Open to Debate

Your doctor tells you that, should you wish to have a child, that child is likely also to carry the disease. But a new gene-editing technology could ensure that your baby is -- and remains -- healthy. Should you do it? Critics say the technology will exacerbate inequality and meddle in the most basic aspect of our humanity. Now, we debate: Should We Use Gene Editing to Make Better Babies? This ethical conundrum is at the crux of this week's debate, originally broadcast in February 2022.

Arguing Yes:

Dr. George Church, Geneticist & Founder, Personal Genome Project; Professor, Genetics, Wyss Institute and Harvard Medical School

Amy Webb, Chief Executive Officer, Future Today Strategy Group; Professor, NYU Stern School of Business 

Arguing No:

Marcy Darnovsky, Executive Director, Emerita, Center for Genetics and Society 

Françoise Baylis Distinguished Research Professor, Emerita, Dalhousie University; President, Royal Society of Canada 

Emmy award-winning journalist John Donvan moderates 

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Artificial intelligence has ignited one of the most spectacular surges of investment, hype, and technological promise, but some worry that the enthusiasm is resembling a bubble, with valuations racing ahead of fundamentals and enormous compute and energy costs that could undermine long-term profitability. But others note this bubble is different because AI is already embedded across the economy, not confined, and infrastructure is being created to sustain demand. Now we debate: Will the AI Bubble Burst? 

Arguing Yes: Ryan Cummings, Chief of Staff at the Stanford Institute for Economic Policy Research

Arguing No: Magnus Grimeland, Venture Capital Investor; Founder and CEO of Antler 

Emmy award-winning journalist John Donvan moderates 

Join the conversation on Substack - share your perspective on this episode and subscribe to our weekly newsletter for curated insights from our debaters, moderators, and staff. 

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Even with a fragile ceasefire in place between the U.S., Israel, and Iran, we wanted to revisit this prescient debate from last fall. In the past few weeks of war, autonomous systems, AI-driven targeting, and drones were heavily used by both sides leading some to fear we’re rapidly approaching a future of warfare that takes human decision making out of the loop entirely. Are we ready for that? This ethical conundrum is at the crux of this week's debate, originally broadcast in October 2025.

Arguing "Human": 

Elliot Ackerman, Former Marine Raider Officer and CIA Special Activities Officer; Bestselling Author 

Laura Walker McDonald, Senior Advisor for New Technologies & Conflict at the International Committee of the Red Cross  

Arguing "AI":  

Michael C. Horowitz, Senior Fellow for Technology and Innovation at the Council on Foreign Relations; Director of Perry World House and Richard Perry Professor at the University of Pennsylvania 

Jack Shanahan, Inaugural Director of Joint Artificial Intelligence Center, Office of the Department of Defense Chief Information Officer 

Emmy award-winning journalist John Donvan moderates 

Join the conversation on Substack—share your perspective on this episode and subscribe to our weekly newsletter for curated insights from our debaters, moderators, and staff. 

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At some point, we all ask: “Is this what I’m meant to do?” In this "Think Twice" episode, social scientist Arthur C. Brooks joins Open to Debate's CEO Lia Matthow to explore why meaning feels harder to find. Drawing on research from his book "The Meaning of Your Life: Finding Purpose in an Age of Emptiness," Brooks argues modern life pushes us toward shallow solutions that miss deeper human needs, and offers a path back to purpose, connection, and a life that truly feels lived. 

Our Guest: Arthur C. Brooks, New York Times Bestselling Author of "The Meaning of Your Life: Finding Purpose in an Age of Emptiness"; Professor at Harvard University; Columnist at The Free Press  

Lia Matthow, CEO of Open to Debate, is the guest moderator. 

Join the conversation on Substack - share your perspective on this episode and subscribe to our weekly newsletter for curated insights from our debaters, moderators, and staff. 

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NASA is preparing for the Artemis II mission — a major step back into deep space to explore the Moon. But as NASA, SpaceX, and other private companies are also working on plans to make Mars humanity’s next frontier, what comes next, and should Mars be the bigger priority? Those arguing “yes” say the U.S. should do it first before China, while opponents say major challenges make colonization unrealistic. Now we debate: Should the U.S. Prioritize Settling Mars?

Arguing Yes: Eric Berger, Senior Space Editor at Ars Technica 

Arguing No: Shannon Stirone, Freelance Science Writer 

Emmy award-winning journalist John Donvan moderates 

 Join the conversation on Substack - share your perspective on this episode and subscribe to our weekly newsletter for curated insights from our debaters, moderators, and staff. 

Follow us on YouTube, Instagram, LinkedIn, X, Facebook, and TikTok to stay connected with our mission and ongoing debates. 
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