TWiM explains how phages avoid tRNA-targeting host defenses, and discovery of a new antibiotic from an uncultured bacterium that binds to an immutable target. Hosts: Vincent Racaniello, Michael Schmidt, and Petra Levin, Become a patron of TWiM. Links for this episode Phages avoid tRNA-targeting host defenses (eLife) Sea phages Actinobacteriophage database New antibiotic from uncultured bacterium (bioRxiv) The age of infection (For Policy) Killing bacteria by teixobactin (Nature) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to [email protected]

TWiM reveals that the ice cream manufacturing environment harbors psychrotrophic bacteria, and identification of a deadly bacterial strain causing widespread deaths of newborns in Uganda. Hosts: Vincent Racaniello, Michael Schmidt, & Michele Swanson. Become a patron of TWiM. Links for this episode Pyschrotrophic bacteria in ice cream plants (Appl Environ Micro) Creamery pays fine for contaminated ice cream (US DOJ) Paenibacillus infection of infants in Uganda (The Lancet) Deadly bacterial strain identified (Yale SOM) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to [email protected]

TWiM explains personalized aerosilized phage therapy for a chronic lung infection, and using the combination of antibiotic and a DNA molecule that binds alpha-gal to reduce S. aureus infection in vivo. Hosts: Vincent Racaniello and Michael Schmidt Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Stitcher, Android, RSS, or by email. Become a Patron of TWiM! Links for this episode: Aerosolized phage therapy (Nat Comm) Alpha-gal aptamer and vancomycin for MRSA (Microorg) Alpha-gal syndrome (Front Allergy) Natural antibody protects against viral infection (virology blog) Oil pulling for improving oral health (Healthcare) Music used on TWiM is by Ronald Jenkees. Send your microbiology questions and comments to [email protected]

TWiM reveals that breast milk bioactives are essential for development of the infant microbiome and immunity, and how capsule mutants of Klebsiella pneumoniae can affect bacterial pathogenesis. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin, Become a patron of TWiM. Links for this episode Diet-microbe-host interaction in early life (Science) Human Milk: An Ideal Food (Front Ped) Determinants of Diabetes in the Young (Ann NY Acad Sci) Gut microbiome in early childhood (Nature) Probiotics Infloran and Labinic Cell envelope defects of Klebsiella pneumoniae (Mol Micro) A cautionary tale (Mol Micro) Global mortality associated with bacterial pathogens (Lancet) Take the TWiM Listener survey! Music used on TWiM is composed and performed by Ronald Jenkees Send your microbiology questions and comments (email or recorded audio) to [email protected]

TWiM explains how photoferrotrophic bacteria initiated plate tectonics over 2500 million years ago, and how two bacteria work together to cause childhood tooth decay. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin, Guest: Mark O. Martin Subscribe to TWiM (free) on Apple Podcasts, Spotify, Google Podcasts, Android, RSS, or by email. Become a patron of TWiM. Links for this episode Bacteria initiated plate tectonics (Geophys Res Lett) Medea hypothesis (Sci Am) Earth’s ferrous wheel (Nature) The Great Dying (Nova) The Great Oxidation Event (ASM) Banded iron formations (EarthSphere) S. sputigena and tooth decay (Nat Comm) Acid tolerance mechanisms of S. mutans (Fut. Micro.) Halitosis patients' tongue biofilm (Microbiol. Open) Take the TWiM Listener survey! Music used on TWiM is by Ronald Jenkees Send your microbiology questions and comments (email or recorded audio) to [email protected]