TBPN

(09:00) - Sam Altman discusses how increasingly capable AI agents can simplify work and daily life while fostering an open ecosystem for developers. He also addresses OpenAI’s startup culture, expanding computing infrastructure, simplified model selection, rapid experimentation, and the unresolved scientific challenge of aligning superintelligent AI.

(25:17) - Alexander Embiricos, an OpenAI product leader, discusses “dots,” proactive AI agents designed to act as personal delegates across workplace tools. He explains how personal and specialist dots can autonomously handle tasks, support individuals and enterprises, and make advanced AI more accessible through flexible interfaces and integrations.

(41:54) - Andrew Ambrosino discusses leading OpenAI’s Codex desktop and Space teams and unifying Codex’s agentic capabilities with ChatGPT. He highlights cloud and local-machine integration, collaborative AI workspaces, dynamic interfaces, faster models, and OpenAI’s iterative, feedback-driven product development.

(54:27) - Peter Steinberger discusses founding OpenClaw and pioneering personal AI agents that can proactively operate computers, use tools, and coordinate complex tasks. He explores agent-driven software development, changing online services, and a future where AI reshapes operating systems, commerce, and human workflows.

(01:16:22) - Tibo Sottiaux discusses his work leading AI agent development at OpenAI, including Dots, Codex, and advances in computer use. He explains how persistent agents can learn users’ preferences, securely perform specialized organizational tasks, share long-term memory, and automatically balance speed, cost, and reasoning effort.

(01:33:41) - Kath Korevec discusses her work as an OpenAI product manager for ChatGPT Sites, which reached 10 million sites within three months of launch. She highlights personal and professional uses, collaborative features within Spaces, new integrations and plugins, and plans to expand access to free users.

(01:41:50) - Casey Neistat discusses his perspective as a filmmaker, YouTube pioneer, and ModRetro executive on retro technology, AI-assisted creativity, and the value of simple, purpose-built devices. He argues that AI will democratize game and video creation while human taste, expertise, and curation remain essential amid a growing flood of content.

TBPN is made possible by:
Ramp - https://ramp.com
Public - https://public.com
Cisco - https://www.cisco.com
Console - https://www.console.com
CrowdStrike - https://www.crowdstrike.com
Figma - https://www.figma.com
MongoDB - https://www.mongodb.com
NYSE - https://www.nyse.com
Railway - https://railway.com
Shopify - https://www.shopify.com
Codex - http://openAI.com/codex

Follow TBPN: 
https://TBPN.com
https://x.com/tbpn
https://open.spotify.com/show/2L6WMqY3GUPCGBD0dX6p00?si=674252d53acf4231
https://podcasts.apple.com/us/podcast/tbpn/id1772360235
https://www.youtube.com/@TBPNLive

Diet TBPN delivers the best of today’s TBPN episode in 30 minutes. TBPN is a live tech talk show hosted by John Coogan and Jordi Hays, streaming weekdays 11–2 PT on X and YouTube, with each episode posted to podcast platforms right after.
Described by The New York Times as “Silicon Valley’s newest obsession,” the show has recently featured Mark Zuckerberg, Sam Altman, Mark Cuban, and Satya Nadella.
TBPN is made possible by:
Ramp - https://ramp.com
Public - https://public.com
Cisco - https://www.cisco.com
Console - https://www.console.com
CrowdStrike - https://www.crowdstrike.com
Figma - https://www.figma.com
MongoDB - https://www.mongodb.com
NYSE - https://www.nyse.com
Railway - https://railway.com
Shopify - https://www.shopify.com/
Follow TBPN: 
https://TBPN.com
https://x.com/tbpn
https://open.spotify.com/show/2L6WMqY3GUPCGBD0dX6p00?si=674252d53acf4231
https://podcasts.apple.com/us/podcast/technology-brothers/id1772360235
https://www.youtube.com/@TBPNLive

(00:46) - Dario Gets the SNL Treatment

(09:24) - Dario's Private Dinner with Trump

(12:15) - Cambridge Warns of AI Acceleration

(16:59) - Anthropic Investor Fears AI?

(21:57) - Inside Instinct's Rapid Rise/Some Personal Agent News

(47:06) - Zuck Hires MongoDB CEO

(58:32) - Lo Toney discusses his experience as the founding and managing partner of Plexo Capital, which he launched after serving as a partner at GV. He explains Plexo’s strategy of backing emerging venture fund managers, evaluating their technical expertise and investment perspectives, and using their networks to access promising companies, while also addressing AI’s impact, rapidly rising valuations, evolving fund strategies, and investments in controversial sectors.

(01:30:15) - Zack London discusses his work as Gossip Goblin, creating dark, sardonic AI-generated science-fiction videos and building a transhumanist universe. He explains how years of experimentation led him to launch a studio and produce a feature-length film with writers, voice actors, musicians, Foley artists, and a full post-production team, emphasizing that AI filmmaking still requires significant human craft and authorship.

(01:36:49) - Anish Acharya discusses how personal AI agents could benefit restaurants, streamline commerce, empower consumers, and eventually become independent economic actors. A general partner at Andreessen Horowitz, he also examines challenges involving advertising models, bot restrictions, legal disputes, and high computing costs.

(01:47:28) - Evan Conrad discusses San Francisco Compute’s mission to create independent, standardized compute markets that help new cloud providers build, finance, and sell GPU infrastructure. The co-founder and CEO explains how physically settled markets could reduce risk, improve utilization, and address potential AI infrastructure bubbles by establishing predictable future compute prices.

(02:00:49) - Gstaad Guy discusses his satirical characters, Constance and Colton, which embody the competing worlds of understated old-money taste and status-driven luxury. He explores how wealthy consumers develop discernment, why family-owned hospitality often preserves authentic luxury, and how he builds content for a small but influential audience rather than chasing mass appeal.

TBPN is made possible by:
Ramp - https://ramp.com
Public - https://public.com
Cisco - https://www.cisco.com
Console - https://www.console.com
CrowdStrike - https://www.crowdstrike.com
Figma - https://www.figma.com
MongoDB - https://www.mongodb.com
NYSE - https://www.nyse.com
Railway - https://railway.com
Shopify - https://www.shopify.com
Codex - http://openAI.com/codex

Follow TBPN: 
https://TBPN.com
https://x.com/tbpn
https://open.spotify.com/show/2L6WMqY3GUPCGBD0dX6p00?si=674252d53acf4231
https://podcasts.apple.com/us/podcast/tbpn/id1772360235
https://www.youtube.com/@TBPNLive

Diet TBPN delivers the best of today’s TBPN episode in 30 minutes. TBPN is a live tech talk show hosted by John Coogan and Jordi Hays, streaming weekdays 11–2 PT on X and YouTube, with each episode posted to podcast platforms right after.
Described by The New York Times as “Silicon Valley’s newest obsession,” the show has recently featured Mark Zuckerberg, Sam Altman, Mark Cuban, and Satya Nadella.
TBPN is made possible by:
Ramp - https://ramp.com
Public - https://public.com
Cisco - https://www.cisco.com
Console - https://www.console.com
CrowdStrike - https://www.crowdstrike.com
Figma - https://www.figma.com
MongoDB - https://www.mongodb.com
NYSE - https://www.nyse.com
Railway - https://railway.com
Shopify - https://www.shopify.com/
Follow TBPN: 
https://TBPN.com
https://x.com/tbpn
https://open.spotify.com/show/2L6WMqY3GUPCGBD0dX6p00?si=674252d53acf4231
https://podcasts.apple.com/us/podcast/technology-brothers/id1772360235
https://www.youtube.com/@TBPNLive

(00:54) - 4 Tech Arguments (Number 3 Will Shock You)

(24:09) - Has The AI Slop Gone Too Far?

(38:53) - Is AI Driving Interest Rates Higher?

(50:26) - WSJ Mansion Section

(56:00) - John Arnold discusses his career from natural gas trading at Enron to founding his own hedge fund and becoming co-founder and co-chair of Arnold Ventures. He shares insights on risk management, gambling-like financial products, AI infrastructure, energy markets, nuclear power, and the growing disconnect between private and public market valuations.

(01:44:12) - Viswa Colluru, founder and CEO of Invetta, discusses the company’s $311 million fundraising round and its AI-powered technology for identifying biological molecules and their functions. He outlines Invetta’s focus on developing medicines for widespread unmet needs—including asthma, eczema, and long-term weight management—and explains the practical limitations and safety considerations of AI-designed drugs.

(01:54:17) - Jake Adler discusses Pilgrim’s $25 million funding round and its mission to become America’s first biological prime contractor. He describes Argus, a portable “Shazam for the air” system designed to autonomously detect, identify, and characterize airborne biological threats in locations such as airports.

(02:02:22) - Adam Korsunsky discusses founding Freebean, an advertising company that distributes free, branded coffee as a tangible, targeted, and trackable marketing medium. He explains the company’s rapid growth, conference and campus distribution strategy, and launch of a New York City storefront billed as the world’s first free coffee shop.

TBPN is made possible by:
Ramp - https://ramp.com
Public - https://public.com
Cisco - https://www.cisco.com
Console - https://www.console.com
CrowdStrike - https://www.crowdstrike.com
Figma - https://www.figma.com
MongoDB - https://www.mongodb.com
NYSE - https://www.nyse.com
Railway - https://railway.com
Shopify - https://www.shopify.com
Codex - http://openAI.com/codex

Follow TBPN: 
https://TBPN.com
https://x.com/tbpn
https://open.spotify.com/show/2L6WMqY3GUPCGBD0dX6p00?si=674252d53acf4231
https://podcasts.apple.com/us/podcast/tbpn/id1772360235
https://www.youtube.com/@TBPNLive