The School of Doza Podcast

Your mood struggles might not be a mindset problem — they might be a methylation problem. In this episode, Nurse Doza breaks down the TMG supplement (trimethylglycine), how it drives serotonin and dopamine production, and why pairing it with SAMe in BLISS delivers clean energy and mood support — no caffeine, no stimulants, results in minutes.

Featured Partner: MSW Nutrition — BLISS
BLISS by MSW Nutrition combines two of the most underutilized mood-support compounds in functional medicine — trimethylglycine (TMG) and SAMe — in a fast-absorbing sublingual powder. Together, they fuel the methylation pathways your body needs to produce serotonin, dopamine, and sustainable energy — exactly the mechanisms Nurse Doza unpacks in this episode. No caffeine. No fillers. No stimulants. Just the two ingredients your brain chemistry has been waiting for.
👉 Get BLISS here: bliss.mswnutrition.com

5 Key Takeaways
1. TMG is a methyl donor, not a stimulant.
Unlike caffeine or pre-workout compounds, trimethylglycine works by donating methyl groups to critical biochemical pathways. This directly supports the production of serotonin, dopamine, and norepinephrine — the neurotransmitters behind mood, motivation, and mental clarity.
2. The MTHFR gene affects more people than doctors realize.
Variants in the MTHFR gene reduce the body’s ability to convert folate into active methylfolate, impairing neurotransmitter synthesis. Research shows 74% of treatment-resistant depression cases test positive for MTHFR polymorphism. The TMG supplement directly supports this compromised methylation pathway.
3. SAMe is one of the most clinically studied mood compounds available.
A 2024 meta-analysis of 23 randomized controlled trials (N=2,234) confirmed that SAMe produced significantly greater reductions in depressive symptoms compared to placebo. TMG raises SAMe levels in the body — making the BLISS stack a powerful, evidence-backed combination.
4. Sublingual delivery accelerates results.
BLISS is formulated as a sublingual powder, bypassing the digestive tract and delivering TMG and SAMe directly into the bloodstream. That’s why users can feel a difference in seconds to minutes — not hours. The absorption advantage is real.
5. This is clean energy — not stimulant energy.
The energy benefit of BLISS is neurotransmitter-driven, not caffeine-driven. By supporting healthy dopamine and serotonin levels, TMG and SAMe restore the natural energy and focus that emerges when your brain chemistry is actually balanced. No crash. No dependency.

Resources
“Efficacy and acceptability of S-adenosyl-L-methionine (SAMe) for depressed patients: A systematic review and meta-analysis”
2024 meta-analysis of 23 randomized controlled trials (N=2,234) demonstrating SAMe showed significantly greater reduction in depressive symptoms compared to placebo, establishing it as a well-tolerated, evidence-backed mood support compound.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863058/
“MTHFR Gene Polymorphism Positive Treatment-Resistant Depression: Prevalence and Treatment Recommendations”
Peer-reviewed analysis showing 74% of treatment-resistant depression cases tested positive for MTHFR genetic polymorphism, with methylation support identified as a primary intervention pathway — directly validating TMG’s role in mood support.
https://www.jneuropsychiatry.org/peer-review/mthfr-gene-polymorphism-positive-treatmentresistant-depression-prevalence-and-treatment-recommendations.html
“Investigation of betaine as a novel psychotherapeutic”
PMC study demonstrating betaine (TMG) supplementation improved cognitive performance and suppressed abnormal behavioral responses in animal models, highlighting its role in brain methylation and neurological health.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6642071/
“S-adenosylmethionine blood levels in major depression: changes with drug treatment”
PubMed clinical trial finding 62% of SAMe-treated patients showed significant improvement, with plasma SAMe levels directly correlated to the degree of clinical improvement in depressed patients — regardless of treatment type.
https://pubmed.ncbi.nlm.nih.gov/7941961/
“Betaine: A Nutrient with Multiple Health-Promoting Effects”
Comprehensive MDPI review covering betaine’s (TMG’s) biological roles as a methyl donor in methylation balance, epigenetic regulation, mitochondrial function, and its evidence-based effects on cognitive, cardiovascular, and metabolic health across species.
https://www.mdpi.com/2076-3921/14/7/771

Connect with Nurse Doza
🔗 JOIN MY SCHOOL for FREE: community.schoolofdoza.com/c/start-here
YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA
Instagram: https://www.instagram.com/nursedoza/
Website: http://www.nursedoza.com/
LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/
TikTok: https://www.tiktok.com/@nursedoza
Twitter: https://twitter.com/nursedoza

Dopamine controls your motivation, focus, mood, and reward system — and most people are running low without realizing it. In this episode, Nurse Doza breaks down what dopamine actually does in the body, why deficiency is far more common than most people think, how your gut produces 50% of it, and the natural steps you can take to restore healthy levels.

FEATURED PRODUCT: BLISS
Bliss by MSW Nutrition is a lemon-flavored sublingual powder built around SAMe and TMG — two powerful methyl donors that directly support your body’s natural dopamine and serotonin production through the methylation pathway. If you’re feeling flat, foggy, or low-mood, methylation may be the missing link. One powder stick dissolved on your tongue — no water needed — and you may feel the difference within seconds to minutes. Bliss also supports glutathione production, liver health, and MTHFR function, making it one of the most targeted neurotransmitter support supplements available.

👉 Get Bliss here: https://mswnutrition.com/products/bliss

5 KEY TAKEAWAYS
Your lifestyle drives dopamine production — morning sunlight, exercise, quality sleep, music, and meditation are all proven natural dopamine boosters your body responds to every single day.
Most people are dopamine deficient — driven by overstimulation, poor sleep, gut dysfunction, and modern demands that drain the system faster than it can replenish.
50% of your dopamine is made in your gut — digestive issues like bloating, SIBO, leaky gut, or dysbiosis can directly tank your mood, focus, and motivation.
Dopamine is the engine behind addiction — when levels are chronically low or the reward system is dysregulated, the brain compulsively seeks dopamine hits from food, substances, screens, risky behavior, or work.
Key nutrients support natural dopamine synthesis — Vitamin B6, B9 (folate), iron, Vitamin C, and SAMe are essential cofactors in the dopamine production pathway and can be supported through targeted supplementation.

TIMESTAMPS
00:00 START – Welcome and episode overview
02:00 – What dopamine is and why so many people are running low
04:00 – School of Doza: MTHFR course announcement
05:00 – The 5 things you need to know about dopamine
05:30 – #1: Healthy ways to naturally produce dopamine
07:00 – Morning sunlight, exercise, sleep, music, and meditation
08:00 – #2: Why most people are dopamine deficient
09:30 – #3: How the gut produces 50% of your dopamine
12:00 – Dopamine receptors found throughout the entire body
13:30 – Dopamine’s conversion pathway to norepinephrine and adrenaline
15:00 – #4: How dopamine drives addiction and compulsive behavior
18:30 – The neuroscience of hugs and emotional connection
20:00 – Opioid addiction through the lens of dopamine deficiency
21:00 – #5: Natural nutrients that support dopamine production
24:00 – Bliss by MSW Nutrition, action steps, and closing thoughts

JOIN THE SCHOOL OF DOZA
If today’s episode on dopamine left you with questions about your own focus, mood, or motivation — the School of Doza is where you go to get real answers. Inside, you’ll find a community of people actively working on the same things you are: gut health, neurotransmitter support, energy, mental clarity, and sustainable lifestyle habits. Every Wednesday, Nurse Doza hosts a live AMA session that functions as a group consult — the kind of access that typically takes months to book privately. You bring your questions, he brings the clinical insight. Whether you’re navigating dopamine deficiency, gut issues, or just want a clear and personalized plan — this is your room.

👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

RESOURCES
1. SAMe and Neurotransmitter Synthesis — https://pmc.ncbi.nlm.nih.gov/articles/PMC11435340/
2. How to Increase Dopamine Naturally — https://www.healthline.com/nutrition/how-to-increase-dopamine#fa-qs
3. Dopamine Metabolism and the Gut-Brain Axis —  https://pmc.ncbi.nlm.nih.gov/articles/PMC11469830/
4. Gut Microbiome and Dopaminergic Pathways — https://www.mdpi.com/2306-5354/13/1/55
5. B Vitamins and Neurotransmitter Production — Examines how B6 and folate serve as rate-limiting cofactors in dopamine and serotonin synthesis. https://pmc.ncbi.nlm.nih.gov/articles/PMC4772032/
6. Good Poops Protocol by MSW Nutrition — Gut health supplement bundle to support the microbiome and neurotransmitter production. https://goodpoops.org
7. Bliss by MSW Nutrition — Sublingual SAMe and TMG powder supporting methylation, dopamine, and serotonin production. https://mswnutrition.com/products/bliss

CONNECT
🔗 Connect with Nurse Doza:
JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here
YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA
Instagram: https://www.instagram.com/nursedoza/
Website: http://www.nursedoza.com/
LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/
TikTok: https://www.tiktok.com/@nursedoza
Twitter: https://twitter.com/nursedoza

What if a single gene is quietly affecting your mood, energy, sleep, and focus — and most doctors never test for it? In this episode of the Longevity Series, Nurse Doza breaks down MTHFR gene support: what methylation is, why this gene matters, and how BLISS by MSW Nutrition delivers targeted sublingual support — sometimes with noticeable results the same day.

BLISS by MSW Nutrition is a sublingual powder formulated with two active ingredients specifically designed to support the MTHFR gene and the methylation cycle. For people with MTHFR variants — who may struggle with mood regulation, low energy, brain fog, and disrupted sleep — BLISS bypasses the digestive process entirely, delivering its active compounds directly into the bloodstream under the tongue for fast, efficient absorption. Nurse Doza and co-founder Baldo both have confirmed MTHFR issues and take BLISS daily — this is a supplement built from personal need, not theory. One box contains 30 packets, making it a full 30-day protocol.

👉 Try BLISS with code BLISSMAY at: https://bliss.mswnutrition.com

5 Key Takeaways
MTHFR gene variants are far more common than most people realize. Approximately 30–40% of people carry a variant of the MTHFR gene that reduces enzyme efficiency — sometimes by as much as 70%. If you’ve ever been dismissed with “normal” labs while still feeling off, this gene may be the missing piece.

Methylation controls more of your health than you think. The methylation cycle governs neurotransmitter production, detoxification, hormone regulation, and DNA repair. When MTHFR impairs this pathway, mood, energy, digestion, and long-term health can all be affected.

Low serotonin from poor methylation can wreck your sleep. Because serotonin is the precursor to melatonin, impaired methylation can directly disrupt your sleep-wake cycle. Supporting the MTHFR pathway can help restore the serotonin–melatonin conversion your body needs for deep, restorative sleep.

Sublingual delivery changes the absorption game. Traditional capsules and powders can lose significant potency through first-pass digestion. BLISS is a sublingual powder that bypasses the GI tract entirely, entering the bloodstream directly through the oral mucosa for faster, more efficient delivery.

You can override poor genetics with the right support. Having an MTHFR variant is not a life sentence. Targeted methylation support through active-form nutrients can help compensate for reduced enzyme activity, improving neurotransmitter output and overall cellular function.

Resources

“Methylenetetrahydrofolate Reductase and Psychiatric Diseases” — PMC, NCBI
Peer-reviewed research examining how MTHFR gene mutations affect one-carbon metabolism and their established link to psychiatric disorders, mood regulation, and neurotransmitter synthesis including serotonin and dopamine. https://pmc.ncbi.nlm.nih.gov/articles/PMC6218441/

“Discovery of MTHFR Deficiency in Individuals With Common Psychiatric Comorbidities” — PMC, NCBI
Retrospective case review from PMC establishing the connection between MTHFR deficiency and common psychiatric presentations, with focus on neurotransmitter pathways including serotonin, norepinephrine, and dopamine. https://pmc.ncbi.nlm.nih.gov/articles/PMC11088868/

“Chronic Insomnia in the Setting of MTHFR Polymorphism” — Journal of Clinical Sleep Medicine, PMC
Published case study documenting treatment-resistant chronic insomnia successfully resolved by targeting MTHFR polymorphism, demonstrating the serotonin–melatonin–sleep connection and the role of methylation support in restoring sleep quality. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974368/

“Sublingual and Buccal Delivery: A Historical and Scientific Prescriptive” — PMC, NCBI
Comprehensive review of sublingual and buccal delivery mechanisms, demonstrating how this route bypasses first-pass hepatic metabolism and leverages the oral mucosa’s rich vascular network for faster, more efficient systemic absorption versus standard oral supplementation. https://pmc.ncbi.nlm.nih.gov/articles/PMC12389210/

“The MTHFR Gene Mutation and Its Connection to Mental Health” — Genomind
Evidence-based overview of how MTHFR gene variants reduce the body’s ability to convert vitamin B9 into active methylfolate, directly impacting neurotransmitter synthesis and predisposing individuals to low mood, low energy, and cognitive difficulties. https://genomind.com/patients/mthfr-and-the-role-it-plays-in-your-mental-health/

Connect with Nurse Doza
🔗 JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here
• YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA
• Instagram: https://www.instagram.com/nursedoza/
• Website: http://www.nursedoza.com/
• LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/
• TikTok: https://www.tiktok.com/@nursedoza
• Twitter: https://twitter.com/nursedoza

Chronic stress belly fat is more than a feeling — it changes your hormones, metabolism, and cravings. Nurse Doza breaks down 5 specific mechanisms — cortisol, insulin resistance, leptin dysfunction, fatty liver, and late-night eating — explaining exactly why belly fat won't budge and what to do about it.

FEATURED PRODUCT: 
The Metabolic Pack from MSW Nutrition is the complete protocol for everything covered in this episode. Liver Boost combines turmeric (curcumin), green tea extract (EGCG), NAC, and alpha-lipoic acid to reduce inflammation, support liver detoxification, and combat insulin resistance at the cellular level. Mitochondriac delivers resveratrol and key mitochondrial support to activate AMPK, improve cellular energy, and lower inflammatory markers linked to chronic stress and weight gain. Zen contains an adaptogenic blend with Rhodiola, Ginseng, Eleuthero, Schisandra, and bovine adrenal glandular support — specifically designed to regulate cortisol and protect adrenal health. Together, these three supplements form a 60–90 day metabolic reset built to address the root causes of chronic stress belly fat.

👉 Get the Metabolic Pack here: https://mswnutrition.com/collections/bundles/products/metabolic-pack

JOIN THE SCHOOL OF DOZA
Still trying to figure out why the belly fat won't budge despite doing everything right? You're not alone — and generic advice isn't enough. Inside the School of Doza, you'll find a community of people working through the same hormonal, metabolic, and stress-related challenges covered in this episode. Every Wednesday, Nurse Doza hosts a live Ask Me Anything that works exactly like a group consult — bring your cortisol questions, your labs, your weight loss frustrations, and get real answers. Your first 7 days are completely free.

👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

5 KEY TAKEAWAYS
Cortisol is not the villain — it's essential. 
Insulin resistance is the engine behind belly fat 
You may be eating when you are not actually hungry. 
Fatty liver and belly fat are directly connected. 
When you eat matters as much as what you eat. 

TIMESTAMPS
00:00 – START 
01:03 – The connection between chronic stress, cortisol, and belly fat
03:30 – Why cortisol is not the villain 
05:00 – Cortisol — how chronic elevation drives fat storage
06:00 – Insulin resistance — the real driver of weight gain
07:25 – Ozempic, GLP-1 agonists, and why they don't fix the root cause
09:53 – Natural compounds for insulin resistance: berberine, curcumin, EGCG, resveratrol
16:43 – Leptin resistance — eating when you are not actually hungry
21:00 – Fasting as the most sustainable tool for lowering leptin and insulin
23:51 –Fatty liver — the overlooked driver of belly fat
26:42 – The global obesity crisis and the limits of pharmaceutical solutions
28:50 – Eating late at night disrupts melatonin and glucose tolerance

RESOURCES
1. Cortisol and Weight Gain (HPA Axis and Obesity Review) —  https://pmc.ncbi.nlm.nih.gov/articles/PMC9285588/
2. Visceral Adipose Tissue, 11β-HSD1, and Metabolic Syndrome https://pmc.ncbi.nlm.nih.gov/articles/PMC4517681/
3. Natural Polyphenols and Obesity-Induced Insulin Resistance https://pmc.ncbi.nlm.nih.gov/articles/PMC12872655/
4. Leptin, Leptin Resistance, and Obesity  https://pmc.ncbi.nlm.nih.gov/articles/PMC8167040/
5. Fatty Liver (NAFLD) and Obesity https://pmc.ncbi.nlm.nih.gov/articles/PMC3575093/
6. Nighttime Eating and Weight Gain https://pmc.ncbi.nlm.nih.gov/articles/PMC6322536/
7. Nighttime Macronutrient Intake and Insulin Resistance https://pmc.ncbi.nlm.nih.gov/articles/PMC4425165/
8. Meal Timing, Late Dinner, and Weight Loss Difficulty https://pmc.ncbi.nlm.nih.gov/articles/PMC6893547/
9. Hume Health BodyPod — At-Home Body Composition Measurement (use code NURSEDOZA) https://humehealth.com

CONNECT
🔗 Connect with Nurse Doza:
JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here
YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA
Instagram: https://www.instagram.com/nursedoza/
Website: http://www.nursedoza.com/
LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/
TikTok: https://www.tiktok.com/@nursedoza
Twitter: https://twitter.com/nursedoza

Chronic stress belly fat is more than a feeling — it changes your hormones, metabolism, and cravings. Nurse Doza breaks down 5 specific mechanisms — cortisol, insulin resistance, leptin dysfunction, fatty liver, and late-night eating — explaining exactly why belly fat won't budge and what to do about it.

FEATURED PRODUCT: 
The Metabolic Pack from MSW Nutrition is the complete protocol for everything covered in this episode. Liver Boost combines turmeric (curcumin), green tea extract (EGCG), NAC, and alpha-lipoic acid to reduce inflammation, support liver detoxification, and combat insulin resistance at the cellular level. Mitochondriac delivers resveratrol and key mitochondrial support to activate AMPK, improve cellular energy, and lower inflammatory markers linked to chronic stress and weight gain. Zen contains an adaptogenic blend with Rhodiola, Ginseng, Eleuthero, Schisandra, and bovine adrenal glandular support — specifically designed to regulate cortisol and protect adrenal health. Together, these three supplements form a 60–90 day metabolic reset built to address the root causes of chronic stress belly fat.

👉 Get the Metabolic Pack here: https://mswnutrition.com/collections/bundles/products/metabolic-pack

JOIN THE SCHOOL OF DOZA
Still trying to figure out why the belly fat won't budge despite doing everything right? You're not alone — and generic advice isn't enough. Inside the School of Doza, you'll find a community of people working through the same hormonal, metabolic, and stress-related challenges covered in this episode. Every Wednesday, Nurse Doza hosts a live Ask Me Anything that works exactly like a group consult — bring your cortisol questions, your labs, your weight loss frustrations, and get real answers. Your first 7 days are completely free.

👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

5 KEY TAKEAWAYS
Cortisol is not the villain — it's essential. 
Insulin resistance is the engine behind belly fat 
You may be eating when you are not actually hungry. 
Fatty liver and belly fat are directly connected. 
When you eat matters as much as what you eat. 

TIMESTAMPS
00:00 – START 
01:03 – The connection between chronic stress, cortisol, and belly fat
03:30 – Why cortisol is not the villain 
05:00 – Cortisol — how chronic elevation drives fat storage
06:00 – Insulin resistance — the real driver of weight gain
07:25 – Ozempic, GLP-1 agonists, and why they don't fix the root cause
09:53 – Natural compounds for insulin resistance: berberine, curcumin, EGCG, resveratrol
16:43 – Leptin resistance — eating when you are not actually hungry
21:00 – Fasting as the most sustainable tool for lowering leptin and insulin
23:51 –Fatty liver — the overlooked driver of belly fat
26:42 – The global obesity crisis and the limits of pharmaceutical solutions
28:50 – Eating late at night disrupts melatonin and glucose tolerance

RESOURCES
1. Cortisol and Weight Gain (HPA Axis and Obesity Review) —  https://pmc.ncbi.nlm.nih.gov/articles/PMC9285588/
2. Visceral Adipose Tissue, 11β-HSD1, and Metabolic Syndrome https://pmc.ncbi.nlm.nih.gov/articles/PMC4517681/
3. Natural Polyphenols and Obesity-Induced Insulin Resistance https://pmc.ncbi.nlm.nih.gov/articles/PMC12872655/
4. Leptin, Leptin Resistance, and Obesity  https://pmc.ncbi.nlm.nih.gov/articles/PMC8167040/
5. Fatty Liver (NAFLD) and Obesity https://pmc.ncbi.nlm.nih.gov/articles/PMC3575093/
6. Nighttime Eating and Weight Gain https://pmc.ncbi.nlm.nih.gov/articles/PMC6322536/
7. Nighttime Macronutrient Intake and Insulin Resistance https://pmc.ncbi.nlm.nih.gov/articles/PMC4425165/
8. Meal Timing, Late Dinner, and Weight Loss Difficulty https://pmc.ncbi.nlm.nih.gov/articles/PMC6893547/
9. Hume Health BodyPod — At-Home Body Composition Measurement (use code NURSEDOZA) https://humehealth.com

CONNECT
🔗 Connect with Nurse Doza:
JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here
YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA
Instagram: https://www.instagram.com/nursedoza/
Website: http://www.nursedoza.com/
LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/
TikTok: https://www.tiktok.com/@nursedoza
Twitter: https://twitter.com/nursedoza