59 episodes
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No one really prepares you for what perimenopause and menopause can actually feel like.
In this episode we get candid about their personal experiences with menopause from unexpected body changes, exhaustion and hot flashes to mood swings, sleep problems, changing sex drives and the impact it can have on relationships and marriage.
But the conversation doesn't stop there. We also discuss learning when to protect your private life, dealing with judgment on social media, faith and raising children with their own beliefs, and why wisdom sometimes means knowing what doesn't need to be shared with the internet.
00:00 What Menopause Really Feels Like
03:20 Perimenopause Symptoms We Weren’t Prepared For
05:57 How Menopause Affects Sex Drive and Libido
07:15 How Menopause Can Affect Marriage and Relationships
09:03 Menopause Mood Swings, Exhaustion and Sleep Problems
13:20 Our Experience With Hormone Replacement Therapy (HRT)
15:09 Estrogen, Progesterone and Testosterone During Menopause
17:10 Exercise, Weight Gain and Body Changes During Menopause
18:36 The Truth About Menopause Belly Fat
19:37 Why Sleep and Rest Matter More During Menopause
22:05 Motherhood and Getting Older
23:37 The Positive Side of Menopause No One Talks About
26:30 What We Wish We Knew Before Perimenopause
31:35 How Much of Your Life Should You Share Online?
33:59 Protecting Your Children’s Privacy on Social Media
35:17 Being Authentic Online Without Oversharing
39:00 Why You Shouldn’t Believe Everything You See Online
45:23 Finding Faith on Your Own Terms
48:06 AI, Social Media and Thinking Critically Online
53:41 Who Should We Interview Next?
If you are interested in advertising on this podcast email advertising@pionairepodcasting.com
To request Lise & Nicci to be on your Podcast, Radio Show, or TV Show, reach out to talent@pionairepodcasting.com
This podcast is for entertainment purposes only. Views expressed on this podcast solely reflect those of the host and do not reflect the views of Pionaire. - What is the real truth about women in sports? Olympic medalist Elana Meyers Taylor gets honest about the realities of being a female athlete in a male-dominated world.
But this episode goes far beyond the ice. Elana shares her deeply personal journey from being a Georgia softball player to becoming the most decorated Black athlete in Winter Olympics history. She also opens up about the raw, unrelenting reality of special needs motherhood, raising two deaf boys including her oldest son who has Down syndrome.
If you are interested in advertising on this podcast email advertising@pionairepodcasting.com
To request Lise & Nicci to be on your Podcast, Radio Show, or TV Show, reach out to talent@pionairepodcasting.com
This podcast is for entertainment purposes only. Views expressed on this podcast solely reflect those of the host and do not reflect the views of Pionaire. 57: Holly Simon GETS REAL about Breast Cancer, Raising a Son w/ Down Syndrome & DEFYING Expectations
09/03/2026 | 1h 2 mins.What happens when the world tells you to feel sorry for your child... and you decide to prove them wrong?
This week on Talk To Me Sis, we’re joined by Holly Simon, mom to social media sensation and 21 Pineapples founder Nate Simon. Holly and Nate have built a community of more than 1 million followers by doing something surprisingly simple: being completely, unapologetically themselves.
But their story started long before the followers, viral videos, and Hawaiian shirts.
When Nate was born with Down syndrome, Holly remembers doctors telling her they were “sorry.” His first year was filled with serious medical challenges, uncertainty, and moments when she didn’t know what the future would look like. Instead of accepting the limitations others placed on her son, Holly decided to change the conversation.
In this candid conversation, Holly opens up about motherhood, confidence, surviving life’s hardest chapters, learning to stop worrying about what other people think, and the power of owning your story.
Follow Holly and Nate:
TikTok: https://www.tiktok.com/@makenatethegreat
Instagram: https://www.instagram.com/natethegreatandmom/
21 Pineapples: https://21pineapples.com/
03:27 — Plot Twists of the Week
14:48 — Meet Holly Simon
16:15 — Who Was Holly Before Motherhood?
19:13 — “I’m Sorry” — The Words That Changed Everything
19:58 — When Doctors Almost Missed That Nate Was Dying
21:09 — The Fight to Keep Nate Alive
24:08 — “What the Hell Does Down Syndrome Mean?”
25:36 — The Moment Holly Became a Warrior
26:48 — Turning Pain Into a Mission
30:00 — Raising Nate: The Reality No One Prepared Her For
35:00 — From Motherhood to Finding Herself Again
40:00 — The Hardest Chapters Behind the Scenes
45:00 — Surviving Life’s Biggest Challenges
47:54 — Holly’s Secret to Confidence & Authenticity
48:47 — What Do You Want Your Legacy to Be?
50:24 — Who Nate Is Today
55:00 — The Power of Letting People Be Themselves
58:00 — What Holly Wants Every Mom to Know
If you are interested in advertising on this podcast email advertising@pionairepodcasting.com
To request Lise & Nicci to be on your Podcast, Radio Show, or TV Show, reach out to talent@pionairepodcasting.com
This podcast is for entertainment purposes only. Views expressed on this podcast solely reflect those of the host and do not reflect the views of Pionaire.- In this episode, we are joined by our sons from Netflix's Love on the Spectrum: Connor and Tanner! The guys share massive life updates, including the sweet story of how Connor met his new girlfriend, Sarah, and his upcoming trips to Hollywood for a brand-new history podcast. Tanner reveals the details behind his new kids' show, his adventures as an uncle, and his proven strategies for living independently.
We also have an honest conversation about life after reality TV, navigating brand deals, and how these incredible guys are kicking down doors for neurodivergent representation in the media.
00:00 - Connor on Finding Love After Heartbreak
04:09 - Tanner's Life Updates & Travels
05:47 - How Connor Met His Girlfriend, Sarah
09:08 - Tanner's New Kids' Show: Tanner Tries
11:14 - Connor's New History Podcast
12:36 - Best Advice for Handling Work Stress
20:29 - Tanner on Being an Uncle to Baby Chief
25:32 - Life After 'Love on the Spectrum'
30:26 - Tanner's Advice for Living Independently
33:47 - Brand Deals & Neurodivergent Creators - Caregiver burnout is a silent reality in the disability community, but the right support roadmap changes everything. Today, Cecilia Elizalde joins us to share how Best Buddies is providing vital resources not just for individuals with Intellectual and Developmental Disabilities (IDD), but for their entire family ecosystem.
From specialized mentorship for parents navigating a new Down syndrome or Autism diagnosis to app-based communities for siblings, this episode is packed with actionable advice.
00:00:00 - Why Caregiver Support is Critical in the Disability Community
00:02:09 - Navigating an Unexpected Down Syndrome Diagnosis
00:09:38 - The 5 Pillars of the Best Buddies Organization
00:12:11 - Eunice Buddies: Essential Advice for Newly Diagnosed Parents
00:22:04 - Inclusive Living: Independent Housing for Adults with IDD
00:33:10 - Support Groups for Siblings of Kids with Disabilities
00:38:54 - How to Find a Best Buddies Chapter in Your State
00:46:36 - The Family Forever Conference for Caregivers
00:48:05 - Revealing Next Week's Guests
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About Talk To Me Sis
Talk To Me Sis is a heartfelt and honest podcast hosted by two moms, Lise Smith and Nicci Smith, who first connected through the hit Netflix show Love on the Spectrum, but their bond goes far beyond reality TV.
United by their journeys of raising sons with autism (Connor Tomlinson and Tanner Smith), they dive into real conversations about motherhood, relationships, personal growth, and everything in between.
With humor, vulnerability, and unfiltered storytelling, Talk To Me Sis is a space where no topic is off-limits. Whether discussing love, parenting, or life’s unexpected turns, they invite listeners to laugh, cry, and connect, just like sisters do.
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