UnHack with Drex DeFord

December 23, 2025: The AI revolution swept through healthcare in 2025, but did it deliver on its promises? Bill Russell, Drex DeFord, and Sarah Richardson pull back the curtain on what really happened in AI this year—from North Korean deep fakes infiltrating hospital workforces to the sobering reality of billion-dollar AI investments with ROI timelines stretching to 2030. They reveal why ambient listening became the breakout use case, which organizations are actually making progress, and the critical mistake most health systems are making with endless pilots. If you're wondering whether your organization is behind on AI or just getting started right, this honest end-of-year reflection delivers the answers healthcare leaders need heading into 2026.Key Points:02:38 2025 Reflections and Predictions11:21 Deep Fakes and Digital Trafficking in Healthcare17:50 Balancing Tech Debt and Innovation in Healthcare19:22 Enhancing Physician Efficiency and Satisfaction25:09 Future AI Trends X: This Week HealthLinkedIn: This Week HealthDonate: Alex’s Lemonade Stand: Foundation for Childhood Cancer

December 19, 2025: CMS has unveiled its new ACCESS Model—an ambitious 10-year initiative aimed at expanding digital, tech-enabled care for millions of Medicare beneficiaries. In this discussion, Laura O’Toole, CEO of SureTest, joins Bill and Sarah to unpack how outcome-based reimbursement could finally accelerate innovation in remote monitoring and chronic disease management. They explore what this shift means for CIOs, including the need for stronger data interoperability, integrated analytics, and secure pipelines to support continuous digital care. The conversation also highlights risks, from digital literacy gaps to patient privacy concerns as de-identified data gains value across the industry. From wearables and home health devices to the challenge of building a true digital front door, this episode examines how ACCESS could reshape care-in-place models—and why commercial payers may soon follow Medicare’s lead.X: This Week HealthLinkedIn: This Week HealthDonate: Alex’s Lemonade Stand: Foundation for Childhood Cancer

From crippling outages to AI-powered deepfakes, 2025 tested healthcare cybersecurity like never before. This year-end recap explores the moments that mattered most: how teams built resilience during system failures, why users became partners instead of "weak links," how identity became the new perimeter, and what it means when you can't trust your own eyes. Through powerful stories from the front lines, we revisit the lessons learned and the community that kept us standing. Because at the end of the day, cybersecurity is patient safety, and the work you do saves lives.

A critical vulnerability called React to Shell exposed tens of thousands of systems worldwide, triggering immediate exploitation by threat actors—including China-nexus groups—within minutes of disclosure. Drex breaks down how this flaw turns innocent web requests into remote access backdoors, why CloudFlare's emergency response accidentally caused widespread outages, and what this high-stakes race teaches us about rapid response patching in healthcare. When attackers move at internet speed, your playbook needs to be faster than your Slack discussion.Remember, Stay a Little Paranoid X: This Week Health LinkedIn: This Week Health Donate: Alex’s Lemonade Stand: Foundation for Childhood Cancer

December 15, 2025: What if healthcare's biggest breakthroughs require throwing out the playbook? Joined by Daniel Schubert, CEO and Co-Founder of Revuud, this episode explores how AI is fundamentally reshaping healthcare IT strategy, from deploying countless virtual PhD-level agents across operations to rethinking patient access and workflow automation. Healthcare leaders discuss the challenge of prioritizing AI initiatives amid competing demands, the importance of creating organizational margin for creative problem-solving, and why divergent thinking beats linear logic in digital transformation. The conversation tackles talent deployment, the dangers of "we've always done it this way" mentality, and a critical question every CIO must answer: how resilient are your systems when AI becomes mission-critical infrastructure?Key Points:01:40 AI in Healthcare: A LinkedIn Post Discussion04:18 Challenges and Opportunities with AI08:38 Future of AI in Healthcare10:55 Organizational Impact and Talent Management20:05 Resilience and Final ThoughtsX: This Week HealthLinkedIn: This Week HealthDonate: Alex’s Lemonade Stand: Foundation for Childhood Cancer