The Neanderthal Mirror: Latest Findings About the Lines Between Us ~ David Gokhman
Genetics is rewriting the human story. This week, On Humans takes you behind the scenes of this rapidly evolving frontier via three live-recordings, captured at the Salk Institute's CARTA symposium on ancient DNA. The first episode explores the differences between us and the Neanderthals.For centuries, we tried to understand Neanderthals through stones and bones alone. Now genetics is offering a new tool, allowing researchers to see how ancient bodies and brains developed. In this opening episode, David Gokhman explains what these new tools are revealing about us, Neanderthals, and the lines between us.UP NEXT "Beyond Race: New Surprises About the Shape of Humanity" ~ Monday Dec 1st with Diyendo Massilani"Restless Humanity: The Epic Migrations Into America, Polynesia, and... Beyond?" ~ Thursday Dec 4th with Andrés Moreno-EstradaFACT CHECKINGNo major errors have been found yet. If you find an error in this or other episodes, get in touch via the form below.LINKSArticles and essays: OnHumans.Substack.comSupport: Patreon.com/OnHumansContact Form: https://forms.gle/h5wcmefuwvD6asos8CARTA symposiumGokhman's labKEYWORDSHuman evolution | Human origins | Anthropogeny | Anthropology | Paleoanthropology | Genus Homo | Neanderthals | Ancient DNA | Comparative genetics | Archaeogenetics | Language evolution | Origins of language | Symbolic culture | Extinction | Species concept
--------
21:35
--------
21:35
Can We Tell a (True) Story of Human Origins? Live from UC San Diego
The science of human origins keeps producing new theories. But are we any closer to telling a true story of human origins? Or are we simply drowning in data? Earlier this November, the chair of UCSD’s Department of Anthropology invited me to explore this question in a campus talk. My optimistic claim was that underneath many of the field’s important debates, a powerful story has been emerging. At its core, this is a story about calories, cooperation, and climate change. And at the centre of it are not men hunting or women gathering.At the centre of it are children playing and learning.Here is the recording from the talk . Check out also my Substack essay inspired by this talk, with many of the pictures and graphs from the slides! PS. I was in San Diego to attend a CARTA symposium on the role of genetics in the study of human origins. I managed to record three episodes behind the scenes. Live recordings coming soon!FACT CHECKINGNo major errors have been found yet. As a small correction, the mention about macaques vs giraffe's should have been about neurons in the cortex, not total neurons in the brain. The main idea doesn't change. If you find an error in this or other episodes, get in touch via the form below.LINKSArticles and essays: OnHumans.Substack.comSupport: Patreon.com/OnHumansContact Form: https://forms.gle/h5wcmefuwvD6asos8KEYWORDSHuman evolution | Human origins | Anthropogeny | Anthropology | Paleoanthropology | Genus Homo | Australopithecins | Human brain | Comparative neuroanatomy | Human tool cultures | Alloparenting | Cooking hypothesis | Expensive tissue hypothesis | Life history | r vs K strategies |
--------
42:21
--------
42:21
Epilogue: Is the Brain Free to Choose? ~ Tim Coulson
You decided to start reading this. But could you have chosen otherwise? In this short epilogue to this fall's brain science -series, Oxford biologist Tim Coulson gives his defense of free will. (The episode is an unheard clip from the conversation with Tim Coulson, originally recorded as part of the Origins of Humankind -series in March 2025. )LINKS For highlights, longer quotes, and references, see my essay at OnHumans.Substack.com.Tim Coulson's book is called The Universal History of Us (in the UK) and The Science of Why We Exist (in the US). For more episodes on the human brain, check OnHumans.Substack.com/BrainWant to support the show? Join the club at Patreon.com/OnHumansMENTIONSNames: Albert Einstein | Niels Bohr Terms and concepts: free will | many worlds -interpretation vs the Copenhaguen interpretation of quantum mechanics | Brownian motion | Quantum biology | stochasticity vs determinism | neural integration vs complexity | chance & necessity | philosophy | physics | biology | neuroscience
--------
16:24
--------
16:24
Can the Brain Understand Itself? The Glories and the Limits of Neuroscience ~ Matthew Cobb
Science has learned much about the brain. But how well do we understand this organ of the mind? Are we even close to cracking the neural code? Is a groundbreaking theory of consciousness just around the corner?In this final episode of the brain science -series, Matthew Cobb takes us on a tour of the story of neuroscience. We meet many colourful characters, but this is not just a history for history’s sake. More importantly, this is a reflection on the increasingly clear limits that brain science is coming up against — limits often left invisible behind the thirst for stories about new discoveries. Enjoy!FACT CHECKINGContrary to the precise phrasing in the episode, a handful of new psychiatric drugs have entered the market recently. The general observation remains well-supported.If you spot an error in this or other episodes, please reach out on Substack or via email.LINKSMatthew Cobb’s book is The Idea of the Brain: The Past and Future of Neuroscience For more episodes on the human brain, check OnHumans.Substack.com/BrainWant to support the show? Join the club at Patreon.com/OnHumansMENTIONSNames: Matthew Cobb | Galen | Aristotle | Andreas Vesalius | William Harvey | William Shakespeare | Queen Victoria | Karl Marx | Pierre Paul Broca | René Descartes | Eve Marder | David Marr | Francis Crick | Geoffrey Hinton | John Hopfield | Warren McCulloch | Walter Pitts | John von Neumann | Alan Turing | Kenneth Craik | Sir John Eccles | Elon Musk | Nicolaus Copernicus | Galileo Galilei Terms and concepts: recurrent laryngeal nerve | phrenology | localization of function | strokes/aphasia | Broca’s area | plasticity | hemispheric lateralization | corpus callosum | split-brain | consciousness | anesthesia (halothane, etc.) | drugs & neuromodulators | SSRIs | serotonin | dopamine | psychedelics | obster stomatogastric ganglion | three-body-problem | EEG “brainwaves” (gamma, theta, etc.) | David Marr’s levels | neural code | PDP / connectionism | backpropagation | LLMs (e.g. ChatGPT, DeepSeek) | biological plausibility vs engineering | von Neumann architecture | McCulloch–Pitts logical neurons | neural correlates of consciousness (NCC) | “Jennifer Aniston” cells | single-unit recording | connectomics | Human Brain Project | cochlear implants | BCI / robotic arm control | tetraplegia | problem of consciousness | enactive cognition
--------
1:00:14
--------
1:00:14
From Alcohol to Antidepressants: What Drugs Teach Us About Brain Chemistry ~ Judy Grisel
Dopamine. Serotonin. Endorphins. We have all heard these terms. And these are not just scientific curiosities. Few are those who have never wondered if their brain chemicals are "just off balance". So how accurate are the popular theories about these mythic molecules? To guide us through the topic, I'm joined by Judy Grisel—an ex-addict and a world-leading neuroscientist of addiction. We will discuss all the main elements of brain chemistry by using drugs and addictions as a window into the topic. Towards the end, we also search for ways to better help those who struggle with addiction. As always, we finish with my guest's reflection on humanity.DIG DEEPERThis episode is part 4 of this autumn's brain science series. See more at OnHumans.Substack.com/brainJudy Grisel’s book is Never Enough: The Neuroscience and Experience of Addiction Want to support the show? Join the club at Patreon.com/OnHumans.FACT-CHECKINGNo major mistakes have been found so far.As a minor note, the SSRI study we mention in healthy volunteers primarily assessed cognitive processing (reinforcement learning/sensitivity) rather than self-reported “emotional flattening”; however, general blunting of emotional responses in healthy participants has been reported by earlier researchers.If you spot an error in this or other episodes, please reach out on Substack or via email.KEYWORDSNames mentioned: Kent Berridge | Mark Lewis | Barbara Sahakian | Trevor RobbinsTechnical concepts: dopamine | wanting vs liking | serotonin (5/HT) | serotonin receptor 2A | selective serotonin uptake inhibitors SSRIs | GABA vs glutamate | endorphins | endocannabinoids | alcohol | cocaine | MDMA | psychedelics | behavioral addictions (e.g. porn) | runner's high | cannabis / THC | neurogenesis & pruning | brain plasticity | SSRIs | MDMA (SERT reversal) | emotional blunting | opponent-process theory (A→B) | addiction as disease vs learned state | meaning, motivation, recovery
Where do we come from? How did we get here? And what kinds of creatures are we?
On Humans features conversations with leading scholars about human nature, human condition, and the human journey. From the origins of war to the biology of love, each episode brings fresh insights into perennial questions about our self-understanding.
The show now unfolds in series of episodes built around a chosen theme, offering ever-deeper dives into some of the biggest questions in science, philosophy, and history.
Welcome to the journey!
USA