This Week in Virology

TWiV explains research showing how temperate phages enhance bacterial host fitness via RNA-guided flagellar remodelling, and that IgA antibody is necessary and sufficient to prevent norovirus infection in mice.
Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and Jolene Ramsey
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode
Support science education at MicrobeTV
Positions in Rosenfeld Lab (email)
Fred Murphy passes away (X)
US has lost its hold on measles elimination (CIDRAP)
What's in the genetic code of America's measles outbreaks (ProPublica)
Did Pete Hegseth single-handedly raise the R₀ of flu? (Inside Medicine)
Fred Murphy's Virus Images and Foundations of Virology (UTMB)
Temperate phages and RNA-guided flagellar remodelling (Nat Micro)
Eukaryotic RNA guided system (Nature)
IgA prevents norovirus infection in mice (Sci Transl Med)
Craig Wilen's letter to TWiV (TWiV 492)
Timestamps by Jolene Ramsey. Thanks!
Picks of the Week
Brianne – APod June 26: Milky Way Urban Style
Rich – Your birth order affects your future, but not for the reason you think; Dr. McCoy
Jolene – Bakteriopolis paper and site
Vincent – The Claude Shutdown Is a Total Sh*tshow
Listener Pick
Martin – Ancient text charred by Vesuvius read for first time in 2,000 years
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss the global economic burden of infectious disease, restoring trust in vaccinology, the Legionnaires outbreak in Harlem, new screwworm cases, the Ebola outbreak in the Congo and Uganda and an import case into France, end of the hantavirus outbreak before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, outbreak of measles in Cook County Illionis in 2025, loss of measles elimination in the US, how to access and pay for Paxlovid, publication of the blocked COVID-19 vaccine findings, where to go for answers about long COVID-19, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode
Health and economic burdens of emerging infectious diseases in the USA, US territories and globally (BMJ Journal of Global Health)
Meeting People Where They Are: Scientist-Creators Delivering Trusted Health Information on Social Media and Beyond (The Evidence Collective)
Vaccine Integrity Project, The Evidence Collective announce projects to improve vaccine policy, restore trust (CIDRAP)
Outbreak of Legionnaires' Disease Associated with Cooling Tower Systems in Central Harlem (NEJM Evidence)
Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service)
CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom)
Ebola dashboard (ebola.fyi)
 EBOLA:The Democratic Republic of the Congo, 2026 (WHO)
Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo)
Ebola Outbreak: Current Situation (CDC:Ebola)
France confirms first Ebola case (BBC)
Hantavirusdashboard (Hantavirus.up)
Hantavirus on board with Prof. VincentRacaniello (microbeTV)
Health agencies signal end of quarantine period for cruise-linked Andes virus outbreak (DG:Alerts)
HHS Successfully Concludes Hantavirus Response Effort; Monitoring Ends with No Positive U.S. Case (US: HHS)
Wastewater for measles (WasterWater Scan)
Measles cases and outbreaks (CDC Rubeola)
Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health)
Utah measles outbreak response (Utah Department of Health and Human Services)
UtahMeasles Dashboard (Utah Department of Health and Human Services)
US measles cases continue to climb, especially in Virginia (CIDRAP)
Measles (VDH: Virginia Department of Health)
Tracking Measles Cases in the U.S. (Johns Hopkins)
Measles vaccine recommendations from NYP (jpg)
Weekly measles and rubella monitoring (Government of Canada)
Measles (WHO)
Get the FACTS about measles (NY State Department of Health)
Measles(CDC Measles (Rubeola))
Measles vaccine (CDC Measles (Rubeola))
Presumptive evidence of measles immunity (CDC)
Contraindications and precautions to measles vaccination (CDC)
Measles (CDC Measles (Rubeola))
Measles (CDC: Measles Rubeola)
Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)
Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America)
Deaths following vaccination: what does the evidence show (Vaccine)
Measles Outbreak in Cook County, Illinois, September–October 2025 (NEJM Evidence)
CDC 'transitioning away' from diagnostic testing for measles, mumps (POLITICO PRO)
CIDRAP Op-Ed: Call it what it is—the US has lost its hold on measles elimination (CIDRAP)
Influenza: Waste water scan for 11 pathogens (WastewaterSCan)
USrespiratory virus activity (CDC Respiratory Illnesses)
Respiratory virus activity levels (CDC Respiratory Illnesses)
Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA)
WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP)
FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP)
Weekly surveillance report: clift notes (CDC FluView)
US military requires flu vaccine for some after outbreak in Texas training center (Reuters)
OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza)
RSV: Waste water scan for 11 pathogens (WastewaterSCan)
Respiratory Diseases (Yale School of Public Health)
USrespiratory virus activity (CDC Respiratory Illnesses)
RSV-Network (CDC Respiratory Syncytial virus Infection)
Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV))
Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP)
Respiratory Diseases (Yale School of Public Health)
Waste water scan for 11 pathogens (WastewaterSCan)
COVID-19 deaths (CDC)
Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses)
COVID-19 national and regional trends (CDC)
COVID-19 variant tracker (CDC)
SARS-CoV-2 genomes galore (Nextstrain)
CDC's chief blocked a covid vaccine study. Now it's in a top medical journal. (Washington Post)
Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design (JAMA Network: OPEN)
Where to get pemgarda (Pemgarda)
EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD)
Infusion center (Prime Fusions)
CDC Quarantine guidelines (CDC)
NIH COVID-19 treatment guidelines (NIH)
Drug interaction checker (University of Liverpool)
Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro)
Understanding Coverage Options (PAXCESS)
Infectious Disease Society guidelines for treatment and management (ID Society)
Molnupiravir safety and efficacy (JMV)
Convalescent plasma recommendation for immunocompromised (ID Society)
What to do when sick with a respiratory virus (CDC)
Managing healthcare staffing shortages (CDC)
Anticoagulationguidelines (hematology.org)
Daniel Griffin's evidence based medical practices for long COVID (OFID)
Long COVID hotline (Columbia : Columbia University Irving Medical Center)
The answers: Long COVID
Reaching out to US house representative
Letters read on TWiV 1334
Dr. Griffin's COVID treatment summary (pdf)
Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss the global economic burden of infectious disease, restoring trust in vaccinology, the Legionnaires outbreak in Harlem, new screwworm cases, the Ebola outbreak in the Congo and Uganda and an import case into France, end of the hantavirus outbreak before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, outbreak of measles in Cook County Illionis in 2025, loss of measles elimination in the US, how to access and pay for Paxlovid, publication of the blocked COVID-19 vaccine findings, where to go for answers about long COVID-19, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode
Health and economic burdens of emerging infectious diseases in the USA, US territories and globally (BMJ Journal of Global Health)
Meeting People Where They Are: Scientist-Creators Delivering Trusted Health Information on Social Media and Beyond (The Evidence Collective)
Vaccine Integrity Project, The Evidence Collective announce projects to improve vaccine policy, restore trust (CIDRAP)
Outbreak of Legionnaires' Disease Associated with Cooling Tower Systems in Central Harlem (NEJM Evidence)
Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service)
CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom)
Ebola dashboard (ebola.fyi)
 EBOLA:The Democratic Republic of the Congo, 2026 (WHO)
Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo)
Ebola Outbreak: Current Situation (CDC:Ebola)
France confirms first Ebola case (BBC)
Hantavirusdashboard (Hantavirus.up)
Hantavirus on board with Prof. VincentRacaniello (microbeTV)
Health agencies signal end of quarantine period for cruise-linked Andes virus outbreak (DG:Alerts)
HHS Successfully Concludes Hantavirus Response Effort; Monitoring Ends with No Positive U.S. Case (US: HHS)
Wastewater for measles (WasterWater Scan)
Measles cases and outbreaks (CDC Rubeola)
Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health)
Utah measles outbreak response (Utah Department of Health and Human Services)
UtahMeasles Dashboard (Utah Department of Health and Human Services)
US measles cases continue to climb, especially in Virginia (CIDRAP)
Measles (VDH: Virginia Department of Health)
Tracking Measles Cases in the U.S. (Johns Hopkins)
Measles vaccine recommendations from NYP (jpg)
Weekly measles and rubella monitoring (Government of Canada)
Measles (WHO)
Get the FACTS about measles (NY State Department of Health)
Measles(CDC Measles (Rubeola))
Measles vaccine (CDC Measles (Rubeola))
Presumptive evidence of measles immunity (CDC)
Contraindications and precautions to measles vaccination (CDC)
Measles (CDC Measles (Rubeola))
Measles (CDC: Measles Rubeola)
Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)
Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America)
Deaths following vaccination: what does the evidence show (Vaccine)
Measles Outbreak in Cook County, Illinois, September–October 2025 (NEJM Evidence)
CDC 'transitioning away' from diagnostic testing for measles, mumps (POLITICO PRO)
CIDRAP Op-Ed: Call it what it is—the US has lost its hold on measles elimination (CIDRAP)
Influenza: Waste water scan for 11 pathogens (WastewaterSCan)
USrespiratory virus activity (CDC Respiratory Illnesses)
Respiratory virus activity levels (CDC Respiratory Illnesses)
Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA)
WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP)
FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP)
Weekly surveillance report: clift notes (CDC FluView)
US military requires flu vaccine for some after outbreak in Texas training center (Reuters)
OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza)
RSV: Waste water scan for 11 pathogens (WastewaterSCan)
Respiratory Diseases (Yale School of Public Health)
USrespiratory virus activity (CDC Respiratory Illnesses)
RSV-Network (CDC Respiratory Syncytial virus Infection)
Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV))
Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP)
Respiratory Diseases (Yale School of Public Health)
Waste water scan for 11 pathogens (WastewaterSCan)
COVID-19 deaths (CDC)
Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses)
COVID-19 national and regional trends (CDC)
COVID-19 variant tracker (CDC)
SARS-CoV-2 genomes galore (Nextstrain)
CDC's chief blocked a covid vaccine study. Now it's in a top medical journal. (Washington Post)
Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design (JAMA Network: OPEN)
Where to get pemgarda (Pemgarda)
EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD)
Infusion center (Prime Fusions)
CDC Quarantine guidelines (CDC)
NIH COVID-19 treatment guidelines (NIH)
Drug interaction checker (University of Liverpool)
Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro)
Understanding Coverage Options (PAXCESS)
Infectious Disease Society guidelines for treatment and management (ID Society)
Molnupiravir safety and efficacy (JMV)
Convalescent plasma recommendation for immunocompromised (ID Society)
What to do when sick with a respiratory virus (CDC)
Managing healthcare staffing shortages (CDC)
Anticoagulationguidelines (hematology.org)
Daniel Griffin's evidence based medical practices for long COVID (OFID)
Long COVID hotline (Columbia : Columbia University Irving Medical Center)
The answers: Long COVID
Reaching out to US house representative
Letters read on TWiV 1334
Dr. Griffin's COVID treatment summary (pdf)
Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.

TWiV explains research showing how HIV-1 signalling remodels nuclear pores to licence infection, and development of STING agonist nanoparticles to enable coordinated mucosal-systemic immunity for durable pan-β-coronavirus protection.
Hosts: VVincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode
Support science education at MicrobeTV
Positions in Rosenfeld Lab (email)
Bundibugyo ebolavirus sitrep (WHO)
Ebolavirus and Andes virus with John Dye (TWiV Special)
Major research nonhuman primate supplier going out of business (Science)
HIV-1 signalling remodels nuclear pores to licence infection (Nature)
STING agonist nanoparticles enable mucosal-systemic immunity (Nature Nanoparticles)
Timestamps by Jolene Ramsey. Thanks!
Picks of the Week
Brianne – Otherworldly music albums feature space weather data
Rich – Evidence Mapping: Consolidating and summarising available evidence to support the demonstration of effectiveness of developmental vaccines, Australian Living Evidence Collaboration (ALEC)
Alan – Holyoke dam fish elevator
Vincent – 68 Quadrillion Underground Miles of Fungi
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.

Vincent travels to ASM Microbe in Washington DC to speak with John Dye of the United States Army Medical Research Institute of Infectious Diseases about the recent outbreaks of Bundibugyo ebolavirus in Africa and Andes virus on a cruise ship.
Host: Vincent Racaniello
Guest: John Dye
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.