The Optispan Podcast with Matt Kaeberlein

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/As we close out 2025, I'm sharing a comprehensive and honest review of my personal health optimization protocol. I break down the exact lifestyle habits, supplements, and medications I use daily, and just as importantly, which popular ones I avoid and why.I detail the massive impact of my "Four Pillars" and explain the thought process behind each item in my regimen, from Omega-3s and creatine to testosterone, SGLT2 inhibitors, and rapamycin.If you've ever wondered what a data-driven, no-BS approach to longevity looks like in practice, this is it.*Timestamps:*00:00 - Podcast Start / Topic Overview01:16 - Philosophy: Focus on Foundations, Not Hype02:10 - The Four Pillars of Healthspan (Eat, Move, Sleep, Connect)03:27 - My Personal Pillars Assessment04:33 - Avoiding Risky Behaviors (Alcohol, Drugs, Environment)06:44 - Pillar 1: EAT - My Rules, Keto Bread, Protein Sources09:51 - Pillar 2: MOVE - Weekly Exercise Routine (Zone 2, Weights, HIIT)12:19 - Pillar 3: SLEEP - Routine & The Alcohol Effect13:29 - Pillar 4: CONNECT - Relationships & Personal Growth14:52 - SUPPLEMENTS: My Skeptical Philosophy16:43 - Supplement Disclosures (Past/Present Company Ties)17:47 - My Daily Supplements List: Omega-3, Vitamin D, Rejuvent (CA-AKG), Lithium, Methylfolate, Creatine23:03 - Supplements I DON'T Take: Magnesium, Collagen, Fiber, Ashwagandha, NAD+ Boosters, Senolytics & Why28:42 - How to Choose a Supplement Brand (ConsumerLab Warning)30:19 - MEDICATIONS & PREVENTATIVE DRUGS30:48 - Testosterone Therapy: My Protocol, Impact, & Monitoring33:49 - Jardiance (Empagliflozin): SGLT2 Inhibitor for Biomarkers35:55 - Repatha (PCSK9 Inhibitor): For Heart Disease Prevention37:47 - Tirzepatide (Mounjaro/Zepbound): My Microdosing Experience40:01 - Rapamycin (Sirolimus): My Cyclical Protocol & Stance on Recent News41:41 - Tadalafil (Cialis) & Metformin: Why I'm Off/Against Them For Now46:08 - Final Summary & Take-Home Principles46:50 - The Importance of a Good Doctor & Rational Risk/Reward48:48 - Wrap-Up & Holiday WishesThis video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispan

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/They call it the "whorebath" test. 🛁 We call it a massive misunderstanding of science.ing biological age tests.In this episode, Dr. Matt cuts through the noise to explain what ageing clocks actually are, what they measure, and more importantly, what they DON'T. You'll learn why that $500 direct-to-consumer test is likely giving you meaningless noise, why seeing a drop in your "biological age" is often a statistical illusion, and what to do if your doctor recommends one.By the end, you'll understand ageing clocks better than 95% of the supposed experts and influencers out there. You'll also learn about the type of clock that shows real promise for personalized health today.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Timestamps0:00 - Introduction1:18 - What Inspired This Deep Dive1:54 - My Actual Position on Ageing Clocks7:49 - Take Home #1: What is a Clock, Really?10:30 - How Biomarkers (Like VO2 Max) Correlate to Age15:32 - The Problem: My "Age" is 40 AND 6925:22 - Take Home #2: The Many Flavors of Clocks36:53 - Take Home #3: Clocks Do NOT Measure Ageing38:15 - Take Home #4: Clocks ARE Useful... For Research39:52 - Take Home #5: Why They're Useless Outside Research42:05 - Precision vs. Accuracy: The Fatal Flaw48:38 - A Statistical Nightmare: Your Quarterly Test Results53:50 - BONUS: The Clocks That Might Actually Work (PhenoAge, ENABLE Age, LinAge₂)1:01:06 - The 5 Take-Home Messages Summarized1:02:03 - Final Advice & A Question for DoctorsDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Join Matt and Dr. Nicole (Nicki) Byrne, Clinic Director at Optispan, for a deep dive into preventative Healthspan Medicine. In this episode, they discuss why traditional reactive healthcare is failing us, what true preventative care looks like, and the comprehensive, data-driven approach used at Optispan to catch risks early and optimize long-term health. From advanced diagnostics to lifestyle pillars and evidence-based medications, learn how to shift from treating disease to building resilience.🔬 Topics Covered:The moment Dr. Byrne realized traditional medicine was focused on the wrong end of the problem.The dangers and gaps in the current "longevity medicine" ecosystem.A complete walkthrough of Optispan's Gateway Day assessment: advanced bloodwork, genetics, point-of-care ultrasound, DEXA scans, CGM, sleep tracking, and more.Real patient examples of conditions caught early that standard care would have missed (e.g., insulin resistance, fatty liver, plaque buildup).How data from multiple sources creates a personalized health blueprint.The philosophy behind using medications (like GLP-1s, SGLT2 inhibitors, Rapamycin) and supplements preventatively.The critical pillars of health: Eat, Move, Sleep, and Connect.A vision for how healthcare should work in the next five years.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Timestamps1:04 Meet Dr. Nicki Byrne3:25 The 80-Year-Old With "Hormones of a 25-Year-Old"4:41 "People Think I'm a Snake Oil Salesman"9:52 She Looked Healthy—Then We Found Plaque13:56 The Danger of a "Negative" Cancer Screening17:00 Why Your "Normal" Lab Results Might Not Be Normal for You25:44 What Actually Happens During a 5-Hour Health Day33:29 What Your 3am Blood Sugar Spike Is Really Telling You35:09 You're Probably Lying to Yourself About Sleep38:24 Insulin Resistance: The Root of All Evil43:07 Wealthy, Successful… and Lonely51:08 Peptides From a Sketchy Website? Here's What to Know1:06:20 The Rapamycin Skin Cream Experiment1:08:05 What Should Be "Normal" Healthcare in 5 YearsDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

This is an AMA episode where Dr Matt answers the pressing questions audience had. In this episode, Matt shares candid updates on his TRT journey and physique, debates rapamycin protocols vs. extreme fasting, and separates the scary headlines from the science on microplastics and "magic" mushrooms. Plus: why he wakes up at 4:30 AM, the truth about HBOT, and a surprising update on his books.Timestamps0:00 Intro1:00 Is Matt Still Taking Rapamycin?6:09 Best Time of Day to Take Rapamycin8:29 48-Hour Fasting vs. Rapamycin for Longevity11:44 Why Matt Wakes Up at 4:30 AM14:43 Supplement Updates: Creatine, Astaxanthin & Glycine19:27 Hyperbaric Oxygen Therapy for Brain Health26:04 Epigenetic Clocks vs. Functional Biomarkers30:54 Microplastics: How Worried Should You Be?37:55 Matt's TRT Results After 6 Months43:00 TRT Side Effects: Hair Loss, Blood Work & HDL ChangesThis video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

This podcast episode is part three of a travel series where Matt recounts his recent trips to longevity and healthspan conferences in Geneva, Chicago, and Mauritius. He shares his experiences with jet lag, workouts, and the contrasting cultures of these events, from the more "alternative medicine" feel of the Geneva summit to the more scientifically-grounded Mauritius conference. A major theme is his critique of the current state of the longevity field, where he advocates for evidence-based approaches and calls out what he sees as misinformation, specifically regarding the overhyping of peptides, stem cells, and the misuse of epigenetic "aging clocks."This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/