimmune disease, thyroid issues, and infertility • Hidden sources of microplastics and PFAS chemicals and how to eliminate them • Affordable, practical steps to detox your home, water, and personal care routine • Dr. Cohen’s top biohacks to protect fertility, balance hormones, and build toxin resilience THANK YOU TO OUR SPONSORS! -BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Aly’s Website – https://thesmarthuman.com/ • Aly's Website - https://alycohenmd.com/ • Aly’s New Book – Detoxify: https://alycohenmd.com/books • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: 00:00 Trailer 02:01 Introduction 02:15 Rheumatism and Rheumatology 03:36 Autoimmune Diseases and Toxins 04:17 Chemical Impact on Health 04:49 Personal Health Journey 06:15 Microplastics and Immune Disruption 08:21 Resilience and Lifestyle Changes 21:45 Nutritional Deficiencies 26:48 Lab Results and Assessments 34:40 Detoxification and Resilience 41:14 Personal Journey Continued 42:22 Clean Drinking Water 44:20 Travel Hacks for Water 46:15 Hotel Room Detox Tips 50:06 EPA Water Standards 53:06 Restaurant Toxins and Home Safety 55:36 Top Toxic Household Items 01:08:31 Synthetic Materials Impact 01:13:30 Final Thoughts and Book See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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