Jack Altman sits down with Martin Casado, General Partner at a16z, to unpack the shifting dynamics of venture capital and why media matters more than ever. They cover a16z’s evolution from generalists to specialized platforms, the rise of AI infrastructure, and why today’s fiercest battles are often for talent, not market share.Timecodes:0:00 Introduction0:27 Importance of Media for VC3:50 Evolution of a16z7:00 Specialization10:32 Value of Distribution13:16 Staying Power in Infrastructure19:49 The Conflicts Dynamic26:32 State of Play in AI30:48 The Future of Coding34:58 Significance of Open Source39:48 Marc Andreessen’s Leadership44:02 The Only Sin in VC48:37 Scaling a Lot of Board SeatsResources: Listen to more from Uncapped: https://linktr.ee/uncappedpodFind Jack on X: https://x.com/jaltmaFind Uncapped on X: https://x.com/uncapped_podFind Martin on X: https://x.com/martin_casadoStay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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53:28
Chris Best of Substack on the Future of Media
What if the future of media isn’t controlled by algorithms or legacy institutions—but by independent voices building directly with their audiences?In this episode, Erik Torenberg is joined by Chris Best, cofounder and CEO of Substack, along with a16z general partners Katherine Boyle and Andrew Chen.We trace the origin story of Substack and its cultural impact, including how it reinvented the business model for independent media. We also explore the evolution of blogging, the rebundling of media, and what the future holds as attention becomes the scarcest resource.Timecodes: 00:00 Introduction03:50 Origins of Substack06:29 The Evolution of Blogging & Media Models09:15 Direct Audience Connection & Platform Independence10:57 Vision for Substack & The Role of Algorithms21:06 Business Models: Ads, Subscriptions, and AI26:10 The Scarcity of Attention & Value of Good Content27:45 Unbundling, Rebundling, and the Future of Media Companies37:12 Academia, Books, and Changing Content Formats44:31 Substack’s Next Phase & Closing ThoughtsResources: Find Chris on Substack: https://cb.substack.com/Find Chris on X: https://x.com/cjgbestFind Andrew Chen on Substack: https://andrewchen.substack.com/Find Andrew on X: https://x.com/andrewchenFind Katherine on X: https://x.com/KTmBoyleFind Katherine on Substack: https://boyle.substack.com/Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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46:23
Katherine Boyle on Shawn Ryan
Venture capital has powered companies like Facebook and TikTok—but what if that same urgency fueled America’s defense and industrial base? Katherine Boyle, General Partner at Andreessen Horowitz and cofounder of the firm’s American Dynamism practice, argues this is the biggest business opportunity of our time.In this conversation from The Shawn Ryan Show, Boyle discusses the rise of defense tech startups, why optimism drives her work, and how a new generation of engineers and founders is rethinking innovation and patriotism in America. Timecodes: 0:00 Introduction 0:41 Patriotism, Optimism, and American Innovation4:27 Startups vs. Legacy Primes in Defense10:08 Venture Capital’s Unique Incentives17:21 Katherine’s Backstory: Family & Upbringing21:07 The Decline of Community & Family Pillars23:23 Polarization, Religion, and Social Fabric26:16 America’s Birth Rate Crisis29:46 Cultural Shifts and the Family Structure42:01 Katherine’s Path: Journalism to Venture Capital1:06:06 Breaking into Silicon Valley1:18:06 Investing in Defense: The Anduril Story1:37:37 The American Dynamism Movement2:04:27 Manufacturing, Space, and the Future of Defense2:14:06 Espionage, China, and National Security2:37:38 The Attack on the American Family2:48:29 Cultural Change, Suffering, and Purpose2:55:30 Closing Thoughts Resources: Find Katherine on X: https://x.com/KTmBoyleShawn Ryan Show Links YouTube: https://www.youtube.com/channel/UCkoujZQZatbqy4KGcgjpVxQ/joinListen on Apple: https://podcasts.apple.com/us/podcast/shawn-ryan-show/id1492492083Listen on Spotify: https://open.spotify.com/show/5eodRZd3qR9VT1ip1wI7xQ?si=7abec4d61c324b24 Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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2:51:38
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2:51:38
Monopolies vs Oligopolies in AI
In this interview from the 20VC podcast, Martin Casado (a16z General Partner) joins Harry Stebbings to unpack the state of AI, the rise of coding models, the future of open vs. closed source, and how value is shifting across the stack.Martin offers a candid view of the opportunities and dangers shaping AI and venture capital today. Resources: Find Martin on X: https://x.com/martin_casadoFind Harry on X: https://x.com/harrystebbingsMore about 20VC:Subscribe on YouTube: https://www.youtube.com/@20VCSubscribe on Spotify:https://open.spotify.com/show/3j2KMcZTtgTNBKwtZBMHvl?si=85bc9196860e4466&nd=1&dlsi=d1dbbc6a0d7c4408Subscribe on Apple Podcasts:https://podcasts.apple.com/us/podcast/the-twenty-minute-vc-20vc-venture-capital-startup/id958230465Visit their Website: https://www.20vc.comSubscribe to their Newsletter: https://www.thetwentyminutevc.com/Follow 20VC on Instagram: https://www.instagram.com/20vchq/#Follow 20VC on TikTok: https://www.tiktok.com/@20vc_tok Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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1:17:25
The Top 100 Most Used AI Apps in 2025
What are real consumers actually doing with AI today?In this episode, a16z consumer investors Olivia Moore and Justine Moore break down the fifth edition of our Consumer AI 100, a biannual ranking of the most used AI-native web and mobile products across the globe. Timecodes: 0:00 Introduction1:45 New Companies & Trends3:32 Companionship & Creative Tools4:20 Big Tech on the List: Google’s Impact6:24 Chinese AI Companies & Global Trends10:19 Vibecoding: A New Trend13:40 AI All-Stars: Consistent Top Performers15:30 Network Effects & Product Experience17:20 Enterprise Adoption & Prosumer Growth19:40 Biggest Takeaways21:09 Grok's debut22:56 Future predictions25:14 Closing & Audience Engagement Resources:Read more about the Top Gen 100: http://a16z.com/100-gen-ai-apps-5/Find Olivia on X: https://x.com/omooretweetsFind Justine on X: https://x.com/venturetwins Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
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