UnHack with Drex DeFord

Drex explores a fundamental shift in AI: agents that don't wait for prompts, persist indefinitely, and now learn from each other through social platforms. Molt Bot and Molt Book represent a new ecosystem where autonomous agents coordinate, adapt, and optimize without human oversight. This isn't about sentient AI—it's about delegation without governance. For healthcare leaders, the urgent question isn't whether this matters, but whether you know which agents are already operating in your environment. The shift from "human in the loop" to "human on the loop" is already happening.
Remember, Stay a Little Paranoid
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February 2, 2026: Are health systems being sidelined from healthcare's innovation revolution? Jason Rose, CEO of Clearsense, joins This Week Health fresh from the J.P. Morgan Conference to challenge the narrative that providers are absent from innovation discussions. Jason reveals what really happened inside JPM's exclusive health system presentations, from CEOs prioritizing AI transformation to CFOs rising as the new power players driving technology strategy. The conversation explores why app rationalization remains the unglamorous financial lever that unlocks innovation budgets, and why simplification might be healthcare's most underrated competitive advantage in 2026.
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Key Points:
02:20 JPM Conference Insights
07:07 CEO and CFO Perspectives
13:54 Application Rationalization Challenges
22:40 Conclusion and Final Thoughts

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On Data Privacy Day, Drexon challenges healthcare leaders to move beyond compliance checkboxes and recognize privacy as a core component of "do no harm." As patient data flows through EHRs, cloud platforms, and AI systems, the responsibility to protect that trust doesn't live in policies—it lives with leadership. When data is over-collected or loosely governed, patients start holding back, and the critical trust between medical teams and patients begins to fracture. This year, data privacy should be about ownership: who decides what data we truly need, and who's willing to say no even when technology makes it easy?
Remember, Stay a Little Paranoid
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Donate: Alex’s Lemonade Stand: Foundation for Childhood Cancer

January 27, 2026: Jack Kufahl, CISO at Michigan Medicine, and Gregory Garneau, System VP and CISO at Hospital Sisters Health System, join Drex for an unfiltered conversation about building cybersecurity programs that outlast their founders. From hiring curious minds over credentialed experts to ditching traditional vulnerability management for threat-driven exposure strategies, these battle-tested CISOs reveal what actually works in healthcare security. They challenge conventional wisdom on staffing models, vendor relationships, and the real cost of forcing extraordinary people into ordinary roles. If you're tired of the same workforce shortage statistics and ready for actionable strategies, this conversation delivers.
Key Points:
05:09 Creating a World-Class Cybersecurity Team
19:50 Disruptive Startups in Cybersecurity
20:51 Importance of Vendor Partnerships
22:48 Training and Career Development
27:18 Leadership and Management Insights

Golf Tournament Registration: https://carahevents.carahsoft.com/Event/Details/686801-ThisWeekHealth
X: This Week Health
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Donate: Alex’s Lemonade Stand: Foundation for Childhood Cancer

January 26, 2026: Fresh from J.P. Morgan 2026, the This Week Health team joins Zahid Rathore, Senior Partner at Chartis, to dissect healthcare's new reality. With Epic and Microsoft topping CFO spend lists and unpredictability replacing planning cycles, one thing is clear: vendors must prove bankable ROI immediately or lose the deal. The conversation explores how healthcare leaders are protecting the core while navigating AI agents, third-party risks, and the compression of innovation timelines from three-year returns to prove-it-tomorrow expectations.
Key Points:
02:44 Hotel Experience and Healthcare Lessons
04:13 JP Morgan Conference Highlights
16:35 Operational Challenges in Healthcare
22:11 Security Concerns and Future Outlook