On the night of May 3rd, 2007, British 3-year-old Madeleine McCann went missing while on a family vacation to Portugal. That night, Madeleine’s parents Gerry and Kate McCann dined with friends at a nearby restaurant, leaving the toddler and her two younger siblings alone in the apartment at which they were staying. The adults took turns checking on the children throughout the evening, but as Kate returned to the complex, she discovered Madeleine was missing. Her disappearance sparked an international search effort, as well as a global media frenzy. 16 years later, the investigation continues with new developments in the case. FOX News London-based Senior Foreign Affairs Correspondent Greg Palkot joins with updates from the latest search operation in Portugal, as well as details about the current suspect in the case. Later, he discusses why Madeleine's disappearance continues to garner media attention all these years later. Follow Emily on Instagram: @realemilycompagno Learn more about your ad choices. Visit megaphone.fm/adchoices

Annie Le was a brilliant young woman destined for greatness. While enrolled in a pharmacology graduate program at Yale University, Annie was just days away from marrying her college sweetheart. However, on September 8, 2009, Annie vanished from the campus laboratory in which she regularly worked. Annie's disappearance sent shockwaves across the campus and tragically on September 13, 2009, the day she was to be wed, Annie's body was discovered. Retired New Haven Police Lieutenant Lisa Dadio discusses her involvement with the investigation, how it evolved from a missing person case to a murder case, and how their work led to the swift arrest of Raymond Clark III. Lisa Dadio spent 20 years with the New Haven Police Department, 16 of which were spent with the detective division. After ultimately rising to the rank of Lieutenant and commanding the Major Crimes Unit, Lisa retired from law enforcement and entered into the realm of higher education. She currently serves as the Assistant Dean for the Henry C. Lee College of Criminal Justice and Forensic Sciences at the University of New Haven. Follow Emily on Instagram: @realemilycompagno Learn more about your ad choices. Visit megaphone.fm/adchoices

Before he was known as the Golden State Killer, Joseph DeAngelo was known as the "East Area Rapist" by law enforcement. From 1976-1979, the Sacramento Sheriff's Department received various reports of home invasions and sexual assaults conducted by an unknown man. As a result of the serial attacks, a task force was soon formed in order to identify the attacker and bring an end to his horrific crimes.   As the sole female investigator on the case, retired Undersheriff in the Sacramento County Sheriff's Office, Carol Daly understood the importance of bringing empathy to those who suffered from the traumatic attacks. She discusses her role in the investigation of the "East Area Rapist," her close relationship with the victims, and her reaction to Joseph DeAngelo's arrest all these years later. Follow Emily on Instagram: @realemilycompagno Learn more about your ad choices. Visit megaphone.fm/adchoices

Throughout the 1970s and 80s, an unidentified man terrorized families across California. Responsible for more than 100 burglaries, over 50 rapes, and at least 13 homicides, the suspect was dubbed the "Golden State Killer." For decades, law enforcement worked tirelessly to uncover the identity of the murderer. In 2018, justice was served when former police officer Joseph DeAngelo was finally arrested at 74 years old. Retired FBI Agent and lead profiler on the Golden State Killer case Julia Cowley shares how she was brought onto the case, the work that went into creating Joseph DeAngelo's profile, and how her work played a pivotal role in the investigation. Julia Cowley served as a Forensic Scientist and Special Agent with the Tennessee Bureau of Investigation. Upon joining the FBI, Julia was assigned to the Boston Division where she investigated various violent crime cases and later rose to become the leader of their Evidence Response Team. In 2010, she was promoted to FBI Headquarters, where she worked in their Behavioral Analysis Unit. Follow Emily on Instagram: @realemilycompagno Learn more about your ad choices. Visit megaphone.fm/adchoices

In 2005, 18-year-old Natalee Holloway went missing while on a graduation trip to Aruba with her fellow classmates. According to her peers, Natalee was last seen leaving a club with Joran van der Sloot, a man who would soon become the prime suspect in her disappearance. While serving a 28-year prison sentence in Peru for the murder of 21-year-old Stephany Flores, van der Sloot is to be extradited to the United States where he faces charges of extortion and wire fraud. WBRC Anchor Jonathan Hardison has been covering the story from Birmingham, AL for years now. He discusses the timeline of events in the Natalee Holloway case, as well as the extradition and trial awaiting van der Sloot. Later, he shares the impact Natalee's disappearance has left on the community of Birmingham 18 years later. Follow Emily on Instagram: @realemilycompagno Learn more about your ad choices. Visit megaphone.fm/adchoices