49ers Talk: A San Francisco 49ers Podcast

One of the biggest matchups in the NFL in Week 5 sees two rivals suit up in a tug-of-war for divisional dominance. San Francisco embarks on the short trip to Seattle this weekend with more than bragging rights on their minds. "49ers Talk" host Matt Maiocco previews this epic matchup with Kyle Shanahan in his weekly sit-down with the coach. Shanahan breaks down how the 49ers prepared this offseason to counter a Seahawks team that seemed to have San Francisco's number late last season on their way to a Super Bowl win. Also, Matt reviews which 49ers players will be available in this crucial early-season barometer of strength and provides a much-anticipated update on Nick Bosa's return.
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(0:00) Another early-season test for the 49ers
(3:00) Update on Nick Bosa's return from injured calf
(6:00) The 49ers pass rush is still an area of concern
(8:00) The 49ers injury report
(15:00) Kyle Shanahan Game Plan interview ahead of Week 5

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San Francisco hasn't forgotten how last season ended in an NFC Divisional Playoff loss to the Seahawks at Lumen Field. On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan preview the 49ers' first crack at redemption against their NFC West rival in Week 5, and who will be available for the game as second-year defensive end Mykel Williams looks ready to make his season debut. Later, Matt talks with former NFL executive and agent Andrew Brandt about the business side of sports as they delve into the nitty-gritty of balancing professional contracts and salary caps.
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(0:00) NFC West matchup brings extra juice in Week 5
(5:00) 49ers playing numbers game with roster decisions
(8:00) When is Bosa coming back?
(10:00) Mykel Williams itching to return
(19:00) Purdy having an elite start to season
(40:00) Brandt breaks down how 49ers deal with Bosa’s massive contract next season

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San Francisco survived inhospitable heat and a bruising Broncos defense in its 24-14 win on Sunday at Levi's Stadium, improving to 4-0. The victory did come with collateral damage, with injuries to fullback Kyle Juszczyk, corner Upton Stout and safety Marques Sigle. The Broncos suffered significant injuries of their own in DBs Pat Surtain II and Riley Moss, while WR Pat Bryant was carted off the field with an ankle injury. On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan discuss how the 49ers battled through one of their toughest opponents yet while relying on the star-studded veteran core they've invested in for years. As their division arch-rival showdown with the Seattle Seahawks looms in Week 5, San Francisco has passed one of their biggest tests in Week 4.
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0:00) Early takeaways from Week 4 win vs. Broncos
(9:00) 49ers superstars showed up, showed out for win
(10:00) Why Deebo Samuel’s signing has been a revelation
(15:00) Brock Purdy ultimately had Purdy-type game
(20:00) Dre Greenlaw had point to prove vs. Broncos
(33:00) 49ers head to Seattle in Week 5

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The 49ers face arguably their biggest test of the 2026 NFL season thus far in Week 4 against the Denver Broncos as San Francisco seeks to remain undefeated. "49ers Talk" host Matt Maiocco previews this tough matchup with Kyle Shanahan in his weekly sit-down with the coach. They also break down the organization's strategy with drafting and developing O-linemen, and how they've found success reuniting with former players. Lastly, veteran right tackle Colton McKivitz joins Matt to discuss why the 49ers' O-line hasn't allowed a sack so far this season and the challenge of facing one of the NFL's most dominant defensive lines in Denver.

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(1:00) 49ers' sack record remains unblemished
(3:00) Where WR/D-line depth stands in Week 4
(10:00) Matt Maiocco sits down with Kyle Shanahan
(25:00) Colton McKivitz has turned into one of the top RT in the NFL
(26:00) Exclusive interview with McKivitz

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To offset a surge of early injuries this season, San Francisco has added veterans like Brandin Cooks, Dante Pettis and Matthew Judon. Their biggest addition so far, however, already is on the team, as defensive lineman Mykel Williams' 21-day practice window officially opened Wednesday while the 49ers evaluate his return from the PUP list. On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan discuss how the 49ers will manage their roster in the short-term as players arrive to provide depth and return from injuries. Later, the duo provides context to the offensive line's historical start and how the unit has enabled Brock Purdy to open the season without a single sack.

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(0:00) Reinforcements arrive at WR, DE to cover injuries
(6:00) WR Dante Pettis returns to 49ers on practice squad
(8:00) Mykel Williams' practice window officially opens
(10:00) What will the roles of the players on IR be once they come back
(13:00) How have the 49ers avoided a sack through three weeks

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